Complete genome sequence of strain FW102 with β-galactosidase activity in drinking fountain water.

is a ubiquitous environmental microbe in nature, particularly abundant in soil and water sources. Recently, has been considered to be a potential opportunistic pathogen in humans. We report the 5,9540,064-bp genome sequence of strain FW102 isolated from drinking fountain water and predicted to have multiple copies of β-galactosidase genes.

Complete genome sequences of CP201 isolated from an asymptomatic rhesus monkey ().

is a leading cause of human gastroenteritis. The genome sequence of CP201 from an asymptomatic rhesus monkey, , consists of one chromosome (3,241,413 bp; 30.22% G + C) and one plasmid (92,983 bp; 28.

Complete genome sequence of strain NCTR 501 isolated from the inner ear of a laboratory mouse () diagnosed with otitis media.

We report the circularized 6,427,509-bp genome of isolated from the inner ear of a laboratory mouse () diagnosed with otitis media. The genome of NCTR 501 has a circular chromosome of 6,420,288 bp and two plasmids of 4,042 and 3,179 bp, respectively.

Differences in Connected Speech Outcomes Across Elicitation Methods.

Background: Connected speech is often used to assess many aspects of an individual's language abilities after stroke. However, it is unknown the degree to which elicitation methods differ in generating structural and syntactic aspects of connected speech, two critical components of successful communication. Quantifying the degree to which elicitation methods differ in eliciting structurally, syntactically, and lexically complex connected speech at the earliest stage of stroke before reorganization and rehabilitation of function independent of clinical diagnosis of aphasia has not been examined to date.

Complete genome sequences of subsp. strain P4549 isolated from an asymptomatic rhesus monkey ().

subsp. is a leading bacterial cause of human gastroenteritis. strain P4549 was isolated from an asymptomatic rhesus monkey, .

Complete genome sequence of two chromosomes of strain ZF102 isolated from the abdominal cavity of moribund laboratory zebrafish ().

was isolated from the abdominal cavity of moribund laboratory zebrafish. We report complete genomic sequences of strain ZF102 that has two circular chromosomes of 2,872,299 and 1,170,691 bp and two plasmids of 5,265 and 2,361 bp.

Complete genome sequence of strain HA60 isolated from a commercial hydroxyapatite nano-particle product (nano-hydroxyapatite).

a Gram-negative rod-shaped aerobic bacterium with environmental remediation functions. strain HA60 was isolated from a commercial nano-particle product, nano-hydroxyapatite. We report that the genome of strain HA60 has a circular genome of 6,922,195 base pairs with a G+C content of 66.

Anosognosia is associated with increased prevalence and faster development of neuropsychiatric symptoms in mild cognitive impairment.

Introduction: Both the loss of awareness for cognitive decline (a. k.a anosognosia) and neuropsychiatric symptoms (NPS) are common in patients with Alzheimer's disease (AD) dementia, even in prodromal stages, and may exacerbate functional impairment and negatively impact caregiver burden.

Complete genome sequence of strain GP102, isolated from the cecum of a morbid pregnant laboratory guinea pig ().

is an anaerobic bacterium with ambivalent health effects. strain GP102 was isolated from the cecum content of a morbid pregnant laboratory guinea pig (). The genome consists of one circular 5.

Genome sequence of strain WW102, isolated from influent wastewater at a research center with multiple-species research animal facilities.

is a little known mesophilic Gram-positive rod-shaped bacterium. We report the 3.85-Mbp genome sequence of strain WW102, isolated from wastewater at a research center with multiple-species laboratory animal facilities.

Complete Genome Sequence of Invasive MLST-Untypeable Serotype 3 -Deficient Streptococcus pneumoniae Strain B1900, Isolated from the Brain of an Infant Rhesus Monkey (Macaca mulatta) That Died of Meningitis.

Serotype 3 Streptococcus pneumoniae is associated with major invasive pneumococcal diseases in humans. We report the circularized 2.0-Mbp complete genome sequence of invasive serotype 3 S.

Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings.

Background: Detecting clinically meaningful changes in instrumental activities of daily living (IADL) at the earliest stages of Alzheimer's disease (AD) is critical.

Objective: The objective of this exploratory study was to examine the cross-sectional relationship between a performance-based IADL test, the Harvard Automated Phone Task (APT), and cerebral tau and amyloid burden in cognitively normal (CN) older adults.

Methods: Seventy-seven CN participants underwent flortaucipir tau and Pittsburgh Compound B amyloid PET.

A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories.

The majority of children with maltreatment histories do not go on to develop depression in their adolescent and adult years. These individuals are often identified as being "resilient", but this characterization may conceal difficulties that individuals with maltreatment histories might face in their interpersonal relationships, substance use, physical health, and/or socioeconomic outcomes in their later lives. This study examined how adolescents with maltreatment histories who exhibit low levels of depression function in other domains during their adult years.

Valley fever, mimicker of malignancy.

Coccidioidomycosis rates in endemic areas such as California and Arizona have been increasing in recent years. Most common manifestations in symptomatic individuals involve the lungs. Disseminated disease occurs when the infection spreads beyond the lungs.

Double-stranded RNA reduction by chaotropic agents during transcription of messenger RNA.

-transcribed messenger RNA (mRNA) has recently shown increasing significance in the development of vaccines and therapeutics. Immunogenic double-stranded RNA (dsRNA) is an undesired byproduct formed during transcription (IVT), and it is challenging to reduce dsRNA byproduct from mRNA due to their similar sizes and intrinsic characteristics. Removal of dsRNA relies heavily on post-IVT chromatography purifications, such as reverse-phase high-pressure liquid chromatography, which increase manufacturing costs, reduce yield, and often decrease integrity, especially for long mRNA.

Legionnaire's Disease Presenting With the Legionella Triad (Pneumonia, Rhabdomyolysis, and Renal Failure) and Cardiac Complications.

pneumonia is well-characterized as a cause of atypical, community-acquired pneumonia in susceptible individuals. In recent years, extrapulmonary manifestations, including an emerging triad of pneumonia, rhabdomyolysis, and renal failure, have been identified. Here we report a case of Legionnaire's disease that presented non-classically, with subclinical pneumonia and non-ST elevated myocardial infarction (NSTEMI).

Prevalence of Central Line-Associated Bloodstream Infections (CLABSI) in Intensive Care and Medical-Surgical Units.

Background:  Central line-associated bloodstream infections (CLABSIs) remain an important preventable healthcare-associated infection with a 2020 rate of 0.87 (per 1,000 central line days) in the United States intensive care units (ICU).

Methods:  This was a retrospective cohort study of all adult patients in our institution.

Racial and socioeconomic status differences in stress, posttraumatic growth, and mental health in an older adult cohort during the COVID-19 pandemic.

Background: The COVID-19 pandemic has disproportionately impacted the most vulnerable and widened the health disparity gap in both physical and mental well-being. Consequentially, it is vital to understand how to best support elderly individuals, particularly Black Americans and people of low socioeconomic status, in navigating stressful situations during the COVID-19 pandemic and beyond. The aim of this study was to investigate perceived levels of stress, posttraumatic growth, coping strategies, socioeconomic status, and mental health between Black and non-Hispanic, White older adults, the majority over the age of 70.

Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity.

Infiltration of regulatory T cells (Tregs) in the tumor microenvironment suppresses anti-tumor immune response, and promotes tumor progression. Tumor necrosis factor receptor-2 (TNFR2), which is highly expressed on Tregs, activates Tregs through nuclear factor kappa B (NF-κB) pathway. Moreover, TNFR2 Tregs have been shown to be most suppressive among all Tregs populations in tumor.

Tracheobronchitis Due to Invasive Aspergillus fumigatus in a Male With HIV With Minimal Imaging Findings.

tracheobronchitis (AT) is a rare manifestation of invasive aspergillosis. We present a case of tracheobronchitis caused by in a 33-year-old male with neutropenia and known human immunodeficiency virus (HIV) infection with acquired immunodeficiency syndrome (AIDS). A 33-year-old male with HIV/AIDS presented to the hospital with symptoms of productive cough for over two months associated with subjective fevers, chills, and body aches.

Emergent Inpatient Administration of Casirivimab and Imdevimab Antibody Cocktail for the Treatment of COVID-19 Pneumonia.

Infection by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is known to have the highest mortality rate among the elderly and those with pre-existing medical conditions. Viral load has been directly correlated with increased risk of mortality in hospitalized patients. Once infected, symptoms first arise approximately six to seven days later followed by immunoglobulin M (IgM) antibodies appearing 8-12 days after onset of clinical symptoms.