Publications by authors named "Shareefa Thekkan"
Article Synopsis
- Lysosomal storage disorders (LSDs) and Alzheimer's disease (AD) show overlapping features, particularly with lysosomal dysfunction potentially playing a role in AD pathogenesis.
- Research found that lysosomal ionic regulation is disrupted in blood-derived monocytes from AD patients, which correlates with known AD pathology markers.
- A machine learning model developed from this data suggests a promising noninvasive biomarker platform for diagnosing AD and emphasizes the need to explore therapies aimed at restoring lysosome function.
Several independent determinations of the p values of -resveratrol in water have led to conflicting results. Singular value decomposition analysis of UV absorption spectra of -resveratrol (Resv) in N-outgased aqueous solutions buffered to pH values in the 7.0-13.
View Article and Find Full Text PDFPhagocytes destroy pathogens by trapping them in a transient organelle called the phagosome, where they are bombarded with reactive oxygen species (ROS) and reactive nitrogen species (RNS). Imaging reactive species within the phagosome would directly reveal the chemical dynamics underlying pathogen destruction. Here we introduce a fluorescent, DNA-based combination reporter, cHOClate, which simultaneously images hypochlorous acid (HOCl) and pH quantitatively.
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