Publications by authors named "Sharmalee Selvaraji"
J Cereb Blood Flow Metab
December 2024
Article Synopsis
- Hypertension is a significant risk factor for both stroke and cognitive decline, but its specific impact on cognitive impairment after a stroke is still uncertain.
- In a study with C57BL/6J mice, researchers induced hypertension and then conducted strokes to assess cognitive outcomes using the Barnes maze and analyzed the brain's transcriptomic profile through RNA sequencing.
- Results indicated that hypertensive mice experienced worse cognitive performance and more brain injury compared to normotensive mice after a stroke, with over 1500 genes linked to neuroinflammation being differentially expressed.
