Publications by authors named "Sharon S M Ng"
Safety, efficacy and immunogenicity of aerosolized Ad5-nCoV COVID-19 vaccine in a non-inferiority randomized controlled trial.
NPJ Vaccines
October 2024
Article Synopsis
- - This clinical trial compared the safety and effectiveness of an inhaled COVID-19 vaccine (Ad5-nCoV-IH) against an intramuscular vaccine (BNT-IM) in 540 vaccinated adults in Malaysia from September 2022 to May 2023.
- - While Ad5-nCoV-IH exhibited lower immunogenicity (with a GMC ratio of 0.22) compared to BNT-IM, it resulted in fewer adverse drug reactions (39.26% vs. 64.68%) and no serious side effects were documented.
- - Both vaccines demonstrated similar efficacy against COVID-19 variants, but the study concluded that Ad5-nCoV-IH did not meet the non
Background: Medication burden and complexity have been longstanding problems in chronically ill patients. However, more data are needed on the extent and impact of medication burden and complexity in the transfusion-dependent thalassaemia population.
Aim: The aim of this study was to determine the characteristics of medication complexity and polypharmacy and determine their relationship with drug-related problems (DRP) and control of iron overload in transfusion-dependent thalassaemia patients.
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. The objective of the current study was to develop a sensitive, fast and high-throughput HPLC-ESI-MS/MS method to measure etoricoxib levels in human plasma using a one-step methanol protein precipitation technique. A tandem mass spectrometer equipped with an electrospray ionization (ESI) source operated in a positive mode and multiple reaction monitoring (MRM) were used for data collection.
View Article and Find Full Text PDFSample preparation and quantification of polar drug, allopurinol, in human plasma using LCMSMS.
Eur J Mass Spectrom (Chichester)
February 2022
A fast, selective and reproducible LC-MS/MS method with simple sample preparation was developed and validated for a polar compound, allopurinol in human plasma, using acyclovir as internal standard (IS). Chromatographic separation was achieved using Agilent Poroshell 120 EC-C (100 × 2.1 mmID, 2.
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