Ester-Modified Sodium Silicate Grout Material for Moraine Stabilization: Synthesis and Freeze-Thaw Resistance.

To achieve effective consolidation of fine particles in moraine and enhance the freeze-thaw resistance of the consolidated body, this study developed a novel grouting material using sodium silicate, lipid-based curing agents, and acidic catalysts. The gelation time and rheological properties of this material were tested. The freeze-thaw resistance was studied through changes in uniaxial compressive strength (UCS) after freeze-thaw cycles, while the consolidation mechanism was analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).

Environmental disposal of sulphide-rich and desulfurized tailings: Thickening, rheological, mechanical, and leaching performance.

The surface disposal of sulphide-rich tailings (compared to ordinary tailings, it contains many sulphides) will cause environmental and groundwater pollution, and it is an eco-friendly method to prepare cemented paste backfill (CPB) from sulphide-rich tailings and backfill it into underground goafs. However, the thickening performance of sulphide-rich and desulfurized tailings is unclear, the sulphide-rich CPB strength cannot meet the standard. Therefore, a comprehensive study was conducted on its thickening performance through settling columns and dynamic thickening experiments, mechanics, and leaching tests were also conducted.

Microbial carbonate reservoir characteristics and their depositional effects, the IV Member of Dengying Formation, Gaoshiti-Moxi area, Sichuan Basin, Southwest China.

Previous scientific research on reservoirs of the Deng IV Member in the Gaoshiti-Moxi area, the main production area of the Anyue gas field with reserves of tens of billions of cubic metres, has focused on karst palaeogeomorphology reconstruction, the facies distribution on platform margins, and their effects on creating favourable reservoirs. However, the quality of microbial carbonate reservoirs is also closely related to their original depositional environments on both inner and marginal platforms. Therefore, this paper attempts to reveal favourable microbial carbonate reservoir characteristics and the sedimentary effects on their distribution and prediction based predominantly on a synthetic analysis of the sequence stratigraphy and depositional facies.

HO enhances the spontaneous phasic contractions of isolated human-bladder strips via activation of TRPA1 channels on sensory nerves and the release of substance P and PGE2.

Several studies have indicated that reactive oxygen species (ROS) can lead to detrusor overactivity (DO), but the underlying mechanisms are not known. Hydrogen dioxide (HO) is used commonly to investigate the effects of ROS. In present study, we investigated the effects of HO on phasic spontaneous bladder contractions (SBCs) of isolated human-bladder strips (iHBSs) and the underlying mechanisms.

Insights into the streamwater age in the headwater catchments covered by glaciers and permafrost, Central Tibetan Plateau.

Improving our understanding of streamwater age knowledge is critical for revealing the complex hydrological processes in alpine cryosphere catchments. However, few studies on water age have been conducted in alpine cryosphere catchments due to the complicated and inclement environment. In this study, the Buqu catchment, a typical alpine catchment covered by glaciers and permafrost on the central Tibetan Plateau (TP), was selected as the study area.

Inflammatory molecules facilitate the development of docetaxel-resistant prostate cancer cells in vitro and in vivo.

Numerous molecular mechanisms have been found to contribute to docetaxel-induced resistance in prostate cancer (PCa). In this study, the changes in gene expression profiles of multidrug resistant PCa cells that were established in response to docetaxel were determined using microarray analysis. In addition to alterations in the expression of multidrug resistance-associated genes, the expression levels of multiple inflammatory molecules, in particular IL-6, significantly increased in resistant cells in vitro and in vivo, which further increased with the development of drug resistance following microarray, qRT-PCR and ELISA analysis.

A global meta-analysis of the impacts of exotic plant species invasion on plant diversity and soil properties.

Plant diversity and biogeochemical cycles are rapidly changing in response to exotic plant species invasion. However, there are conflicting conclusions regarding the quantification of such changes in the soil properties and plant diversity. Moreover, the relationships between soil properties and plant diversity are unclear.

Transcutaneous electrical nerve stimulation and solifenacin succinate versus solifenacin succinate alone for treatment of overactive bladder syndrome: A double-blind randomized controlled study.

Objective: We evaluated a combination of transcutaneous electrical nerve stimulation (TENS) and solifenacin succinate versus solifenacin alone in the treatment of overactive bladder (OAB).

Methods: Ninety-seven female outpatients with OAB were screened for this double-blind randomized controlled study. Eighty-six patients who met our inclusion criteria were divided randomly into two groups.

Activation of TRPM8 channel inhibits contraction of the isolated human ureter.

Aims: The transient receptor potential melastin-8 (TRPM8) channel is a "cooling" receptor expressed in primary sensory neurons and can be activated by compounds like menthol or icilin. TRPM8 is involved in the regulation of urinary bladder sensory function and contraction, but the role of TRPM8 in the ureter, particularly in the human ureter, is poorly understood. The aim of this study is to examine the effects of TRPM8 activation on human ureter contraction.

Cell Deformation at the Air-Liquid Interface Evokes Intracellular Ca Increase and ATP Release in Cultured Rat Urothelial Cells.

Urothelial cells have been implicated in bladder mechanosensory transduction, and thus, initiation of the micturition reflex. Cell deformation caused by tension forces at an air-liquid interface (ALI) can induce an increase in intracellular Ca concentration ([Ca]) and ATP release in some epithelial cells. In this study, we aimed to examine the cellular mechanisms underlying ALI-induced [Ca] increase in cultured urothelial cells.

Age-related reductions in the excitability of phasic dorsal root ganglion neurons innervating the urinary bladder in female rats.

Previous studies have revealed an impairment in bladder sensory transduction in aged animals. To examine the contributions of electrical property changes of bladder primary afferents to this impairment, we compared the electrical properties of dorsal root ganglion (DRG) neurons innervating the bladder among young (3 months), middle-aged (12 months), and old (24 months) female rats. The DRG neurons were labeled using axonal tracing techniques.

TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.

Aims: Sensory nerve activation modulates ureteral contractility by releasing neuropeptides including CGRP and neurokinin A (NKA). TRPM3 is a recently discovered thermosensitive channel expressed in nociceptive sensory neurons, and plays a key role in heat nociception and chronic pain. The aim of this study is to examine the role of TRPM3 activation in human ureter motility.

Urinary ATP may be a biomarker for bladder outlet obstruction and its severity in patients with benign prostatic hyperplasia.

Background: Urothelial cells release ATP into the urine in response to bladder stretch. Urinary ATP concentration in benign prostatic hyperplasia (BPH) patients was higher compared with asymptomatic controls. In this study, we aimed to explore the possibility that the urinary ATP level could be a non-invasive biomarker for bladder outlet obstruction (BOO) and its severity in BPH patients.

[Characteristics and Influencing Factors of Stable Hydrogen and Oxygen Isotopes in Groundwater in the Permafrost Region of the Source Region of the Yangtze River].

We use 84 rainfall samples collected during June to September 2017 from the Dongkemadi basin, source region of the Yangtze River, China, to analyze the characteristics and influencing factors of stable isotopes in groundwater, and further discuss the groundwater recharge sources. The results showed that the range of groundwater O values in this permafrost region varied from -15.3‰ to -12.

[Chemical Characteristics and Ionic Sources of Precipitation in the Source Region of the Yangtze River].

Using 64 precipitation samples collected from June to September 2013 in the Dongkemadi Basin in the source region of the Yangtze River, the pH, conductivity, and main ionic concentration characteristics of precipitation were analyzed. The main ionic sources of precipitation and their relationships with atmospheric circulation were examined using factor analysis, correlation analysis, enrichment factor analysis, and backward trajectory analysis. The results showed that the range of precipitation pH values varied from 5.

[Characteristics of Stable Isotopes in Precipitation and Moisture Sources in the Headwaters of the Yangtze River].

Based on the stable isotopes of 73 precipitation samples continuously collected from May to October 2014 and related meteorological statistics in the Dongkemaldi Basin, the characteristics of D, O, and -excess of precipitation, as well as the correlations between O and the rainfall amount and air temperature were analyzed. The moisture sources were tracked by the HYSPLIT model to further estimate the contribution of different water vapor sources to the rainfall amount. The results showed that the range of O and D values varied from -26.

Imbalance of Th22/Treg cells causes microinflammation in uremic patients undergoing hemodialysis.

Background: Regulatory T (Treg) cells are of critical functionality in immune activation and inflammation in uremic patients undergoing hemodialysis (HD). A disruption in balance of Treg cells has potency to elicit infectious disease progression. Here, we examined possible association between ratio imbalance of Th22/Treg cells and microinflammation in uremic patients undergoing HD.

Comparisons of short-term and survival outcomes of laparoscopy-assisted versus open total gastrectomy for gastric cancer patients.

Objectives: The safety and surgical oncology of laparoscopy-assisted total gastrectomy (LATG) remain inconclusive and challenging. This study aimed to compare the short-term and long-term outcomes between LATG and open total gastrectomy (OTG) procedures.

Results: In the all-included analyses, there were 69 patients in the LATG group and 268 in the OTG group.

[Medial approach versus lateral approach in laparoscopic colorectal resection: a meta-analysis].

Objective: To compare the safety and efficacy of the medial approach(MA) and the lateral approach (LA) in the treatment of colorectal disease.

Methods: Studies published from January 1994 to April 2013 that compared MA to LA in laparoscopic colorectal resection were collected. Publications in English were mainly identified from Medline, Embase, Cochrane Library, and those in Chinese from Wanfang database and CNKI database.

Gastrosplenic fistula due to splenic large B-cell lymphoma.

A gastrosplenic fistula (GSF) is an unusual complication arising from a variety of primary gastric or splenic malignant lesions and less commonly from benign diseases. Splenic large cell lymphoma may be a main cause of this distinctive complication. We report a case of 62-year-old male with spontaneous GSF due to pathologically proven splenic large cell lymphoma who was diagnosed by computed tomography and treated successfully by surgical management.

[Laparoscopic radical cystectomy with orthotopic ileal neobladder in the treatment of invasive bladder cancer].

Objective: To study the technique and outcomes of laparoscopic radical cystectomy (LRC) and evaluate the efficacy of the urinary reservoir constructed with ileum in patients with invasive bladder cancer.

Methods: From 2005 - 2010, A total of 11 patients with bladder cancer were enrolled in this study. Laparoscopy was performed with 5 trocars.

[Expression and significance of Slug, E-cadherin and N-cadherin in gastrointestinal stromal tumors].

Objective: To explore the expression and clinical significance of Slug, E-cadherin and N-cadherin in gastrointestinal stromal tumors (GIST).

Methods: Seventy eight GIST specimens removed surgically from 2004 to 2007 were collected from the Department of Gastrointestinal Surgery at Guizhou Provincial People's Hospital. There were 48 males and 30 females with an age range of 28 - 87 years old.