Publications by authors named "Sharmila Salam"
Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality. The increased progression rate is closely associated with chronic liver diseases such as cirrhosis. Chemical carcinogens cause tumor advocacy over free radical metabolites to causes numerous biochemical and molecular changes that bring oxidative stress.
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- The study investigates the chemopreventive effects of boldine, an alkaloid from Peumus boldus, against liver cancer (HCC) induced by diethylnitrosamine (DEN) in Wistar rats.
- Boldine was found to protect liver cells from oxidative damage and enhance antioxidant enzyme activity, leading to reduced cellular proliferation markers associated with cancer.
- The research concludes that boldine may serve as an effective chemopreventive agent by modulating key proteins in the cell cycle and mitigating the harmful effects of reactive oxygen species.
Hepatocellular carcinoma (HCC) ranks the sixth position among various cancers worldwide. Recent research shows that natural and dietary compounds possess many therapeutic effects. Citral is a monoterpene aldehyde that contains geranial and neral.
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