Telemetry discontinuation education for Nurse Practitioners decreases hospital costs-A quality-improvement project.

Background: Despite updated American Heart Association guidelines, interventions designed to reduce telemetry misuse are uncommon.

Local Problem: There was a systemic failure within the institution to adopt the most recent guidelines, resulting in poor use of resources and downstream costs.

Methods: Case-control.

The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.

Rationale: Escitalopram appears to be a superior antidepressant to racemic citalopram. It has been hypothesized that binding of R-citalopram to the serotonin transporter (SERT) antagonizes escitalopram binding to and inhibition of the SERT, there by curtailing the elevation of extracellular 5-hydroxytryptamine (5-HTExt), and hence anti-depressant efficacy. Further, it has been suggested that a putative allosteric binding site is important for binding of escitalopram to the primary, orthosteric, site, and for R-citalopram's inhibition here of.

AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.

Mutations in parkin and LRRK2 together account for the majority of familial Parkinson's disease (PD) cases. Interestingly, recent evidence implicates the involvement of parkin and LRRK2 in mitochondrial homeostasis. Supporting this, we show here by means of the Drosophila model system that, like parkin, LRRK2 mutations induce mitochondrial pathology in flies when expressed in their flight muscles, the toxic effects of which can be rescued by parkin coexpression.