Common variants of and contribute to susceptibility to hand osteoarthritis and related pain.

To examine the relationship of the and genes with hand osteoarthritis (HOA) susceptibility risk, clinical severity and pain. A total of 3740 subjects comprising 1180 participants with HOA and 2560 controls were enrolled. Genetic association was evaluated at both single marker and haplotype levels using PLINK.

The effect of common variants in GDF5 gene on the susceptibility to chronic postsurgical pain.

Background: The growth differentiation factor 5 (GDF5) gene regulates the growth of neuronal axons and dendrites and plays a role in the inflammatory response and tissue damage. The gene may also be associated with chronic postsurgical pain. This study aimed to reveal the relationship between SNPs in the GDF5 gene and orthopedic chronic postsurgical pain in Han Chinese population based on a case-control study.