Design, Synthesis, and Biological Evaluation of Derivatives as Novel Brain-Penetrant and Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment.

A series of structurally novel GluN2B NMDAR antagonists were designed, synthesized, and biologically evaluated as anti-stroke therapeutics by optimizing the chemical structure of , the active ingredient of traditional Chinese medicine identified via screening. The systematic structure-activity relationship study led to the discovery of with promising NMDAR-GluN2B binding affinity and antagonistic activity. Of the two enantiomers, exhibited significant inhibition (IC = 74.

Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.

Mediator subunit mediator 1 (MED1) mediates ligand-dependent binding of the mediator coactivator complex to various nuclear receptors and plays a critical role in embryonic development, lipid and glucose metabolism, liver regeneration, and tumorigenesis. However, the precise role of MED1 in the development of liver fibrosis has been unclear. Here, we showed that MED1 expression was increased in livers from nonalcoholic steatohepatitis (NASH) patients and mice and positively correlated with transforming growth factor β (TGF-β) signaling and profibrotic factors.

Novel Fluorescent Probe toward Fe Based on Rhodamine 6G Derivatives and Its Bioimaging in Adult Mice, , and Plant Tissues.

A new fluorescent probe based on the rhodamine 6G platforms has been designed, synthesized, and characterized, which could recognize Fe effectively in HEPES buffer (10 mM, pH = 7.4)/CHCN (2:3, v/v). And the distinct color change and the rapid emergence of fluorescence emission at 550 nm achieved "naked eye" detection of Fe.

Long read sequencing of Toona sinensis (A. Juss) Roem: A chromosome-level reference genome for the family Meliaceae.

Chinese mahogany (Toona sinensis) is a woody plant that is widely cultivated in China and Malaysia. Toona sinensis is important economically, including as a nutritious food source, as material for traditional Chinese medicine and as a high-quality hardwood. However, the absence of a reference genome has hindered in-depth molecular and evolutionary studies of this plant.