Management of symptomatic irreversible pulpitis using irrigation agitation techniques in anterior teeth.

Endodontic pain, a common complication after root canal treatment, affects 2.5% to 60% of patients. Therefore, it is of interest to compare apical negative pressure irrigation (EndoVac) with conventional needle irrigation to assess their impact on postoperative pain in permanent anterior teeth with symptomatic irreversible pulpitis.

A comprehensive review on antibacterial analysis of natural extract-based metal and metal oxide nanoparticles.

Pharmaceutical, food packing, cosmetics, agriculture, energy storage devices widely utilize metal and metal oxide nanoparticles prepared via different physical and chemical methods. It resulted in the release of several dangerous compounds and solvents as the nanoparticles were being formed. Currently, Researchers interested in preparing nanoparticles (NPs) via biological approach due to their unique physiochemical properties which took part in reducing the environmental risks.

In vitro and in silico studies of silver nanoparticles (AgNPs) from Allium sativum against diabetes.

In the present study, the silver nanoparticles (AgNPs) were synthesized from the bulbs of Allium sativum, characterized by UV-visible spectroscopy, FT-IR, SEM, HR-TEM, EDAX analysis and investigated its action on the inhibition of starch digestion. The results proved that the biosynthesized nanoparticles were uniformly dispersed, spherical shaped with the size ranging from 10 to 30 nm. The phytochemical and FT-IR analysis showed the presence of phenols, terpenoids, and amino acids in the synthesized AgNPs.

Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma.

The purpose of the study is to determine the anti-proliferative and mitochondrial status of benzo(a)pyrene-induced lung cancer in Swiss albino mice, as well as the modulatory effect of vanillic acid on it. B(a)P had altered levels of lysosomal enzymes, xenobiotic-metabolizing enzymes, cell proliferation, inflammation, and mitochondrial abnormalities, whereas treatment with VA treatment significantly reversed the aforementioned activities. According to the findings, VA greatly reduces lung carcinogenesis by restoring antioxidants and xenobiotic-enzyme levels, consequently proving to be an anti-proliferative and anti-inflammatory drug against lung cancer in mice.

Variability of ENSO Forecast Skill in 2-Year Global Reforecasts Over the 20th Century.

In order to explore temporal changes of predictability of El Niño Southern Oscillation (ENSO), a novel set of global biennial climate reforecasts for the historical period 1901-2010 has been generated using a modern initialized coupled forecasting system. We find distinct periods of enhanced long-range skill at the beginning and at the end of the twentieth century, and an extended multi-decadal epoch of reduced skill during the 1930s-1950s. Once the forecast skill extends beyond the first spring barrier, the predictability limit is much enhanced and our results provide support for the feasibility of skillful ENSO forecasts up to 18 months.

Perioperative cardiovascular outcome in patients with coronary artery disease undergoing major vascular surgery: A retrospective cohort study.

Background: Major adverse cardiac events (MACE) are a major contributor to morbidity and mortality in patients undergoing major vascular surgeries. We aim to assess the incidence, risk factors, and outcome of MACE in patients with coronary artery disease (CAD) undergoing aortic surgeries.

Methods: In this retrospective observational study, we included patients with CAD who underwent elective major vascular surgery, namely, thoracoabdominal aortic aneurysm repairs and vascular bypass surgeries for aorto-occlusive disease, in our institute from January 2010 to December 2019.

Strategy to prevent infection from Covid-19 among security officers of tertiary care centre: A preexperimental study.

Background: The extensive spread of Covid-19 pandemic globally became the main cause of concern for everyone, including security officers working in a health care setting.

Objective: To assess the effectiveness of instructional module for Covid-19 prevention among hospital security officers.

Methods And Materials: A preexperimental study was conducted at a tertiary care hospital from North India.

Single collateral artery from descending thoracic aorta supplying pulmonary circulation-Computed tomography and echocardiographic images.

Pulmonary atresia (PA) with ventricular septal defect (VSD) is a rare congenital cardiac anomaly in which the pulmonary blood flow is supplied by major aorta pulmonary collateral arteries (MAPCAs). The complete repair includes unifocalization of MAPCAs, closure of VSD, and placement of a right ventricle-to-pulmonary artery conduit. We report a case of VSD with PA, where the computed tomography and echocardiography images described a large single collateral artery arising from descending thoracic aorta dividing into left and right branches and supplying the entire pulmonary circulation.

Transesophageal echocardiography guided optimal positioning of central venous catheter tip in superior vena cava during surgical repair of sinus venosus atrial septal defect.

Positioning of central venous catheter (CVC) tip in the intrathoracic portion of superior vena cava (SVC) is essential during the surgical repair of superior sinus venous atrial septal defects (SVASD). Although tracheal carina is described as a radiological landmark for positioning the tip of CVCs, it may not be successful at all times. We describe a case of SVC type SVASD, where the SVC-right pulmonary artery crossing point imaged on transesophageal echocardiography was used as an echocardiographic landmark for optimal positioning of the CVC tip.

Mechanisms of multiyear variations of Northern Australia wet-season rainfall.

Northern Australia wet season (November-April) rainfall exhibits strong variability on multiyear timescales. In order to reveal the underlying mechanisms of this variability, we investigate observational records for the period 1900-2017. At multiyear timescales, the rainfall varies coherently across north-western Australia (NW) and north-eastern Australia (NE), but the variability in these two regions is largely independent.

Pharmacognostic Assesment of the Endemic and Vulnerable Medicinal Climber- (Lam.) Gagnep. var. Gamble and Its Antibacterial Activity.

Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber var. and also screening the antibacterial activity of this climber.

Materials And Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed.

Bacterial lipid modification enhances immunoprophylaxis of filarial abundant larval transcript-2 protein in Mastomys model.

As in many other parasitic diseases, efficacious vaccine for lymphatic filariasis has been elusive for want of new approaches leaving billions of people either debilitated or at risk. With multiple B- and T-cell epitopes, the abundant larval transcript-2 (ALT-2) of the filarial worm, Brugia malayi, has been shown to be a promising immunoprophylactic target. To enhance its efficacy, it was lipid modified using our recently developed protein engineering tool, which then offered 30% more immunoprotection (49 vs.

Androgen receptor expression in human thyroid cancer tissues: a potential mechanism underlying the gender bias in the incidence of thyroid cancers.

Gender bias in the incidence of thyroid cancer is well known, however, the underlying mechanism is largely unknown. The current study determines variations in the molecular characteristics of thyroid cancers between men and women. Normal and cancerous thyroid tissues were collected from a total of 125 men and women who underwent surgical thyroidectomy.

The adjuvant-free immunoprotection of recombinant filarial protein Abundant Larval Transcript-2 (ALT-2) in Mastomys coucha and the immunoprophylactic importance of its putative signal sequence.

The filarial protein Abundant Larval Transcript-2 (ALT-2) of the filarial parasite Brugia malayi has been shown to produce 74% worm clearance when administered with an adjuvant. In the present study, we show that it not only induces humoral and cell-mediated immunity, but also protection up to 71% in Mastomys coucha, a permissive animal model for filariasis, even without adjuvant. This unique feature of ALT-2 protein is highly restricted to its 21 amino acid N-terminal signal sequence, the absence of which resulted in poor immune response as well as immunoprotection (49%).

Early HBeAg loss during peginterferon alpha-2b therapy predicts HBsAg loss: results of a long-term follow-up study in chronic hepatitis B patients.

Objectives: Treatment with pegylated interferon (PEG-IFN) alpha-2b results in hepatitis B e antigen (HBeAg) loss in 36% of patients at 6 months post treatment. The aim of this study was to determine whether a long-term response to PEG-IFN is dependent on the timing of HBeAg loss.

Methods: A total of 91 patients treated with PEG-IFN alpha-2b alone (100 microg per week) and 81 patients treated with PEG-IFN alpha-2b and lamivudine (100 mg/day) for 52 weeks were enrolled in this study.

Antibacterial efficacy and phytochemical observation of some Indian medicinal plants.

The aim of the study is to evaluate the antibacterial activity of Pistacia integerrima, Cedrus deodara and Gymnema sylvestre against seven different microorganisms such as Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas, Bacillus subtillis and Staphylococcus aureus by using disc diffusion method. Preliminary studies with ethanol extract and water extract of plants indicated that the growth of test organism was markedly inhibited by ethanol extract of Pistacia integerrima and Gymnema sylvestre. But in case of Cedrus deodara, water extract was more effective.

Isolated pure lipoma of the uterus--a case report.

Lipoma primary to uterus is a rare entity among uterine fatty tumors. These create preoperative diagnostic confusion and their histogenesis is still unclear. Only a few cases of pure lipoma of uterus have been reported in the last few decades.

Protective effect of Liv.52 and Liv.100, ayurvedic formulations on lipid peroxidation in rat liver homogenate--an in vitro study.

Liv.100 is an improvised herbal formulation of Liv.52.