[Outbreak of enteroviral infection in Vitebsk during pollution of water supply by enteroviruses].

The conducted virologic, serological and molecular-and-biological investigations showed that virus Coxsakie B4, isolated from cerebrospinal fluid and rhinopharyngeal lavages of patients, was the main etiological agent, which caused mainly an outbreak of enterovirus infection in the city of Vitebsk in 2001. Coxsakie B4 viruses were found in 30% of samples by using the cultural method and in 76.9% of samples--by polymerase chain reaction (PCR) while carrying out the sanitary-and-virologic investigations in drinking water, including in infection foci.

[Experience in the use of chemical compounds for the primary identification and differentiation of enteroviruses].

Data on the usage of chemical inhibitors nifan and belvtazid, which possess a selective and antienteroviral effect, in the primary identification of enteroviruses and their differentiation into polio- and non-poliomyelytic ones isolated from human clinical materials or the environment by using the cell culture are presented in the article. The method is recommended for the practical use by the virology service in the diagnostics of enteroviral infections and in the identification of cytopathic agents isolated from the enviroment.

Viral water contamination as the cause of aseptic meningitis outbreak in Belarus.

In the recent years Echovirus-30 associated outbreaks have taken place in different European countries. Aseptic meningitis caused by Echovirus-30 was the main diagnosis of a large outbreak in Belarus in Summer-Autumn, 1997, involving 460 patients. Echovirus-30 was detected in cerebrospinal fluid of the patients with aseptic meningitis.

[Water-borne outbreak of serous meningitis caused by Echovirus-30 in Belarus].

In recent years outbreak of enterovirus infections caused by Echovirus-30 were rather frequently registered in different European countries. A major outbreak caused by this virus took place during the summer-autumn period of 1997 in the city of Gomel, Belarus. Sanitary epidemiological and molecular epidemiological studies made it possible to determine that the outbreak was water-borne.

[Active aluminum oxide--a new adsorbent for concentrating intestinal viruses from water].

Concentrating properties of a new adsorbent, active aluminum oxide, towards poliomyelitis virus type III and simian rotavirus are studied using virus contamination of sewage and drinking water. Optimal concentrations of the adsorbent for effective adsorption of both rota- and polioviruses are established (1.5 and 1 g/liter, respectively) at pH typical of sewage and drinking water (7.

[Use of rapid methods in detection of enteroviruses].

Indirect immunofluorescence (IIF) and RT-PCR were used for rapid diagnosis of enterovirus infection during an outbreak of aseptic meningitis in Gomel. IgM to enterovirus were detected in 93.6% sera by IIF and in 71.

[Mechanism of virus-induced immunopathology. I. The reactivity of immunocompetent cells in acute herpetic infection in an experiment].

The state of general and specific responsiveness of thymocytes and splenocytes in non-inbred white mice has been studied in the reaction of lymphocyte blast transformation under the influence of phytohemagglutinin (PHA) and herpes simplex virus. Experimental herpetic encephalitis has been shown to give rise to the development of pronounced immunosuppression, which is confirmed by a considerable decrease (P less than 0.05) in the levels of the PHA- and virus-induced transformation of thymocytes and splenocytes in infected mice in comparison with the similar transformation characteristics of intact lymphocytes.