Publications by authors named "Shari L Simone"

Article Synopsis
  • This study focused on understanding how common diagnostic uncertainty is when critically ill children are admitted to Pediatric Intensive Care Units (PICUs) and what factors contribute to it.
  • Researchers reviewed medical records from 882 pediatric patients across four hospitals to assess the presence of diagnostic uncertainty at admission and how it changed by the time of discharge.
  • Key findings indicated that 25.9% of patients showed diagnostic uncertainty upon PICU admission, with significant factors being the time of admission, illness severity, atypical symptoms, and discrepancies in diagnoses between different healthcare providers.
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Objectives: Effective interventions to prevent diagnostic error among critically ill children should be informed by diagnostic error prevalence and etiologies. We aimed to determine the prevalence and characteristics of diagnostic errors and identify factors associated with error in patients admitted to the PICU.

Design: Multicenter retrospective cohort study using structured medical record review by trained clinicians using the Revised Safer Dx instrument to identify diagnostic error (defined as missed opportunities in diagnosis).

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Objective: Care of critically ill children includes sedation but current therapies are suboptimal. To describe dexmedetomidine use in children supported on mechanical ventilation for acute respiratory failure.

Design: Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial.

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