Publications by authors named "Sharan A"

Background: The increasing prevalence of obesity has raised concerns about its impact on surgical outcomes and healthcare costs. This study evaluates the influence of Body Mass Index (BMI) on intraoperative costs and operative times during open Transforaminal Lumbar Interbody Fusion (TLIF) procedures using a Time-Driven Activity-Based Costing (TDABC) approach.

Methods: A retrospective analysis was conducted on 279 patients who underwent TLIF between 2019 and 2022.

View Article and Find Full Text PDF

Introduction: Many studies have evaluated the effect of preoperative disability status on functional outcomes following spine surgery. However, no research has compared the "value" (outcomes per dollar spent) of surgery for patients with different levels of diagnosis-specific disability.

Methods: We retrospectively reviewed 429 patients who underwent neurosurgical anterior cervical discectomy and fusion.

View Article and Find Full Text PDF

Introduction And Importance: Bladder cancer is predominantly characterized by urothelial carcinomas, but small cell neuroendocrine carcinomas (SCNEC) represent a rare and aggressive subset.

Case Presentation: A 50-year-old male presented with painless hematuria and voiding difficulties. Ultrasonography revealed a 3.

View Article and Find Full Text PDF

Background: Dentinal hypersensitivity (DH) is a prevalent condition characterized by sharp, transient pain arising from exposed dentine in response to various stimuli. It is common among patients with gingival recession, tooth abrasion, and erosion.

Materials And Methods: A prospective experimental study was conducted in the Department of Periodontology at the Chhattisgarh Dental College and Research Institute.

View Article and Find Full Text PDF

Malakoplakia, a rare acquired histiocytic inflammatory disease. It is an incidental finding on histopathology examination, as it does not have definite clinical manifestations. It typically affects the genitourinary tract but can also involve various anatomical sites.

View Article and Find Full Text PDF

The archaeal class is widely and abundantly distributed in anoxic habitats. Metagenomic studies have suggested that they are mixotrophic, capable of CO fixation and heterotrophic growth, and involved in acetogenesis and lignin degradation. We analyzed 35 metagenome-assembled genomes (MAGs), including the first complete circularized MAG (cMAG) of the Bathy-6 subgroup, from the metagenomes of three full-scale pulp and paper mill anaerobic digesters and three laboratory methanogenic enrichment cultures maintained on pre-treated poplar.

View Article and Find Full Text PDF

Background And Objectives: A few studies have compared the value (outcomes per dollar spent) provided by transforaminal endoscopic discectomy (TED) vs microdiscectomy (MD) for lumbar disc herniations. Here, we attempt to address this gap using a novel Operative Value Index (OVI), which combines a procedure-specific patient-reported outcome with intraoperative cost data based on time-driven activity-based costing.

Methods: MD (n = 95) and TED (n = 23) performed by neurosurgeons at our institution from 2017 to 2022 were retrospectively identified.

View Article and Find Full Text PDF
Article Synopsis
  • Total disc replacement (TDR) is an alternative to anterior cervical discectomy and fusion (ACDF), and this study compares their costs as we shift towards value-based healthcare.
  • Using time-driven activity-based costing (TDABC), researchers reviewed the costs of both procedures, analyzing direct and indirect costs through observation and data collection from various departments.
  • The results showed that TDRs had significantly higher total intraoperative costs ($12,026) compared to ACDFs ($6,776), with the majority of the cost difference attributed to more expensive supply items, particularly implants.
View Article and Find Full Text PDF

We present a dataset of six metagenomes and 323 metagenome assembled genomes (MAGs) describing the microbial community of anaerobic digesters at three Canadian pulp and paper mills. Our objective was to assess the coding potential of the microbial community and obtain draft genomes of key organisms in the digesters.

View Article and Find Full Text PDF
Article Synopsis
  • Neuropathic pain (NP) is a challenging condition that can occur after spinal cord injury (SCI), and this study investigates the brain area called the periaqueductal gray (PAG) and how it relates to NP development using resting-state functional MRI (rsfMRI).
  • The research involved 20 participants: 10 SCI patients (with and without NP) and 10 healthy controls, examining differences in functional connectivity (FC) between the PAG and other brain regions.
  • Findings revealed decreased FC in SCI patients with NP compared to healthy controls and increased FC in other areas when compared to SCI patients without NP, suggesting significant brain connectivity alterations linked to neuropathic pain after spinal cord injury.
View Article and Find Full Text PDF
Article Synopsis
  • Elective lumbar fusions are often criticized for being used improperly, prompting a study using a new Operative Value Index (OVI) to evaluate the cost-effectiveness of evidence-based lumbar fusions.
  • A retrospective analysis of 294 patients found that a majority (92.9%) underwent evidence-based surgeries, with OVI measuring patient improvement per dollar spent showing significantly better outcomes for these procedures compared to non-evidence-based ones.
  • The results indicate that adhering to evidence-based guidelines leads to greater patient improvement (2% per $1000 spent) and highlights the potential for systematic improvements in lumbar fusion practices.
View Article and Find Full Text PDF

Introduction: In high-frequency spinal cord stimulation anatomic placement targeting of the T9-10 disc space is based on "empiric" results that are best replicated with coverage broadly from T8 to T10. This study contains the largest cohort of patients evaluating low thoracic morphology and seeks to address the lack of MRI morphological analysis in literature.

Methods: This study was a retrospective review of a database of 101 consecutive patients undergoing permanent implant of thoracic SCS for chronic pain.

View Article and Find Full Text PDF

Background And Objectives: Endoscopic lumbar diskectomy (ED) is a minimally invasive option for addressing lumbar disk herniations. With the introduction of value-based care systems, assessing the true cost of certain procedures is critical when creating reimbursement models and comparing procedures. Here, we compared the costs of performing a microdiskectomy (MD) and ED using time-driven activity-based costing.

View Article and Find Full Text PDF

Groundwater salinity is a critical factor affecting water quality and ecosystem health, with implications for various sectors including agriculture, industry, and public health. Hence, the reliability and accuracy of groundwater salinity predictive models are paramount for effective decision-making in managing groundwater resources. This pioneering study presents the validation of a predictive model aimed at forecasting groundwater salinity levels using three different validation methods and various data partitioning strategies.

View Article and Find Full Text PDF

Introduction: Adoption of robotic techniques is increasing for neurosurgical applications. Common cranial applications include stereoelectroencephalography (sEEG) and deep brain stimulation (DBS). For surgeons to implement robotic techniques in these procedures, realistic learning curves must be anticipated for surgeons to overcome the challenges of integrating new techniques into surgical workflow.

View Article and Find Full Text PDF

In this work, a relatively new class of materials, rare earth (RE) based high entropy oxides (HEO) are discussed in terms of the evolution of the oxygen vacant sites (O) content in their structure as the composition changes from binary to HEO using both experimental and computational tools; the composition of HEO under focus is the CeLaPrSmGdO due to the importance of ceria-related (fluorite) materials to catalysis. To unveil key features of quinary HEO structure, ceria-based binary CePrO and CeLaO compositions as well as SiO, the latter as representative nonreducible oxide, were used and compared as supports for Ru (6 wt % loading). The role of the O in the HEO is highlighted for the ammonia production with particular emphasis on the N dissociation step (N → N) over a HEO; the latter step is considered the rate controlling one in the ammonia production.

View Article and Find Full Text PDF

Study Design: The present study is a single-center, retrospective cohort study of patients undergoing neurosurgical anterior cervical discectomy and fusion (ACDF).

Objective: Our objective was to use time-driven activity-based costing (TDABC) methodology to determine whether surgeons' case volume influenced the true intraoperative costs of ACDFs performed at our institution.

Summary Of Background Data: Successful participation in emerging reimbursement models, such as bundled payments, requires an understanding of true intraoperative costs, as well as the modifiable drivers of those costs.

View Article and Find Full Text PDF

Background: Positive correlations between low- and high-frequency spectra from stereotactic electroencephalogram (SEEG) recordings have been implicated in pathological brain activity interictally and have been used for ictal detection in both focal and network models.

Objective: We evaluated SEEG signals in patients who ultimately underwent temporal lobectomy to evaluate their utility in seizure localization and prediction of seizure freedom post-resection.

Methods: We retrospectively analyzed cross-frequency correlations between beta and high gamma (HG) interictal SEEG signals from 22 patients.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to analyze and compare the marginal intraoperative costs of three methods for pedicle screw placement during transforaminal lumbar interbody fusions (TLIFs), specifically looking at robot-assisted TLIF, intraoperative navigation TLIF, and freehand TLIF.
  • Data were collected from 2020 to 2022, involving 20 robot-assisted, 59 navigation, and 233 freehand procedures. Cost analysis included direct and indirect expenses, using software to extract resource usage from electronic medical records.
  • Results indicated that robot-assisted TLIF was significantly more expensive ($24,838) than both intraoperative navigation TLIF ($15,991) and freehand TLIF ($
View Article and Find Full Text PDF
Article Synopsis
  • Spine surgeons need to understand cost variations in anterior cervical discectomy and fusion (ACDF), especially how BMI affects costs and operating room (OR) times.
  • A study analyzed 959 ACDF patients from 2017 to 2022 using time-driven activity-based costing, finding that while BMI did not significantly impact total surgery costs, it increased the time spent in the OR.
  • The research concluded that time-driven costing can help clarify true surgical costs, highlighting that higher BMI led to longer preparatory times in the OR, even though it didn't raise the total procedure cost.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the functional connectivity (FC) of the brain in spinal cord injury (SCI) patients, focusing on those experiencing neuropathic pain (NP) compared to those without pain.
  • A total of 10 SCI patients (7 with NP and 3 without) were evaluated, alongside 10 neurologically healthy controls, using resting-state functional magnetic resonance imaging.
  • Results show that specific thalamic nuclei in SCI patients with moderate-to-severe NP demonstrated altered connectivity patterns, indicating a potential disruption in pain processing pathways following a spinal cord injury.
View Article and Find Full Text PDF
Article Synopsis
  • Activity trackers and wearables can accurately measure physical activity and vital signs, greatly benefiting healthcare, especially for spine patients.
  • Various sensors, like accelerometers and GPS, allow detailed tracking of movement and location, providing valuable mobility assessments.
  • Existing mobile applications aim to improve patient care but need to better utilize sensor data for a more precise assessment of spine patients' functional status and outcomes.
View Article and Find Full Text PDF

Small island countries like Vanuatu are facing the brunt of climate change, sea level rise (SLR), tropical cyclones, and limited or declining access to freshwater. The Tagabe coastal aquifer in Port Vila (the capital of Vanuatu) shows the presence of salinity, indicating saltwater intrusion (SWI). This study aims to develop and evaluate effective SWI management strategies for Tagabe coastal aquifer.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how spinal cord injury (SCI) affects the thalamus in children using diffusion tensor imaging (DTI) to analyze microstructural changes.
  • Researchers assessed 18 pediatric patients with chronic SCI, categorizing them based on the severity of their injury according to the American Spinal Injury Association Impairment Scale (AIS).
  • Results showed notable differences in DTI metrics (FA, AD, RD, MD) across different AIS groups, indicating varying levels of microstructural alterations in specific thalamic nuclei related to the severity of the injury.
View Article and Find Full Text PDF

Patients with breast cancer (BC) typically undergo multimodal treatment over an extended period and deal with a wide range of symptoms that severely impair their overall quality of life (QoL) and prognosis. Concern about the health-related QoL of persons diagnosed with cancer as well as the calibre of care they receive is increasing every day. This study aims to assess the impact of yoga on the QoL of patients with BC.

View Article and Find Full Text PDF