Cord blood serum affects T cells ability to produce and respond to IL-2.

The current literature suggests that cord blood (CB) cells are functionally immature. We previously reported that CB sera inhibit T cell proliferation and suggested that the microenvironment in which CB T cells reside may be, in part, responsible for their reduced function. In this study we have tried to explain some of the actions of the CB sera on peripheral blood mononuclear cells (PBMC).

The effect of cord blood sera on CD69 expression.

We have reported previously that cord blood (CB) sera inhibit T cell proliferation and cytokine production, and have suggested that the microenvironment that CB T cells come from may be responsible for the reduced function of CB T cells. In the present study we analysed the effect of CB sera on the expression of CD69, the earliest activation marker, on T and natural killer (NK) cells. CD69 expression on adult NK cells was higher than on CB NK cells (p<0.