A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes.

Background: Although curcumin's effect on head and neck cancer has been studied in vitro and in vivo, to the authors' knowledge its efficacy is limited by poor systemic absorption from oral administration. APG-157 is a botanical drug containing multiple polyphenols, including curcumin, developed under the US Food and Drug Administration's Botanical Drug Development, that delivers the active components to oromucosal tissues near the tumor target.

Methods: A double-blind, randomized, placebo-controlled, phase 1 clinical trial was conducted with APG-157 in 13 normal subjects and 12 patients with oral cancer.

Low-dose amitriptyline for treatment of persistent arm pain due to repetitive use.

Amitriptyline is sometimes used to treat arm pain related to repetitive use, but rigorous evidence of its benefit is lacking. This randomized controlled trial investigated whether amitriptyline provided greater pain relief or improved arm function than a placebo pill in adults with arm pain associated with repetitive use that had persisted for at least 3 months. Participants (N=118) were randomly assigned to receive 25mg of amitriptyline or a placebo pill for 6 weeks.

Latex paint-gun injuries of the hand: are the outcomes better?

This study aims to present the functional outcome in patients who sustained paint-gun injuries to the hand with latex paint and review the current trends, recommendations, and pitfalls of surgical treatment in contemporary literature. Five male patients with an average age of 35 years were treated between 2000 and 2003 after sustaining a paint-gun injury with latex paint. All wounds were located volarly on the digits of the nondominant hand.

Closed traumatic rupture of the extensor digitorum communis and extensor indicis proprius at the musculo-tendinous junction.

This report describes a closed rupture of the entire extensor digitorum communis and extensor indicis proprius.

Volar open reduction of complex metacarpophalangeal dislocation of the index finger: a pictorial essay.

Dislocations of the metacarpophalangeal joint are uncommon and usually caused by significant trauma. The distinction between subluxations and dislocations is critical. Complex dislocations require surgical reduction.