Gait-based Parkinson's disease diagnosis and severity classification using force sensors and machine learning.

A dual-stage model for classifying Parkinson's disease severity, through a detailed analysis of Gait signals using force sensors and machine learning approaches, is proposed in this study. Parkinson's disease is the primary neurodegenerative disorder that results in a gradual reduction in motor function. Early detection and monitoring of the disease progression is highly challenging due to the gradual progression of symptoms and the inadequacy of conventional methods in identifying subtle changes in mobility.

Palladium-Catalyzed Intramolecular C-H Amination via Oxidative Coupling on Indole Derivatives: Access to 11-Benzo[4,5]imidazo[1,2-]indoles.

A novel palladium-catalyzed intramolecular C-H amination via oxidative coupling exploiting inactivated N-substituted aryl amines on indoles for the one-pot synthesis of novel 11-benzo[4,5]imidazo[1,2-]indole derivatives is reported. The optimized reaction conditions accommodated a wide range of electronic variations on both the indole and the pendant aryl amine ring, resulting in products with good to excellent yields.

Google trend analysis of the Indian population reveals a panel of seasonally sensitive comorbid symptoms with implications for monitoring the seasonally sensitive human population.

Seasonal variations in the environment induce observable changes in the human physiological system and manifest as various clinical symptoms in a specific human population. Our earlier studies predicted four global severe seasonal sensitive comorbid lifestyle diseases (SCLDs), namely, asthma, obesity, hypertension, and fibrosis. Our studies further indicated that the SCLD category of the human population may be maladapted or unacclimatized to seasonal changes.

Unravelling land-based discharge of microplastics in River Basantar of Jammu & Kashmir, India: Understanding sinking behaviors and risk assessments.

Microplastics (MPs) are ubiquitous and are increasing globally, but there is limited information available on their presence in freshwater ecosystems. This research work aims to investigate the abundance, sinking behavior, and risk assessment of MPs in the freshwater River Basantar, Jammu & Kashmir, India. Microplastic abundance in sediments was recorded in the range of 1-6 items g, with a mean abundance of 3 ± 1.

Respiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: A systematic review and meta-analysis.

Several epidemiological studies have examined the respiratory consequences of occupational exposure to volatile organic compounds (VOCs). However, their effects on paint industry workers in organised and unorganised occupational sectors vary. The present systematic review and meta-analysis aim at evaluating the respiratory symptoms and pulmonary function of paint industry workers from various occupational sectors exposed to VOCs.

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies.

Alzheimer's disease (AD), the most common kind of dementia worldwide, is characterized by elevated levels of the amyloid-β (Aβ) peptide and hyperphosphorylated tau protein in the neurons. The complexity of AD makes the development of treatments infamously challenging. Apolipoprotein E (APOE) genes's ɛ4 allele is one of the main genetic risk factors for AD.

Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment.

Alzheimer's disease (AD) treatments currently available have ineffective results. Previously employed Acetylcholine esterase inhibitors and memantine, an NMDA receptor antagonist, target a single target structure that plays a complex role in the multifactorial progression of disease. Memantine moderates the toxic effects of excessive glutamate activity by blocking NMDA receptors, which decreases neurotoxicity in AD, while acetylcholine esterase inhibitors function by blocking cholinergic receptors (muscarinic and nicotinic), preventing the breakdown of acetylcholine, thereby enhancing cholinergic transmission, thus improving cognitive functions in mild to moderate stages of AD.

Utilization and associated factors of growth monitoring and promotion services among young children in Gorkha district of Nepal.

Introduction: Promotion of child health during the first thousand days from conception to the child's second birthday is vital for survival, growth and development. Growth monitoring and promotion services are key to the early detection of growth faltering and preventing malnutrition and promoting child health. This study aimed to assess the utilization of Growth Monitoring and Promotion (GMP) services and its associated factors among young children in Gorkha district of Nepal.

Frederick G Banting (1891-1941): A Pioneer in Diabetes Treatment.

The discovery of insulin by Frederick G Banting and his colleagues in 1921 marked a pivotal moment in medical history. Born in Ontario, Canada, in 1891, Banting's childhood was impacted by the death of his closest friend, Jane, who died of diabetes mellitus at a young age. This personal tragedy profoundly influenced him to choose a career in medicine and fueled his determination to find a cure for diabetes.

Flow-cytometric Analysis of Reactive Oxygen Species in Blood Cells: A Potential Tool for Predicting Restenosis - Insights from a Cohort Study.

Introduction: In-stent restenosis (ISR) is a recurrence of a blockage in a section of the coronary artery that has previously been treated with a stent. Molecular/biochemical pathways underlying ISR are not fully understood, but inflammation and reactive oxygen species (ROS) induced oxidative stress play a significant role in the pathogenesis of restenosis. As blood cells are highly sensitive to oxidative stress and blood is readily accessible compared to other tissues, the current study flow cytometrically investigated intracellular ROS and cytokine profile of blood cells as possible markers of restenosis.

Association Between Multivitamin Use on Admission and Clinical Outcomes in Patients Hospitalised with Community-Acquired Pneumonia: A Case-Cohort Study.

Background/objectives: Community-acquired pneumonia (CAP) is a leading cause of hospitalisations worldwide. Micronutrient deficiencies may influence CAP risk and severity, but their impact on CAP outcomes remains unclear. This study investigated the influence of multivitamin use on hospital length of stay (LOS), intensive care unit (ICU) admission, in-hospital mortality, and 30-day readmissions in hospitalised CAP patients.

Nanobubble nucleation by pulsed laser illumination of colloidal gold nanoparticles.

This study expands upon a technique our team previously developed for generating nanobubbles on demand with a collimated pulsed laser beam. This work highlights how the controlled addition of gold nanoparticles enhances nanobubble generation efficiency in water, even at laser intensities well below the threshold for multiphoton ionization. Specifically, we investigated the influence of nanoparticles of three distinct sizes on the laser fluence threshold for bubble nucleation and the lifetime of the resultant nanobubbles.

Behcet disease presenting as large and medium vessel occlusive disease.

We hereby present a case of a 34-year-old male patient diagnosed with Behcet's disease where computed tomography revealed the presence of thrombosis and occlusion of the infrarenal aorta and bilateral renal arteries. Such a pattern of vascular involvement is an unusual and uncommon manifestation of Behcet disease.

Deciphering adsorption behaviour and mechanisms of enhanced phosphate removal via optimized cetyltrimethylammonium bromide-modified nanofibrillated cellulose.

To combat the persistent environmental issues resulting from eutrophication, it is necessary to scavenge excess phosphorous levels from aquatic ecosystems. In response, a cationic adsorbent was prepared by modifying agrowaste-derived natural biomacromolecule; nanofibrillated cellulose (NFC) using cetyltrimethylammonium bromide (CTAB) surfactant. Comprehensive characterization through XRD, FTIR, HR-SEM, SEM-EDX, BET and XPS demonstrated that quaternizing NFC significantly improved its surface chemistry by introducing substantial quaternary ammonium groups.

The role of the neutrophil-to-lymphocyte ratio in predicting outcomes among patients with community-acquired pneumonia.

Objectives: The value of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcomes in patients hospitalised with community-acquired pneumonia (CAP) remains debated. This study evaluated whether NLR independently predicts clinical outcomes and enhances the predictive performance of the CURB-65 score in patients with CAP.

Methods: Data from CAP admissions at two Australian hospitals from 2018 to 2023 were analysed.

NELL-1 Associated Membranous Nephropathy - A Case Series from India.

Neural epidermal growth factor-like 1 (NELL-1) is responsible for a substantial proportion of cases of PLA2R-negative primary membranous nephropathy (MN). To investigate the occurrence, association, and treatment responses, we carried out this ambispective study. In the study, nine (10%) of all patients with MN at our center were found to be NELL-1 positive.

Relative humidity prediction across the Indian subcontinent using Kumaraswamy distribution based non-Gaussian model.

Relative humidity (RH) significantly influences various aspects of human life, including agriculture, weather prediction, indoor air quality, and energy consumption. Its intricate non-linear behavior poses a significant challenge for accurate estimation. In the context of Indian climate change, precise forecasting of RH is vital for agriculture and weather prediction.

Tracing the Trajectory of and Research: Eight Decades of Bibliometric Retrospect.

The global burden of mosquito-borne diseases transmitted by and mosquitoes has become a pressing public health concern. This study sought to quantify and evaluate about eight decades of publication data on the global epidemiological trend of the diseases transmitted by and . A comprehensive bibliographic review of literature was performed on and transmitted diseases, focusing on disease transmission, epidemiological trends, vector control strategies, surveillance and monitoring, and international collaborations and initiatives.

Perceptions of a Cardiovascular Risk Reduction Intervention for Sexual Minority Adults.

Sexual minority (SM) adults have a higher prevalence of risk factors for cardiovascular disease (CVD), largely attributable to increased exposure to minority stressors. There are no evidence-based CVD risk reduction interventions tailored to the needs of SM adults. We conducted a qualitative descriptive study to explore SM adults' perceptions and preferences for a culturally tailored, minority stress-informed intervention for CVD risk reduction.

Assessment of Antenatal Care Services Utilization and Its Associated Factors.

Background: Every pregnant woman supposed to have Antenatal care visits at least four times during 4th, 6th, 8th and 9th month of gestation. This contributes to the reduction in maternal mortality. The main objective of the study was to assess the utilization of antenatal care services and its associated factors in Pokhara Metropolitan.

Unraveling the Mysteries of Alzheimer's Disease Using Artificial Intelligence.

Alzheimer's disease (AD) is a multidimensional, complex condition that affects individuals all over the world. Despite decades of experimental and clinical research that has revealed various processes, many concerns concerning the origin of Alzheimer's disease remain unresolved. Despite the notion that there isn't a complete set of jigsaw pieces, the growing number of public data-sharing initiatives that collect biological, clinical, and lifestyle data from those suffering from Alzheimer's disease has resulted in virtually endless volumes of knowledge about the disorder, far beyond what humans can comprehend.

Physical Therapy for Patients with Thoracolumbar Vertebral Fractures.

Vertebral fractures are a common cause of back pain and pain-related functional impairments in elderly patients. Despite their widespread occurrence, vertebral fractures frequently remain underdiagnosed, often leading to suboptimal management and poor clinical outcomes. This review specifically examines the role of physical therapy (PT) in managing vertebral fractures, describing current literature and evidence-based guidelines from the American Physical Therapy Association and the American Academy of Orthopaedic Surgeons.

Vocal tasks-based EEG and speech signal analysis in children with neurodevelopmental disorders: a multimodal investigation.

Neurodevelopmental disorders (NDs) often hamper multiple functional prints of a child brain. Despite several studies on their neural and speech responses, multimodal researches on NDs are extremely rare. The present work examined the electroencephalography (EEG) and speech signals of the ND and control children, who performed "Hindi language" vocal tasks (V) of seven different categories, viz.