Publications by authors named "Sharada Krishnagiri"
Article Synopsis
- * Researchers used light to activate specially designed nanoparticles that can increase the permeability of the BSCB, allowing normally restricted peptides to enter the spinal cord without harming the surrounding cells or affecting movement.
- * The method effectively delivered the peptide bombesin into the spinal cord, leading to a quick rise in itching behavior in mice, showcasing potential for non-invasive therapies targeting spinal cord conditions.
Ephrin-B-EphB signaling can promote pain through ligand-receptor interactions between peripheral cells, like immune cells expressing ephrin-Bs, and EphB receptors expressed by DRG neurons. Previous studies have shown increased ephrin-B2 expression in peripheral tissues like synovium of rheumatoid and osteoarthritis patients, indicating the clinical significance of this signaling. The primary goal of this study was to understand how ephrin-B2 acts on mouse and human DRG neurons, which express EphB receptors, to promote pain and nociceptor plasticity.
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