Publications by authors named "Sharma Pankaj"

Domain walls are quasi-one-dimensional topological defects in ferroic materials, which can harbor emergent functionalities. In the case of ferroelectric domain wall (FEDW) devices, an exciting frontier has emerged: memristor-based information storage and processing approaches. Memristor solid-state FEDW devices presented thus far, however predominantly utilize a complex network of domain walls to achieve the desired regulation of density and charge state.

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Background: Anthropometric measurements used to predict cardiovascular disease vary worldwide but are mostly derived from those of Caucasian ancestry. We sought to undertake such measurements in the little studied Bangladeshi population.

Methods: The MAGPIE (Multidimensional Approach of Genotype and Phenotype in Stroke Etiology) study is a Bangladeshi stroke case-control study that recruited nationwide between January 2022 and June 2024.

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Four mononuclear bioefficient zinc coordination complexes [Zn(NN)](ClO) (-) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, H, and C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against , , and , displaying varying levels of growth inhibition.

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Big data and artificial intelligence are driving increasing demand for high-density data storage. Probe-based data storage, such as mechanical storage using an atomic force microscope tip, is a potential solution with storage densities exceeding hard disks. However, the storage medium must be modifiable on the nanoscale.

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Objective: High fibrinogen levels are associated with an increased risk of ischaemic stroke (IS). We used mendelian randomisation (MR) to explore a potential causal relationship.

Materials And Methods: Data for assessing the relationship between gene variant, disease and biological levels needed for a MR approach was collected using a meta-analytical approach.

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Background And Aims: Stroke is a leading cause of mortality and morbidity in Bangladesh. It is estimated that genetic determinants account for around 40%-60% of its etiology, similar to environmental factors. This study aimed to provide a better understanding of the genetic, environmental, and clinical risk factors in stroke patients from Bangladesh.

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Tooth loss is a prevalent problem faced by individuals of all ages across the globe. Various biomaterials, such as metals, bioceramics, polymers, composites of ceramics and polymers, etc., have been used for the manufacturing of dental implants.

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Article Synopsis
  • * There is a need for more research to identify new therapeutic targets, as current genetic and transcriptomic information on T-ALL is lacking.
  • * Long non-coding RNAs are being recognized as critical factors in cancer growth and could play a role in T-ALL by serving as potential biomarkers and therapeutic targets for better diagnosis and treatment.
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  • - RNA modification is essential for controlling post-transcriptional processes, with N6-Methyladenosine (m6A) being the most common type, involving 'writers', 'readers', and 'erasers' that manage its regulation and impact mRNA stability and translation.
  • - The discovery of 'erasers', or demethylases, showed that RNA modifications can be reversed, leading to increased research on m6A's role in various diseases, particularly cancers, where disruptions in these regulating components can upset cellular balance.
  • - Specifically, in acute leukemias—which are prevalent in children and significant in adults—research indicates that abnormal expression of the m6A regulatory complex contributes to disease progression, making
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Multivalent meningococcal conjugate vaccines are a significant focus for the scientific community in light of the WHO's mission to defeat meningitidis by 2030. Well-known meningococcal vaccines such as MenAfriVac, Nimenrix, Menveo, and MenQuadfi are licensed in various parts of the world and have been successful. Recently, the World Health Organization (WHO) qualified MenFive (meningococcal A, C, Y, W, and X) conjugate vaccine, further enhancing the battery of vaccines against meningitis.

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Lumbar radiculopathy is one of the most common disorders encountered by a spine surgeon. The condition involves back pain, which may radiate to the lower limbs, and neurological symptoms, which involve a specific nerve root. Caudal epidural steroid injections (CESIs) and selective nerve root blocks (SNRBs) are two of the most common interventions, which are used to control the pain and neurological symptoms associated with chronic lumbar radiculopathy.

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This paper explores the life and contributions of Dr. Paul Harrington, a pioneering figure in spinal surgery, mainly known for his groundbreaking work in treating scoliosis. It delves into the development and impact of the Harrington rod, a revolutionary device that transformed the surgical management of spinal deformities.

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Introduction In nuclear medicine, there is a critical need to balance the control and optimization of radiation doses to ensure patient safety while achieving high-quality diagnostic outcomes. However, diagnostic reference levels (DRLs) for nuclear medicine imaging studies have not been established in India. This study aims to fill this gap by establishing institutional DRLs and assessing radiation dose data specifically for Nuclear Medicine SPECT examinations.

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Introduction: Intertrochanteric fractures are one of the most common fractures around the pelvis and hip joint. Intrerotrochanteric fracture commonly occurs in elderly adult as a result of a simple domestic fall or slippage due to osteoporosis and young adult due to high-energy trauma. In 1990, 26% of all intertrochanteric fractures were reported in Asia, this figure is estimated to 32% in 2025 and 38% in 2050.

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The polyphagous phytopathogen Sclerotinia sclerotiorum causing Stem rot disease is a major biotic stress in Brassica, and affects the yield and quality in various crops of agricultural significance. It affects the crop at pre-maturity which causes a reduction in the seed yield and deteriorates the oil quality in rapeseeds and Indian mustard globally. The hemibiotrophic nature and long persistence in the soil as sclerotia have made this pathogen difficult to manage through conventional agronomical practices.

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Background: Transport porters (TPTs) are essentially involved in supporting hospital operations and maintaining high-quality patient care. The traditional porter management lacks transmission of temporal and spatial information of the porters thus affecting porter operations. In this work, we investigate the barriers in traditional porter management and the impact of a real-time location system (RTLS) in improving time and cost efficiency for porter operations.

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Article Synopsis
  • Posterior ring apophyseal fracture (PRAF) is a rare injury in teens that can cause lower back pain and nerve issues, often due to sports or trauma.
  • A case study highlights a 13-year-old girl with PRAF and lumbar disc herniation after a sports injury, showcasing the diagnostic and surgical challenges.
  • She underwent a minimally invasive surgery and showed significant improvement in pain levels one month later, emphasizing the importance of proper imaging and treatment for similar injuries in adolescents.
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  • Ankle fractures involving the posterior malleolus can significantly impair function, leading to ongoing debate over the best surgical approach: the traditional posteromedial (PM) or the newer posterolateral (PL) technique.
  • A study conducted with 42 patients randomly assigned to either the PL or PM approach showed that those in the PL group had better early clinical outcomes and fewer complications, as measured by AOFAS scores and range of motion.
  • While the PL approach yielded superior results at six and twelve months, the long-term differences between the two groups were not statistically significant at the final follow-up.
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van der Waals ferroelectric CuInPS (CIPS) has drawn significant attention not only because of its unique properties but also owing to its technological potential for nanoelectronics. Mechanical polarization switching provides a new approach to modulating polarization states through flexoelectricity. This approach is particularly favourable for CIPS to avoid surface damage under an electric field due to the coupling between polarization switching and ionic motion.

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  • - Cancer predisposition syndromes (CPS) are genetic disorders that raise cancer risk, yet many children in low- and middle-income countries go undiagnosed, impacting treatment and family counseling.
  • - In a study of 60 pediatric oncology patients, six were identified with CPS, confirmed through whole exome sequencing that detected germline mutations in five cases, including two novel mutations.
  • - The study found a 10% prevalence of CPS among the patients and suggests that using specific selection criteria for screening could improve diagnosis and treatment modifications in pediatric cancer patients in LMIC settings.
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  • The study aimed to evaluate the effectiveness of a specific surgical technique (PHILOS plate) for treating different types of proximal humerus fractures.
  • It included 27 patients over one year, assessing their recovery using standardized scoring methods, while excluding cases with complications or other severe injuries.
  • Results showed that most patients had good to excellent outcomes, with minimal complications, suggesting PHILOS plating is a reliable treatment option for these fractures.
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  • A lot of people are getting metabolic syndrome, which can lead to a disease called non-alcoholic fatty liver disease (NAFLD) that happens when fat builds up in the liver.
  • Researchers looked for drugs that can stop an enzyme called SCD1, which helps create fat in the liver, using a special database and computer models.
  • They found that a drug called Montelukast seems to help lower fat in the liver and reduce damage caused by free radicals, suggesting it could be a good treatment for NAFLD.
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Aim: The post-operative sequelae of third molar surgical extractions need to be controlled in order to reduce patient morbidity. Dexamethasone is a well-researched drug which has established its merit as an anti-inflammatory agent. The aim of this randomized clinical study was to compare the patient-centric outcomes after pre-emptive intramuscular injection of dexamethasone into the masseter and deltoid, respectively.

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