Publications by authors named "Sharon Senchanthisai"
Article Synopsis
- T2 cells and innate lymphoid cells 2 (ILC2) can promote tumor growth by producing cytokines like IL-4, IL-5, and IL-13, but how these immune cells reach tumors is unclear.
- This study reveals that oncogenic Kras enhances IL-33 levels in pancreatic ductal adenocarcinoma (PDAC) cells, which helps recruit and activate T2 and ILC2 cells, with deletion of IL-33 leading to reduced recruitment and tumor slowdown.
- Interestingly, IL-33 secretion relies on the presence of intratumoral fungi, and blocking IL-33 or treating with anti-fungal methods can reduce T2 and ILC2 cell infiltration, potentially improving survival rates in
Oxidative stress and inflammation play key roles in development of pulmonary arterial hypertension (PAH). We previously reported that an endothelial cell (EC)-specific cyclophilin A overexpression mouse developed many characteristics of PAH. In other models of cardiovascular disease, cyclophilin A stimulates smooth muscle proliferation and vascular inflammation, but mechanisms responsible for PAH have not been defined.
View Article and Find Full Text PDFThe spatiotemporal localization and expression of Dll4 are critical for sprouting angiogenesis. However, the related mechanisms are poorly understood. Here, we show that G-protein-coupled receptor-kinase interacting protein-1 (GIT1) is a robust endogenous inhibitor of Dll4-Notch1 signaling that specifically controls stalk cell fate.
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