Green Synthesis of Eosin-Y Coated Silver Nanoparticles for Sensitive and Selective Fluorometric Detection of L-Dopa.

This study is to produce biogenic silver nanoparticles (AgNPs) by utilizing aqueous extracts derived from Turnera Sublata (TS) leaves under visible light. Subsequently, these nanoparticles are coated with eosin-yellow (EY) to enhance sensitivity and selectivity in L-3,4-dihydroxyphenylalanine (L-dopa) detection. This method encompasses the deposition of metal onto the Ag NPs, resulting in the formation of EY-AgNPs.

Controlled Nitrogen Release by Hydroxyapatite Nanomaterials in Leaves Enhances Plant Growth and Nitrogen Uptake.

Nitrogen fertilizer delivery inefficiencies limit crop productivity and contribute to environmental pollution. Herein, we developed Zn- and Fe-doped hydroxyapatite nanomaterials (ZnHAU, FeHAU) loaded with urea (∼26% N) through hydrogen bonding and metal-ligand interactions. The nanomaterials attach to the leaf epidermal cuticle and localize in the apoplast of leaf epidermal cells, triggering a slow N release at acidic conditions (pH 5.

Predictors of Encephalitis in Children with Scrub Typhus-Associated Acute Febrile Illness.

Scrub typhus (ST) is an emerging public health concern in India. Despite being treatable, 20-30% of acute febrile illnesses (AFI) progress to encephalitis in endemic regions. This study aimed to identify early markers for encephalitis development in children hospitalized with AFI and positive Orientia tsutsugamushi (Ots) serology.

Copigmentation effect on red cabbage anthocyanins, investigation of their cellular viability and interaction mechanism.

Anthocyanins (ANS) are an appealing substitute to synthetic colorants; but their practical applicability is limited due to low color stability. Copigmentation can improve both complex's color stability as well as intensity. In this study, we examined the interaction of red cabbage ANS with copigments i.

Patterns of Brain Injury and Clinical Outcomes Related to Trauma from Collisions Involving Motor Vehicles.

: Despite improvements in technology and safety measures, injuries from collisions involving motor vehicles (CIMVs) continue to be prevalent. Therefore, our goal is to investigate the different patterns of head injuries associated with CIMVs. : This is a single-center, retrospective study of patients with motor vehicle-related trauma between 1 January 2016-31 December 2023.

Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis.

Metarrestin (ML246) is a first-in-class pyrrole-pyrimidine-derived small molecule that selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear structure predominantly found in solid tumor cells. The occurrence of PNC demonstrates a positive correlation with malignancy, serving as an indicator of tumor aggressiveness, progression, and metastasis.

Lactate Is a Strong Predictor of Poor Outcomes in Patients with Severe Traumatic Brain Injury.

Lactate is a byproduct of glycolysis, often linked to oxygen deprivation. This study aimed to examine how lactate levels (LLs) affect clinical outcomes in patients with severe TBI, hypothesizing that higher LLs would correlate with worse outcomes. : This is a level 1 single-center, retrospective study of patients with severe TBI between 1 January 2020 and 31 December 2023, inclusive.

Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation.

Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation.

Plexins: Navigating through the Neural Regulation and Brain Pathology.

Plexins are a family of transmembrane receptors known for their diverse roles in neural development, axon guidance, neuronal migration, synaptogenesis, and circuit formation. Semaphorins are a class of secreted and membrane proteins that act as primary ligands for plexin receptors. Semaphorins play a crucial role in central nervous system (CNS) development by regulating processes such as axonal growth, neuronal positioning, and synaptic connectivity.

A comprehensive review of multi-level inverters, modulation, and control for grid-interfaced solar PV systems.

With the significant development in photovoltaic (PV) systems, focus has been placed on inexpensive, efficient, and innovative power converter solutions, leading to a high diversity within power converters and new system configurations for grid-connected PV (GCPV) systems. During the last decade, multilevel inverter (MLI) designs have gained popularity in GCPV applications. This article provides a wide-ranging investigation of the common MLI topology in contrast to other existing MLI topologies for PV applications.

Evaluating a midwifery leadership programme: a process evaluation study.

Background: Despite global support for midwifery leadership investment, there is a notable lack of scientific evaluations of leadership programmes worldwide for midwives. The Government of India's Midwifery Initiative launched the Midwifery Leadership Programme to enhance the leadership capacity of state-level midwifery leaders.

Aim: To evaluate the Midwifery Leadership Programme in India using implementation science as a framework.

Enigma of Sustainable CO Conversion to Renewable Fuels and Chemicals Through Photocatalysis, Electrocatalysis, and Photoelectrocatalysis: Design Strategies and Atomic Level Insights.

Growing global population, escalating energy consumption, and climate change threaten future energy security. Fossil fuel combustion, primarily coal, oil, and natural gas, exacerbates the greenhouse effect driving global warming through CO emissions. To address such issues, research is focused on converting CO into valuable fuels and chemicals, which aims to reduce noxious CO and simultaneously bridge the gap between energy demands and sustainable supply.

Psychometric validation of type 2 Diabetes Distress Assessment System in an Indian type 2 diabetes population.

Diabetes distress (DD) significantly burdens and negatively impacts self-management and health outcomes in patients with type 2 diabetes (T2D). Early detection and management of DD are crucial for effective T2D management. The Diabetes Distress Assessment System (T2-DDAS) is a recently validated tool for measuring DD, but its psychometric properties in non-Western populations, such as India, have not been evaluated.

Horticultural additives influence peat biogeochemistry and increase short-term CO production from peat.

Aims: Peat is used as a major ingredient of growing media in horticulture. Peat extracted from bogs can be acidic and low in nutrient availability and is therefore mixed with liming agents, nutrients, surfactants, perlite and so on. This study aims to estimate the rates at which raw peat and the modified peat ('growing media') decompose to release carbon dioxide (CO), to estimate the release of carbon (C) from liming agents and to estimate how peat biogeochemistry is changed.

Innovative approaches to cationic and anionic (catanionic) amphiphiles self-assemblies: Synthesis, properties, and industrial applications.

Meeting the contemporary demand for the development of functional, biocompatible, and environment friendly self-assembled structures using efficient, cost-effective, and energy-saving methods, the field of colloids has witnessed a surge in interest. Research into cationic and anionic (catanionic) surfactant combinations has gained momentum due to their distinct advantages and synergistic properties in this context. Catanionic self-assemblies have emerged as promising contenders for addressing these requirements.

Development of a Self-Deploying Extra-Aortic Compression Device for Medium-Term Hemodynamic Stabilization: A Feasibility Study.

Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mechanical assistive devices, such as intra-aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short-term use due to risks associated with prolonged blood contact.

Women's experiences of giving birth in healthcare facilities in India -A systematic literature review of qualitative research.

Background: Childbirth in healthcare facilities has increased in South-East Asia and the focus on quality of childbirth care has increased in the region. Without a deeper understanding of women's experience of giving birth in healthcare facilities, the quality of care cannot be improved. The aim of this study was to synthesise available qualitative research from India that explores women's experiences of giving birth in healthcare facilities.

COVID-19 vaccination and neurological complications: A cross-sectional observational study from a tertiary care centre of North India.

Vaccine hesitancy, anti-Vax campaigners and misinformation hound the administration of vaccines. Our study, conducted at Malwa region of the Punjab, India, was systematically carried out to look for adverse neurological effects after COVID-19 vaccination, given to 1000 people (>18 years and <60 years) who had received either single or multiple doses. No major neurological complications were found; the only side-effect was a transitory headache in 15% of the participants.

Exploring Tractography: An Analysis of Brain Connectivity Patterns in Men.

Introduction:  White matter tracts that connect different parts of the brain comprise the structural connectome, which is essential to its operation. Assessing behavioral changes and brain health requires an understanding of these tracts. Diffusion tensor imaging (DTI), in particular, allows for the thorough viewing and characterization of these routes in tractography.

Pyrophosphate-free glycolysis in Clostridium thermocellum increases both thermodynamic driving force and ethanol titers.

Background: Clostridium thermocellum is a promising candidate for production of cellulosic biofuels, however, its final product titer is too low for commercial application, and this may be due to thermodynamic limitations in glycolysis. Previous studies in this organism have revealed a metabolic bottleneck at the phosphofructokinase (PFK) reaction in glycolysis. In the wild-type organism, this reaction uses pyrophosphate (PP) as an energy cofactor, which is thermodynamically less favorable compared to reactions that use ATP as a cofactor.

Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study.

Introduction: Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.

Methods And Analysis: We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India.

Thermal treatment and densification of manure and biomass blends to produce stabilized soil amendments.

Land application of dairy manure is the most common practice for disposal of this waste. Agricultural fields surrounding concentrated animal feeding operations (CAFOs) often have high levels of N and P because of manure over-application. However, its low bulk density limits the amount of manure that can be profitably transported for use as fuel or fertilizer.

Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.

Clinical and genetic studies strongly support a significant connection between nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD) and identify ASCVD as the primary cause of death in NAFLD patients. Understanding the molecular factors and mechanisms regulating these diseases is critical for developing novel therapies that target them simultaneously. Our preliminary immunoblotting experiments demonstrated elevated expression of nidogen 2 (NID2), a basement membrane glycoprotein, in human atherosclerotic vascular tissues and murine steatotic livers.