Rotavirus-Induced Expansion of Antigen-Specific CD8 T Cells Does Not Require Signaling TLR3, MyD88 or the Type I Interferon Receptor.

Rotavirus (RV) infection induces strong adaptive immunity. While protection from reinfection requires humoral immunity, initial clearance of infection depends on cytotoxic CD8 T cells. Type I classical dendritic cells (cDC1) excel at CD8 T cell induction through cross-presentation and are essential for optimal cytotoxicity towards RV.