Onion peel derived carbon nanoparticles incorporated polysulfone membranes: enhanced dye removal from water.

The ongoing discharge of hazardous dyes from industrial processes has intensified global water pollution, posing serious threats to aquatic ecosystems and human health. Addressing this challenge, our study explores the potential of bio-based carbon nanomaterials (CNM), synthesized from onion peel biowaste and designated as ON11, as effective agents in dye removal. These CNMs were incorporated into a mixed matrix membrane (MMM), using polysulfone (PSU) as the membrane substrate, to enhance dye adsorption.

Oxygen reduction kinetics of high performance BaCoFeMYO (M = Mg, Zr) positrode for protonic ceramic fuel cells.

Protonic ceramic fuel cells (PCFCs) should exhibit high performance at intermediate temperatures in the range of 400-600 °C. To reduce the operating temperature, more active air electrodes (positrodes) are needed. In the present work, BaCoFeMgYO (BCFMY) is investigated as a positrode material for application in PCFCs as well as solid oxide fuel cells (SOFCs).

Investigating potential biomarkers and therapeutic targets for patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) through the utilization of cytokine profiling.

Objectives: Examining cytokine profile complexities in chronic autoimmune disorders holds significant clinical importance. In order to address the similarities and differences related to SLE and RA, it was necessary to evaluate their cytokine chemokine profiles. Such analyses would give pointers towards differences, leading thereby to explore the potential of cytokines/chemokines as biomarkers.

Development of coumarin-inspired bifunctional hybrids as a new class of anti-Alzheimer's agents with potent efficacy.

Considering the multifactorial and complex nature of Alzheimer's disease and the requirement of an optimum multifunctional anti-Alzheimer's agent, a series of triazole tethered coumarin-eugenol hybrid molecules was designed as potential multifunctional anti-Alzheimer's agents using donepezil and a template. The designed hybrid molecules were synthesized a click chemistry approach and preliminarily screened for cholinesterase and Aβ aggregation inhibition. Among them, AS15 emerged as a selective inhibitor of AChE (IC = 0.

Survival and toxicity outcomes of hypofractionated conformal radiotherapy compared to conventionally fractionated radiotherapy in the treatment of diffuse intrinsic pontine gliomas.

Introduction: Diffuse intrinsic pontine gliomas are associated with dismal survival outcomes. Conventional fractionation radiation to a dose of 60 Gy is the standard of treatment. This retrospective review aims to compare survival and toxicity outcomes of patients treated with conventional fractionation (CF) and hypofractionation (HF) radiotherapy.

Eco-reliable operation based on clean environmental condition for the grid-connected renewable energy hubs with heat pump and hydrogen, thermal and compressed air storage systems.

Energy hubs, with their diverse regeneration and storage sources, can engage concurrently in energy transfer and storage. It is anticipated that managing the energy of these hubs within energy networks could enhance economic, environmental, and technical metrics. This article explains how electrical and thermal network hubs manage their energy consumption in the context of the multi-criteria objectives of efficiency, sustainability, reliability of the network operator, and operation.

Optimum radiation dose for palliation in head and neck squamous cell carcinoma (OpRAH) - A phase 3 randomized controlled trial.

Purpose: Radiotherapy is frequently employed for palliative treatment in locally advanced head and neck squamous cell carcinoma (HNSCC) but radiation dose fractionation regimens are not well-defined. We designed this phase 3 randomized controlled trial to compare two weekly hypo fractionated regimes and study the effect on progression-free survival (PFS) in this subset of patients.

Materials And Methods: Non-metastatic locally advanced HNSCC patients (n = 305) who were not suitable for curative treatment were randomized to Arm A (20 Gy/5#/5 days) and Arm B (30 Gy/5#/5 days).

Indian Rheumatology Association guidelines for the management of ANCA associated vasculitis.

Background: The ACR in 2021 and the EULAR in 2022 published recommendations for management of ANCA-associated vasculitis. Given the differences in the demographic, clinical profiles, and the socio-economic realities between various countries, there is a need for development of guidelines for the management of AAV for less economically developed regions of the world.

Methods: These guidelines were made following the GRADE methodology.

Sensitivity Chronicles in Molecular Properties: Unraveling the Nexus of Dual-Beam Z-Scan and Time-Resolved Thermal Lens Spectroscopy.

Ultrasensitive thermal lens (TL) spectroscopy, where the interplay between conduction and convection is crucial, provides profound insights into molecular behavior. This work focuses on the critical role of molecular convection by using the dual-beam z-scan method and time-resolved TL spectroscopy. We specifically investigated the correlation between the detection iris and the spot size of the pump beam.

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.

Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly transcribed RNA molecule hybridizes with the DNA template strand. This study investigated the role of RAD52, a known DNA repair factor, in preventing collisions by directing R-loop formation and resolution.

Dynamics of KNi(SO) governed by proximity to a 3D spin liquid model.

Quantum spin liquids (QSLs) have become a key area of research in magnetism due to their remarkable properties, such as long-range entanglement, fractional excitations, and topologically protected phenomena. Recently, the search for QSLs has expanded into the three-dimensional world, despite the suppression of quantum fluctuations due to high dimensionality. A new candidate material, KNi(SO), belongs to the langbeinite family and consists of two interconnected trillium lattices.

Clinical and toxicity outcomes with 3D based-HDR surface mold brachytherapy in skin cancer.

Introduction: Surface mold brachytherapy (SMBT) is an established treatment modality in skin cancer, especially in accessible areas, and has shown comparable outcomes to surgery. We have presented our results for the skin tumor treatment with SMBT treated with high-dose-rate (HDR) brachytherapy in terms of clinical outcomes and toxicity at our institute.

Materials And Methods: In this retrospective analysis, 15 patients with skin cancer were treated with customized tube-based SMBT at our institute between January 2019 and July 2021.

Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure-Activity Relationships.

Breast cancer is the most common cancer among women. Currently, it poses a significant threat to the healthcare system due to the emerging resistance and toxicity of available drug candidates in clinical practice, thus generating an urgent need for the development of new potent and safer anti-breast cancer drug candidates. Coumarin (chromone-2-one) is an elite ring system widely distributed among natural products and possesses a broad range of pharmacological properties.

Efficient cationic dye removal from water through skin-derived carbon nanospheres: a rapid and sustainable approach.

The present study investigates the potential of skin-derived carbon nanospheres (CNSs) as an efficient adsorbent for the rapid removal of cationic dyes from aqueous solutions. The CNSs were synthesized through a facile, cost-effective, catalyst-free and environmentally friendly process, utilizing skin waste as a precursor. This is the first reported study on the synthesis of mesoporous carbon nanospheres from skin.

ANCA-Associated Vasculitis with Systemic Thrombotic Microangiopathy: A Review of Literature.

Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) rarely coexist with systemic thrombotic microangiopathy (TMA).The TMA can be in the form of either hemolytic uremic syndrome (HUS) or thrombotic thrombocytopenic purpura (TTP). This review explores the clinical characteristics, histopathological findings, treatment options, and outcomes in patients presenting as AAV with coexisting HUS/TTP.

The modern landscape of radiotherapy in thyroid malignancies.

Thyroid carcinoma is the most common malignancy of the endocrine system and accounts for nearly 1.5% of all new cancer cases in India. The incidence of thyroid cancers is on the rise secondary to multiple factors including the widespread use of radiological imaging.