Notch1 promotes resistance to cisplatin by up-regulating Ecto-5'-nucleotidase (CD73) in triple-negative breast cancer cells.

Triple-negative breast cancer (TNBC) is an aggressive molecular subtype that due to lack of druggable targets is treated with chemotherapy as standard of care. However, TNBC is prone to chemoresistance and associates with poor survival. The aim of this study was to explore the molecular mechanisms of chemoresistance in TNBC.

A Highly Efficient Bismuth Nitrate/Keto-ABNO Catalyst System for Aerobic Oxidation of Alcohols to Carbonyl Compounds under Mild Conditions.

An efficient and practical catalytic system for the oxidation of alcohols to aldehydes/ketones using catalytic amounts of Bi(NO) and Keto-ABNO (9-azabicyclo [3.3.1]nonan-3-one -oxyl) with air as the environmentally benign oxidant was developed.

Co-embedding oxygen vacancy and copper particles into titanium-based oxides (TiO, BaTiO, and SrTiO) nanoassembly for enhanced CO photoreduction through surface/interface synergy.

Photocatalytic CO reduction into valuable fuel and chemical production has been regarded as a prospective strategy for tackling with the issues of the increasing of greenhouse gases and shortage of sustainable energy. A composite photocatalysis system employing a semiconductor enriched with oxygen vacancy and coupled with metallic cocatalyst can facilitate charge separation and transfer electrons. In this work, mesoporous TiO and titanium-based perovskite oxides (BaTiO and SrTiO) nanoparticle assembly incorporated with abundant oxygen vacancy and copper particles have been successfully synthesized for CO photoreduction.

GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.

Despite remarkable advancements in our understanding of breast cancer, it remains the leading cause of cancer deaths in women. Distant recurrence and metastasis is the main reason for death due to breast cancer. It is well recognized that the GATA binding protein 3 (GATA3), a transcription factor, is a tumor suppressor in breast cancer.

Preparation of highly active and hydrothermally stable nickel catalysts.

The 60%Ni/AlSiO catalysts were prepared by the co-precipitation method, in which AlSiO were the composite supports with different mass ratios of Al2O3 and SiO2. It was found that the catalyst 60%Ni/AlSiO-4 with the Al2O3/SiO2 mass ratio of 4 in the support exhibited the high hydrothermal stability. The addition of proper amount of SiO2 inhibited the hydration of Al2O3 and prevented the growth of supported nickel particles during the hydrothermal treatment.