Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients.

Objectives: To determine whether a novel Na+/H+ exchange ion inhibitor, zoniporide, is associated with reduced perioperative myocardial ischemic injury in high-risk surgery patients.

Design: Randomized double-blind placebo-controlled multidose trial.

Setting: Multicenter worldwide (105 centers) trial.