Publications by authors named "Sharon Roman"
Background: A growing body of compelling evidence has emerged to validate a set of signs and symptoms that indicates the onset of disease before more typical signs and symptoms present to fulfill a diagnosis of MS. On 24 June 2021, a group of international researchers, patient advocates, and Society representatives led by Professors Helen Tremlett (University of British Columbia) and Ruth Ann Marrie (University of Manitoba) convened virtually for a workshop.
Objective: Identify key gaps in knowledge, opportunities, and research priorities regarding the prodromal stage of MS.
Article Synopsis
- A prodrome refers to the early signs or symptoms of a disease that appear before the main symptoms emerge, and is recognized in various conditions like Parkinson's and type 1 diabetes.
- Recent findings suggest that multiple sclerosis (MS) also has a prodromal stage, which presents an opportunity for early intervention to potentially prevent or delay the onset of classical MS.
- There is still much to learn about the prodromal stage of MS, so more research is necessary to establish clear criteria for identifying individuals at high risk for developing MS, which could aid in future treatment trials.
Using clinically stable disease (NEDA 2) as a proxy for disease impact and employment in MS paints an incomplete picture.
J Neurol Neurosurg Psychiatry
January 2020