Publications by authors named "Shara Jaramillo-Garrido"
Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles.
Tatiana Z Cuellar-Gaviria Maria Angelica Rincon-Benavides Hatice Nur Halipci Topsakal Ana Isabel Salazar-Puerta Shara Jaramillo-Garrido
J Control Release
December 2024
Article Synopsis
- Antibiotic-resistant bacteria, like Staphylococcus aureus, pose a serious health threat, necessitating new treatment strategies against infections.
- The study explored the use of tissue-nanotransfection (TNT) to deliver a gene (CAMP) that enhances the production of an antimicrobial peptide (LL-37) in mice with infected wounds.
- Results showed that TNT treatment effectively reduced bacterial load, improved wound healing indicators, and increased immune response, highlighting its potential as a novel method for treating difficult infections.