Ameliorative effects of Tricholepis glaberrima in experimentally induced hepatic damage in rats: modulation of cytokines functions.

Ethnopharmacological Relevance: Tricholepis glaberrima belonging to family Asteraceae is popularly known as "Brahmadandi" in Indian system of medicine and is claimed to be effective in the treatment of various ailments such as neurological disorders, hepatic disorders, sexual dysfunction, skin disease etc. The present study was undertaken to investigate the possible role of Tricholepis glaberrima in rifampicin and Bacillus Calmette-Guerin/lipopolysaccharides (BCG/LPS) induced hepatotoxicity in rats and its possible mechanism of actions.

Materials And Methods: Hepatotoxicity was induced in rats by administration of rifampicin for 30 days and in another experiment BCG on day 1 and LPS on day 11.