Publications by authors named "Shaoxiong Liu"

Article Synopsis
  • Fasciola hepatica, a foodborne parasite, poses health risks to humans and livestock and causes economic losses, particularly in resource-limited areas.
  • A new detection method combining recombinase polymerase amplification (RPA) with CRISPR/Cas12a has been developed, allowing for quick and visually observable results using various techniques, such as fluorescence and lateral flow strips.
  • The assay demonstrates high sensitivity and specificity, showing over 98% agreement with established testing methods and proving effective for diagnosing F. hepatica in both sheep and humans, making it suitable for point-of-care applications.
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The histological origins and classification of Siewert II esophageal gastric junction (EGJ) adenocarcinomas are controversial. While the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system suggests that they be classified as esophageal cancer, some scholars insist that these cancers include a Barrett esophageal (BE) adenocarcinoma form and a gastric adenocarcinoma form. To obtain data relevant to this debate, in this study, a multi-center sample of 25 cases of Siewert II EGJ adenocarcinoma spanning a 6-year period were analyzed.

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Recently, virtual staining techniques have attracted more and more attention, which can help bypass the chemical staining process of traditional histopathological examination, saving time and resources. Meanwhile, as an emerging tool to characterize specific tissue structures in a label-free manner, the Mueller matrix microscopy can supplement more structural information that may not be apparent in bright-field images. In this Letter, we propose the Mueller matrix guided generative adversarial networks (MMG-GAN).

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The present study introduces a novel fungus, , which was identified in the southwestern region of China. The new species is characterized by a pileus that ranges in color from light orange-red to orange-red; the pileus has a wrinkled surface and is accompanied by a persistent annulus that is membranous and floccose-scaly. Above the annulus, the color transitions from white to yellowish brown.

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Supported metal pair sites have sparked interest due to their tremendous potential as bifunctional catalysts. Here, we report the structural Ni-Ni pair sites constructed in a well-defined nanocrystal phase of NiP. These Ni-Ni pair sites exhibited a remarkable product formation rate of 123 mol/mol/h for the hydrogenation of benzonitrile (BN) to benzylamine (BA).

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Fasciolosis is a global zoonotic parasitic disease caused by infection that is particularly harmful to cattle and sheep. A biotin-streptavidin signal amplification ELISA (streptavidin-ELISA/SA-ELISA) based on circulating antigens can allow for the early detection of -infected animals and is suitable for batch detection. It is considered to be a better means of detecting infection than traditional detection methods.

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NASICON-structured Ti-based polyanion compounds benefit from a stable structural framework, large ion channels, and fast ion mobility. However, the large radius of potassium and its poor electronic conductivity restrict its use in potassium-ion batteries. Herein, hierarchical mesoporous MnTi(PO)@C microspheres have been successfully synthesized using a simple electrospraying method.

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For in-vivo polarimetry such as Mueller matrix endoscopy of human internal organ cavities, the complicated undulating tissue surfaces deliver an inescapable occurrence of oblique incidence, which induce a prominent aberration to backscattering tissue polarimetry. In this Letter, we quantitatively analyze such polarimetric aberration on polarization basic parameters derived from the Mueller matrix. A correlation heatmap is obtained as applicable criteria to select an appropriate incident angle for different polarization basic parameters.

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Metal-organic frameworks (MOFs) with different functional groups have wide applications, while the understanding of functionalization influences remains insufficient. Previous researches focused on the static changes in electronic structure or chemical environment, while it is unclear in the aspect of dynamic influence, especially in the direct imaging of dynamic changes after functionalization. Here we use integrated differential phase contrast scanning transmission electron microscopy (iDPC-STEM) to directly 'see' the rotation properties of benzene rings in the linkers of UiO-66, and observe the high correlation between local rigidity and the functional groups on the organic linkers.

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Significance: Among the available polarimetric techniques, backscattering Mueller matrix (MM) polarimetry provides a promising non-contact and quantitative tool for tissue detection and clinical diagnosis. To eliminate the surface reflection from the sample cost-effectively, the non-collinear backscattering MM imaging setup always has an oblique incidence. Meanwhile, for practical organ cavities imaged using polarimetric gastrointestinal endoscopy, the uneven tissue surfaces can induce various relative oblique incidences inevitably, which can affect the polarimetry in a complicated manner and needs to be considered for detailed study.

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Time-division framework is commonly used in Mueller matrix polarimeters (MPs), which takes extra numbers of images at the same position in an acquisition sequence. In this Letter, we utilize measurement redundancy to raise a unique loss function which can reflect and evaluate the degree of mis-registration of Mueller matrix (MM) polarimetric images. Further, we demonstrate that the constant-step rotating MPs have a self-registration loss function free from systematic errors.

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Atomically dispersed metals encapsulated in metal-organic frameworks (MOFs) have attracted extensive attention in catalysis and energy fields. Amino groups were considered conducive to the formation of single atom catalysts (SACs) due to the strong metal-linker interactions. Here, atomic details of Pt@UiO-66 and Pd@UiO-66-NH are revealed using low-dose integrated differential phase contrast scanning transmission electron microscopy (iDPC-STEM).

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is an apicomplexan parasite that infects many mammals and remains a threatening disease worldwide because of the lack of effective drugs and vaccines. Our previous studies demonstrated that 14-3-3 protein (Nc14-3-3), which is included in extracellular vesicles (NEVs), can induce effective immune responses and stimulate cytokine expression in mouse peritoneal macrophages. However, whether Nc14-3-3 has a protective effect and its mechanisms are poorly understood.

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Polarization imaging techniques are emerging tools to provide quantitative information of anisotropic structures, such as the density and orientation distribution of fibers in tissue samples. Recently, it is found that when using Mueller matrix polarimetry to obtain the structural features of tissue samples, some information can be revealed by relatively low-resolution polarization parameter images. Thus, to analyze what kinds of anisotropic optical and structural information contained in high-resolution polarization images are preserved in low-resolution ones, here we carry out a comparative study of the influence of imaging resolution on the Mueller matrix derived linear retardance parameters.

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Recently, we developed a label-free method to probe the microstructural information and optical properties of unstained thin tissue slices based on microscopic Mueller matrix imaging technique. In this paper, we take the microscopic Mueller matrix images of human breast ductal carcinoma tissue samples at different pathological stages, and then calculate and analyze their retardance-related Mueller matrix-derived parameters. To reveal the microstructural features more quantitatively and precisely, we propose a new method based on first-order statistical properties of image to transform the 2D images of Mueller matrix parameters into several statistical feature vectors.

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Background: Neospora caninum is an obligate intracellular protozoan that causes neosporosis, N. caninum infection is a major cause of abortion in cattle worldwide. Currently, specific treatment for neosporosis is not available.

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Objective: Mueller matrix polarimetry technique has been regarded as a powerful tool for probing the microstructural information of tissues. The multiplying of cells and remodeling of collagen fibers in breast carcinoma tissues have been reported to be related to patient survival and prognosis, and they give rise to observable patterns in hematoxylin and eosin (H&E) sections of typical breast tissues (TBTs) that the pathologist can label as three distinctive pathological features (DPFs)-cell nuclei, aligned collagen, and disorganized collagen. The aim of this paper is to propose a pixel-based extraction approach of polarimetry feature parameters (PFPs) using a linear discriminant analysis (LDA) classifier.

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Organogenesis, including renal development, requires an appropriate retinoic acid concentration, which is established by differential expression of aldehyde dehydrogenase 1 family member A2 () and cytochrome P450 family 26 subfamily A/B/C member 1 (). In the fetal kidney, expresses in the developing stroma and renal vesicle and its derivatives but does not present in the ureteric bud. It remains unclear what may contribute to this expression pattern.

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Graded index (GRIN) lenses are commonly used for compact imaging systems. It is not widely appreciated that the ion-exchange process that creates the rotationally symmetric GRIN lens index profile also causes a symmetric birefringence variation. This property is usually considered a nuisance, such that manufacturing processes are optimized to keep it to a minimum.

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Background: Due to the recent advances in deep learning, this model attracted researchers who have applied it to medical image analysis. However, pathological image analysis based on deep learning networks faces a number of challenges, such as the high resolution (gigapixel) of pathological images and the lack of annotation capabilities. To address these challenges, we propose a training strategy called deep-reverse active learning (DRAL) and atrous DenseNet (ADN) for pathological image classification.

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Background: Infiltrating ductal carcinoma (IDCA) is the most common form of invasive breast cancer. Immunohistochemistry (IHC) is widely used to analyze estrogen receptor 1 (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) that can help classify the tumor to guide the medical treatment. IHC examinations require experienced pathologists to provide interpretations that are subjective, thereby lowering the reproducibility of IHC-based diagnosis.

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Morphological variations, particularly flower colour, could be considered as an evolutionarily and ornamentally significant taxonomic criterion for . Our extensive field investigation based on population studies revealed abundant intraspecific variations in flower colour. Five species, (i.

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Mueller matrix polarimetry is a potentially powerful tool for biomedical diagnosis. Recently, the transmission Mueller matrix microscope and backscattering Mueller matrix endoscope were developed and applied to various pathological samples. However, a comparative study of imaging contrasts of Mueller matrix derived parameters between transmission and backscattering measurements is still needed to help decide which information obtained from transmission Mueller matrix microscope can be directly applied to Mueller matrix imaging.

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Herein, fluorescence lifetime imaging microscopy (FLIM) was used to directly measure eosin fluorescence lifetimes from H&E-stained umbilical artery, and a further utilization of eosin for high-content and multi-target analysis was proposed for the first time. Smooth muscles, collagens, and elastic fibers can be distinguished by eosin fluorescence lifetimes (P < 0.001).

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