Publications by authors named "Sharmin Al Haque"
Article Synopsis
- Lentiviral vectors (LV) are promising tools for gene therapy, but can lead to insertional mutagenesis, making it crucial to study their integration into host genomes.
- The research focuses on how transcription factors (TF) may influence the process of LV integration by mapping predicted binding sites near the insertion points chosen by HIV-1 LV in human induced pluripotent stem cells and their derivatives.
- Findings indicate that specific transcription factor binding sites (pTFBS) are enriched in the LV insertion sites and are essential for the HIV-1 life cycle, suggesting their importance in viral survival and propagation.
