Publications by authors named "Shapkina V"

Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration of the blood vessels, including .

View Article and Find Full Text PDF

SARS-CoV-2 infection may cause such complications as post-COVID-19 syndrome, which includes chronic fatigue, myalgia, arthralgia, as well as a variety of neurological manifestations, e.g., neuropathy of small fibers, hearing and vestibular dysfunction, and cognitive impairment.

View Article and Find Full Text PDF

Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains significantly understudied. This study aimed to identify the clinical and histological correlates of small fiber neuropathy in sarcoidosis patients.

View Article and Find Full Text PDF

Unlabelled: Neural network analysis of digital copies of histological micropreparations is one of the methods used to standardize quantitative continuous data. PD-L1 (22C3) biomarker expression in metastatic non-small cell lung carcinomas without mutations in the EGFR, ALK, and ROS1 genes serves as an indication for the use of pembrolizumab for the first-line therapy.

Objective: To quantify PD-L1 biomarker expression in non-small cell lung carcinomas using the neural network analysis of digital copies of histological micropreparations.

View Article and Find Full Text PDF

Aim: to assess types of immune response in patients with advanced suppurative peritonitis and course of disease.

Material And Methods: We examined 79 patients with acute surgical abdominal diseases and injuries complicated by advanced suppurative peritonitis. Blood immunological parameters were estimated using flowing cytometry and enzyme immunoassay.

View Article and Find Full Text PDF

Results of the treatment of generalized purulent peritonitis in 30 patients are presented. Based on the analysis of the performance of integrated assessment scales severity of the condition, the dynamics of change of bacterial contamination and microbiological landscape, and analysis of morbidity and mortality proved the effectiveness of intraperitoneal administration of the solution of dioxidin in patients with generalized purulent peritonitis.

View Article and Find Full Text PDF