Remediation of Cd and Cu contaminated water and soil using novel nanomaterials derived from sugar beet processing- and clay brick factory-solid wastes.

Producing nanomaterials from hazardous wastes for water and soil treatment is of great concern. Here, we produced and fully characterized two novel nanomaterials from sugar beet processing (SBR)- and brick factory-residuals (BFR) and assed their ability for Cd and Cu sorption in water and reducing metal availability in a contaminated soil. The SBR removed up to 99% of Cu and 91% of Cd in water, and exhibited a significantly faster and higher sorption capacity (q (g kg) = 1111.

Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials.

DsbA enzymes catalyze oxidative folding of proteins that are secreted into the periplasm of Gram-negative bacteria, and they are indispensable for the virulence of human pathogens such as Vibrio cholerae and Escherichia coli. Therefore, targeting DsbA represents an attractive approach to control bacterial virulence. X-ray crystal structures reveal that DsbA enzymes share a similar fold, however, the hydrophobic groove adjacent to the active site, which is implicated in substrate binding, is shorter and flatter in the structure of V.

CRISPR use in diagnosis and therapy for COVID-19.

Since the beginning of the COVID-19 pandemic, many diagnostic approaches (RT-qPCR, RAPID, LFA) have been adopted, with RT-qPCR being the most popular/gold standard. But, one of the major problems of COVID-19 diagnostics is the presentation of a wide range of symptoms which varies among different patients and needs early diagnosis for better management. Even though RT-qPCR is a precise molecular technique false negative results may be obtained.

Role of the Tumor Microenvironment and the Influence of Epigenetics on the Tumor Microenvironment in Oral Carcinogenesis: Potential Implications.

Oral cancer has become a significant problem throughout the world, particularly in countries that are still developing. Recent literature supports the contribution of components of the tumor microenvironment (TME) and the effect of epigenetic changes happening in the cells of the TME on oral cancer development and progression. In this review, we comprehensively examine the significance of TME in the development of OC along with the current understanding of the epigenetic modifications that regulate the TME and their cohesive impact on tumor traits and their potential as therapeutic targets.

CRISPR/Cas9: A Molecular Tool for Ovarian Cancer Management beyond Gene Editing.

Ovarian cancer manifests with early metastases and has an adverse outcome, impacting the health of women globally. Currently, this malignancy is often treated with cytoreductive surgery and platinum-based chemotherapy. This treatment option has a limited success rate due to tumor recurrence and chemoresistance.

A real-world study of wearable sensors in Parkinson's disease.

Most wearable sensor studies in Parkinson's disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observational study, we assessed motor features using wearable sensors developed by MC10, Inc.

A comprehensive review on the removal of noxious pollutants using carrageenan based advanced adsorbents.

Rapid industrial development is associated with high discharge of toxic pollutants into the environment. The industries discharge their wastewater containing organic pollutants directly into the water system without treating them that has posed many serious threats to environmental protection. The use of bioadsorbents for the removal of such toxic pollutants from the waste water due to its simple synthesis, easy operation, effectiveness, and economic viability have emerged a new dimension in the wastewater treatment approaches.

Accelerated charge transfer in well-designed S-scheme Fe@TiO/Boron carbon nitride heterostructures for high performance tetracycline removal and selective photo-reduction of CO greenhouse gas into CH fuel.

Designing and fabrication of smart hybrid multifunctional materials for energy/fuel production and environmental detoxification is indeed of great significance for sustainable development. Herein, we synthesized a new well-structured S-scheme heterostructure Fe@TiO/Boron Carbon nitride (FT/BCN) with high performance tetracycline degradation and selective CO photo-reduction to CH. Under visible light irradiation, 96.

MXenes based nano-heterojunctions and composites for advanced photocatalytic environmental detoxification and energy conversion: A review.

Extensive research is being done to develop multifunctional advanced new materials for high performance photocatalytic applications in the field of energy production and environmental detoxification, MXenes have emerged as promising materials for enhancing photocatalytic performance owing to their excellent mechanical properties, appropriate Fermi levels, and adjustability of chemical composition. Numerous experimental and theoretical research works implied that the dimensions of MXenes have a significant impact on their performance. For photocatalysis to thrive in the future, we must understand the current state of the art for MXene in different dimensions.

Vitality of Proteinase K in rRTPCR Detection of SARS-CoV2 Bypassing RNA Extraction.

This study aimed to detect the SARS-COV2 viral component directly from inoculated VTM without RNA extraction. Inoculated VTMs of already tested 50 positive and 50 negative samples were divided into three groups. Group I was treated with Proteinase K (PK) followed by 3-step-heat treatment at different temperatures (25°C, 60°C, and 98°C) and stored at 4°C.

Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women.

Background & Objectives: Local angiogenesis in endometrium has been shown to be an essential pre-requisite for endometrial receptivity needed for implantation and gestation. Recently, numerous diagnostic gears have been projected to 'measure' or 'estimate' the endometrial receptivity relying upon angiogenic factors helping throughout implantation. This study evaluated the endometrial and subendometrial blood flow and the local endometrial gland vascular endothelial growth factor (EG-VEGF) expression as markers of local angiogenesis.

Co-Polarized [1-C]Pyruvate and [1,3-C]Acetoacetate Provide a Simultaneous View of Cytosolic and Mitochondrial Redox in a Single Experiment.

Cellular redox is intricately linked to energy production and normal cell function. Although the redox states of mitochondria and cytosol are connected by shuttle mechanisms, the redox state of mitochondria may differ from redox in the cytosol in response to stress. However, detecting these differences in functioning tissues is difficult.

Plasma Hydrogen Sulfide Is Positively Associated With Post-operative Survival in Patients Undergoing Surgical Revascularization.

Hydrogen sulfide (HS) is a gaseous signaling molecule and redox factor important for cardiovascular function. Deficiencies in its production or bioavailability are implicated in atherosclerotic disease. However, it is unknown if circulating HS levels differ between vasculopaths and healthy individuals, and if so, whether HS measurements can be used to predict surgical outcomes.

Redox ticklers and beyond: Naphthoquinone repository in the spotlight against inflammation and associated maladies.

Cellular redox status has been considered as a focal point for the pathogenesis of multiple disorders. High and persistent levels of free radicals kick off inflammation and associated disorders. Though oxidative stress at high levels is harmful but at low levels it has been shown to exert cytoprotective effects.

Precipitation of (Mg/Fe-CTAB) - Layered double hydroxide nanoparticles onto sewage sludge for producing novel sorbent to remove Congo red and methylene blue dyes from aqueous environment.

Preparation of new sorbent from precipitation of nano-sized (Mg/Fe-CTAB)- layered double hydroxide (LDH) on the surfaces of sewage sludge byproduct to remove the anionic and cationic dyes was the focal point of this work. The presence of nanoparticles and enlarged of interlayers by CTAB intercalation have increased the sludge surface area from 5.34 to 10.

Identification and characterization of DNA aptamers specific to VP2 protein of canine parvovirus.

Canine parvovirus-2 (CPV-2) is ubiquitously distributed in dog population worldwide causing a severe and often fatal gastroenteritis. Owing to its highly contagious nature, rapid detection of CPV is crucial in effective control of the disease. Aptamers have emerged as potential alternative to antibodies as affinity reagents in diagnostic field.

Analysis of maternal and newborn training curricula and approaches to inform future trainings for routine care, basic and comprehensive emergency obstetric and newborn care in the low- and middle-income countries: Lessons from Ethiopia and Nepal.

Program managers routinely design and implement specialised maternal and newborn health trainings for health workers in low- and middle-income countries to provide better-coordinated care across the continuum of care. However, in these countries details on the availability of different training packages, skills covered in those training packages and the gaps in their implementation are patchy. This paper presents an assessment of maternal and newborn health training packages to describe differences in training contents and implementation approaches used for a range of training packages in Ethiopia and Nepal.

Functional outcome in patients with Charcot neuropathy with almost complete loss of talus treated by tibio-talo calcaneal nail: A cross-sectional study.

Introduction: Tibio-talo-calcaneal (TTC) fusion is a successful surgery for Charcot neuropathy affecting the hindfoot. A case series of Charcot neuropathy is presented with almost complete loss affecting hindfoot treated with tibio-talo-calcaneal nail.

Material And Methods: Seven patients with Charcot neuropathy of the hindfoot having varying degrees of talus loss underwent tibio-talo-calcaneal nailing between January 2014 and Feb 2016 at a tertiary care hospital by a single surgeon.

Will open waste burning become India's largest air pollution source?

India struggles with frequent exceedances of the ambient air quality standard for particulate matter and benzene. In the past two decades, India has made considerable progress in tackling indoor air pollution, by phasing out kerosene lamps, and pushing biofuel using households towards Liquefied Petroleum Gas (LPG) usage. In this study, we use updated emission inventories and trends in residential fuel consumption, to explore changes in the contribution of different sectors towards India's largest air pollution problem.

Moonlighting Biochemistry of Cysteine Synthase: A Species-specific Global Regulator.

Cysteine Synthase (CS), the enzyme that synthesizes cysteine, performs non-canonical regulatory roles by binding and modulating functions of disparate proteins. Beyond its role in catalysis and regulation in the cysteine biosynthesis pathway, it exerts its moonlighting effect by binding to few other proteins which possess a C-terminal "CS-binding motif", ending with a terminal ILE. Therefore, we hypothesized that CS might regulate many other disparate proteins with the "CS-binding motif".

Outlet Ventricular Septal Defect in an Elderly Male.

Ventricular septal defect (VSD) is the most common congenital cardiac anomaly in children and the second most common congenital cardiac anomaly in adults. The hemodynamic compromise associated with VSD is due to the shunt formation created by the abnormal communication between the right and left ventricles. While 85%-90% of small VSDs close spontaneously during the first year of life, some do not close spontaneously.

Complete genome sequence and identification of polyunsaturated fatty acid biosynthesis genes of the myxobacterium Minicystis rosea DSM 24000.

Background: Myxobacteria harbor numerous biosynthetic gene clusters that can produce a diverse range of secondary metabolites. Minicystis rosea DSM 24000 is a soil-dwelling myxobacterium belonging to the suborderSorangiineae and family Polyangiaceae and is known to produce various secondary metabolites as well as polyunsaturated fatty acids (PUFAs). Here, we use whole-genome sequencing to explore the diversity of biosynthetic gene clusters in M.

Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: A systematic review and meta-analysis.

Objective: Anxiety symptoms are highly prevalent among individuals with bipolar disorder (BD) but there is little guidance on pharmacotherapy for these symptoms. The objective of this systematic review and meta-analysis was to evaluate the available evidence for pharmacotherapy of comorbid anxiety symptoms in BD.

Methods: Completed randomized clinical trials (RCTs) of medications for BD published prior to December 2020 were identified through a systematic search of MEDLINE, Embase, PsycInfo, Web of Science, clinicaltrials.

What Is the Most Reliable Method of Measuring Glenoid Bone Loss in Anterior Glenohumeral Instability? A Cadaveric Study Comparing Different Measurement Techniques for Glenoid Bone Loss.

Background: Preoperative quantification of bone loss has a significant effect on surgical decision making and patient outcomes. Various measurement techniques for calculating glenoid bone loss have been proposed in the literature. To date, no studies have directly compared measurement techniques to determine which technique, if any, is the most reliable.

Adsorptional-photocatalytic removal of fast sulphon black dye by using chitin-cl-poly(itaconic acid-co-acrylamide)/zirconium tungstate nanocomposite hydrogel.

In the present work, the removal of fast sulphon black (FSB) dye from water was executed by using chitin-cl-poly(itaconic acid-co-acrylamide)/zirconium tungstate nanocomposite hydrogel (Ch-cl-poly(IA-co-AAm)-ZrW NCH). The Ch-cl-poly(IA-co-AAm)-ZrW NCH was fabricated proficiently by microwave-induced sol-gel/copolymrization method. The zirconium tungstate (ZrW) photocatalyst was prepared by co-precipitation method using sodium tungstate and zirconium oxychloride in ratio (2:1).