Publications by authors named "Sharma Saurabh"

Background: This study aims to address the lack of substantial evidence regarding the effect of COVID-19 on maternal and child health (MCH) services in India and also highlight the role of primary care physicians in maintaining essential services during a pandemic. While studies conducted worldwide and in India have examined the effects of COVID-19 on these services, a significant gap in robust evidence remains.

Methods: Forty-two districts were selected randomly from seven regional states of India.

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Introduction: In April 2005, under the umbrella of National Rural Health Mission (NRM) in response to the slow and varied progress in improvement of maternal and neonatal health, the Government of India launched a scheme known as Janani Suraksha Yojana (ISY).

Objectives: With the help of this study, we intend to understand the knowledge, source of information, awareness, and barriers to acceptance of JSY among women in Western Uttar Pradesh and conduct a SWOT analysis for the same.

Material And Methods: The sample size was 300 and calculated using the prevalence of institutional delivery taken from National Family Health 2015-16 Survey (NFHS-4) in Uttar Pradesh, India, which was 67.

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Background: Mortality statistics are vital for health policy development, epidemiological research, and health care service planning. A robust surveillance system is essential for obtaining vital information such as cause of death (CoD) information.

Objective: This study aims to develop a comprehensive model to strengthen the CoD information in the selected study sites.

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 This study aimed to evaluate the status of sleep, chronotype, and related variables of university athletes with and without chronic low back pain (CLBP), to find the correlation between CLBP, sleep difficulty score (SDS), and chronotype, and to determine if SDS and chronotype predict CLBP.  Ninety-two university athletes [46 with CLBP (Age: 22.08±2.

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Thermo-mechanically stabilized nanocrystalline (NC) alloys are increasingly valued for their enhanced mechanical strength and high-temperature stability, achieved through thermodynamic and kinetic stabilization methods. However, their fine-grained structure also increases susceptibility to internal oxidation due to higher atomic diffusivity associated with a greater volume fraction of grain boundaries (GBs). By incorporating solutes that form protective oxides, or the so-called thermally growing oxides (TGO), this vulnerability can be mitigated.

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Article Synopsis
  • Glioblastoma (GBM) is a highly aggressive brain cancer, making up about 80% of malignant brain tumors, and currently lacks effective treatments due to its complexity and the blood-brain barrier.
  • Traditional 2D models do not accurately represent the tumor microenvironment, leading to a growing interest in organ-on-a-chip (OoC) models that mimic human tissue and offer better insights into disease and drug responses.
  • The review discusses the advancements in GBM-on-a-chip models, their applications in drug development, and highlights the challenges and future directions for enhancing these innovative research platforms.
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  • * This study evaluated the intra-rater reliability of GaitON by analyzing 20 healthy participants' gait and posture over two sessions, one week apart, using video and image recordings.
  • * Results showed excellent reliability for both gait and posture measurements, with high intraclass correlation coefficients (above 0.90), indicating that GaitON is a dependable tool for clinical assessments.
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Background And Objective: Non-specific chronic low back pain (NSCLBP) is a prevalent condition causing significant disability and functional impairment. Whole-body vibration exercise (WBVE) has emerged as a new treatment method, but additional research is necessary to determine the optimal parameters of WBVE that would be beneficial for patients experiencing chronic low back pain (CLBP). This study aims to investigate the effects of two type of WBVE (constant progressive) on pain, disability, functional performance, and muscle activity in patients with NSCLBP.

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  • The hallmark features of Alzheimer's disease (AD) include the build-up of tau tangles and beta-amyloid deposits, leading to memory loss and cognitive decline.
  • Alzheimer's is primarily hereditary and presents in various forms, impacting primarily middle-aged and older adults while being influenced by other neurodegenerative disorders.
  • Researchers are focusing on developing multi-target-directed ligands (MTDLs), which target multiple mechanisms of AD, including oxidative stress and inflammation, to create more effective drug candidates, particularly using combinations of existing compounds.
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Water is a vital component of our existence. Many human activities, such as improper waste disposal from households, industries, hospitals, and synthetic processes, are major contributors to the contamination of water streams. It is the responsibility of every individual to safeguard water resources and reduce pollution.

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Introduction: Reducing childhood mortality by curtailing the incidence of vaccine preventable diseases is contingent upon a robust and high-performing routine immunization system. According to the available data, the full immunization coverage (FIC) in the state of Bihar (India) has reached ~ 71%. While the government aspires to reach 90% FIC, a systematic evidence-based investigation of the reasons behind underimmunization as well as the identification of drivers and enablers to reach and sustain 90% FIC is critical.

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Background: Transcatheter aortic valve replacement (TAVR) being currently employed in low surgical risk patients with severe symptomatic aortic stenosis (AS). The durability and extended outcomes of TAVR as compared to surgical aortic valve replacement (SAVR) in low-risk patients remains uncertain.

Methods: We selected randomized controlled trials (RCT) comparing outcomes of TAVR vs.

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Walking is a fundamental physical activity with significant health implications. Backward gait training (BGT) has emerged as a novel approach with potential benefits, yet its effects in comparison to traditional forward gait training (FGT) remain uncertain. This systematic review and meta-analysis aimed to evaluate the effects of BGT on body composition, cardiopulmonary fitness, and inflammatory and metabolic markers in adults.

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Type 2 diabetes mellitus (T2DM) often leads to cardiac autonomic neuropathy (CAN), a severe complication affecting cardiovascular health. Exercise training is a proven intervention for improving metabolic control and cardiovascular health in T2DM, but the effects of concurrent exercise training (CET), combining aerobic and resistance exercises, on CAN are not fully understood. This randomized controlled trial investigates the impact of a structured CET program on cardiac autonomic modulation, metabolic profile, body composition, cardiorespiratory fitness (CRF), and quality of life (QoL) in individuals with T2DM and CAN.

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This study aims to focus on developing a food supplement for the geriatric population using disposal mushrooms, oats, and lactose-free milk powder. Lactose intolerance is most common in older adults, raising the demand for lactose-free foods. One of the major global challenges currently faced by humankind is food waste (FW).

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The host immune responses play a pivotal role in the establishment of long-term memory responses, which effectively aids in infection clearance. However, the prevailing anti-tuberculosis therapy, while aiming to combat tuberculosis (TB), also debilitates innate and adaptive immune components of the host. In this study, we explored how the front-line anti-TB drugs impact the host immune cells by modulating multiple signaling pathways and subsequently leading to disease relapse.

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Article Synopsis
  • Despite India's successful COVID-19 vaccination campaign, many adults remain unvaccinated or have only had one dose, indicating a significant vaccine hesitancy issue.
  • The study conducted in Gorakhpur, Uttar Pradesh, utilized multiple health behavior models to analyze the psychological and behavioral factors influencing this hesitancy.
  • Key findings revealed that negative attitudes towards the vaccine greatly increase hesitancy, while enhancing public awareness about vaccine benefits and building trust could help combat this issue.
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Non-specific chronic low back pain (NSCLBP) presents significant treatment challenges due to its multifactorial nature. Whole-body vibration exercise (WBVE) has emerged as a potential therapeutic modality, offering benefits across various domains, including pain reduction, improved balance, and enhanced quality of life (QoL). The aim of this present systematic review and meta-analysis is to evaluate the effects of WBVE on pain, disability, balance, proprioception, functional performance, and QoL in individuals with NSCLBP.

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Correction for 'Integrated biosensors for monitoring microphysiological systems' by Lei Mou , , 2022, , 3801-3816, https://doi.org/10.1039/D2LC00262K.

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Background: A link between pronated feet (PF) and chronic low back pain (CLBP) has been reported in the literature. However, physical interventions (PI) like physiotherapy and orthotics mainly target the lower back, neglecting the broader biomechanical impacts of PF that affect the feet, ankles, and overall posture. Currently, there is a lack of comprehensive meta-analyses or systematic reviews on this subject.

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Background: Fungal infections are now a great public health threat, especially in those with underlying risk factors such as neutropenia, diabetes, high-dose steroid treatment, cancer chemotherapy, prolonged intensive care unit stay, and so on, which can lead to mycoses with higher mortality rates. The rates of these infections have been steadily increasing over the past 2 decades due to the increasing population of patients who are immunocompromised. However, the data regarding the exact burden of such infection are still not available from India.

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