Publications by authors named "Shaoyi Mei"
The quantitative level of steroid hormones (SHs) in some body fluids have been accepted for clinical diagnosis, whereas their distribution in aqueous humor (AH) is unknown yet. Herein, a profiling study was conducted with a total of 171 AH and 107 plasma samples using liquid chromatography coupled with tandem mass spectrometry (LC MS/MS). For the first time, six kinds of SHs in AH were quantitatively estimated, and their abundances were ranked at cortisol (F), corticosterone (COR), androstenedione (A2), and 11-deoxycortisol (11DOC).
View Article and Find Full Text PDFPrevious studies have shown that gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study.
View Article and Find Full Text PDFCongenital cataract, an ocular disease predominantly occurring within the first decade of life, is one of the leading causes of blindness in children. However, the molecular mechanisms underlying the pathogenesis of congenital cataract remain incompletely defined. Through whole-exome sequencing of a Chinese family with congenital cataract, we identified a potential pathological variant (p.
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- Researchers are studying a condition called Fuchs endothelial corneal dystrophy (FECD) to find new treatments using special software that looks at gene expression data from patients.
- They compared gene activity in eye cells from FECD patients and healthy individuals to see what makes the disease different.
- The findings showed that certain genes are linked to FECD, and the software suggested that a type of drug called HDAC inhibitors might help treat the disease by fixing the abnormal gene activity.
Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are well-known key immune checkpoints that play a crucial dampening effect on regulating T-cell homeostasis and self-tolerance. In this study, we aimed to evaluate the association between immune checkpoints (CTLA-4 and PD-1) and Posner-Schlossman syndrome (PSS) in a southern Chinese population. A total of 137 patients with PSS and 139 healthy controls from a southern Chinese population were recruited.
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- The study investigates the role of human leucocyte antigen (HLA) class I and II genes in the development of Graves' ophthalmopathy (GO) among a Southern Chinese population.
- It analyzes genetic data from 272 patients with Graves' disease and GO phenotypes, comparing it to 411 control subjects, revealing significant differences in allele and haplotype frequencies linked to the disease.
- The findings suggest specific HLA alleles and haplotypes as potential risk factors for Graves' disease and GO, along with certain epitopes from TSHR and IGF-1R that may help in understanding the immune response involved in the disease.
Background: The polymorphisms of classical and loci have been associated with Posner-Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical (e.g.
View Article and Find Full Text PDFBackground: To investigate the genetic causes and clinical characteristics of dominant optic atrophy (DOA) in a Chinese family.
Methods: A 5-generation pedigree of 35 family members including 12 individuals affected with DOA was recruited from Shenzhen Eye Hospital, China. Four affected family members and one unaffected family member were selected for whole exome sequencing.
Genomic full length sequence of HLA-A*24:20:01:01, was identified by cloning and sequencing from a Chinese donor.
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