Involvement of energy and cell wall metabolisms in chilling tolerance improved by hydrogen sulfide in cold-stored tomato fruits.

Hydrogen sulfide improved cold resistance of tomato fruits by regulating energy metabolism and delaying cell wall degradation, thereby alleviating the damage of cold storage on fruits. Postharvest cold storage in tomato fruits extended shelf life but caused the appearance of chilling injury (CI), appeared by softness and spots on the surface of the fruits. These changes were linked closely with energy and cell wall metabolisms.

Statistical Analysis of Morphological Characteristics of Inconel 718 Formed by High Deposition Rate and High Laser Power Laser Cladding.

Laser cladding is one of the emerging additive manufacturing technologies and has been adopted in various industrial fields. In this study, the morphological characteristics of a single clad of Inconel 718 manufactured by coaxial laser cladding with high laser power from 4200 W to 5400 W, powder feeding rate from 25 g/min to 50 g/min, and cladding speed from 20 mm/s to 50 mm/s are studied. The cross-section of the melt pool is analyzed and classified by type into three types: shallow dilution, flat dilution, and fluctuating dilution.

Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies.

Background: The diagnostic criteria for abdominal obesity are usually waist circumference or waist-to-hip ratio. The magnitude of the risks for cancers of the digestive system and abdominal obesity is unknown. To assess whether abdominal obesity increases the risk of digestive cancer, we conducted a systematic review and meta-analysis of prospective cohort studies in a database.

Effect of Laser Beam Profile on Thermal Transfer, Fluid Flow and Solidification Parameters during Laser-Based Directed Energy Deposition of Inconel 718.

The profile of the laser beam plays a significant role in determining the heat input on the deposition surface, further affecting the molten pool dynamics during laser-based directed energy deposition. The evolution of molten pool under two types of laser beam, super-Gaussian beam (SGB) and Gaussian beam (GB), was simulated using a three-dimensional numerical model. Two basic physical processes, the laser-powder interaction and the molten pool dynamics, were considered in the model.

Role of Surface-Active Element Sulfur on Thermal Behavior, Driving Forces, Fluid Flow and Solute Dilution in Laser Linear Welding of Dissimilar Metals.

Understanding heat and mass transfer and fluid flow in the molten pool is very helpful in the selection and optimization of processing parameters, and the surface-active element has an important effect on the heat and mass transfer in laser welding of dissimilar metals. A three-dimensional (3D) numerical model coupled with a sub-model of surface tension, which considers the influence of local temperature and the concentration of surface-active element sulfur at the gas/liquid surface, is used to analyze the thermal behavior, driving forces, fluid flow, and solute dilution during laser linear welding of 304SS and Ni. The relationship between surface tension, driving forces, and the temperature coefficient of surface tension with the spatial distribution of temperature and the surface-active element sulfur is quantitatively analyzed.

Hole Morphology and Keyhole Evolution during Single Pulse Laser Drilling on Polyether-Ether-Ketone (PEEK).

Polyether-ether-ketone (PEEK), with its superior mechanical, chemical, and thermal properties, as well as high biocompatibility, has been used in aerospace, electronics, and biomedical applications. In this paper, a large number of experiments of single-pulse laser drilling on PEEK were performed to analyze the hole morphology and keyhole evolution, which were characterized by an optical microscope, charge-coupled device (CCD), and high-speed camera. A novel method is proposed to observe and measure the dimension of the processed hole rapidly right after laser drilling for special polymer materials with wear-resistance and non-conductivity.

Inokosterone Is A Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients: Analysis from Active Ingredient of Cyathula Officinalis.

Objective: To elucidate the active compounds and the molecular mechanism of Cyathula Officinalis as a drug treatment for rheumatoid arthritis (RA).

Methods: The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine. The protein-protein interaction between the target genes were analyzed using STRING and Genemania.

miRNA-302e attenuates inflammation in infantile pneumonia though the RelA/BRD4/NF-κB signaling pathway.

In the present study, the main focus was investigating the role of microRNA (miRNA)‑302e in infantile pneumonia (IP) and exploring the potential protective mechanisms. Briefly, the expression of miRNA‑302e was reduced in a mouse model of IP. In addition, the administration of anti‑miRNA‑302e increased inflammation and induced the protein expression of RelA, bromodomain‑containing protein 4 (BRD4) and nuclear factor (NF)‑κB in the in vitro model of IP.

Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer.

Objective: This study explored the ability of microRNA-135a (miR-135a) to influence cell proliferation, migration, invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer (NSCLC).

Methods: NSCLC tissues and adjacent normal tissues were collected from 138 NSCLC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of miR-135a and IGF-1, PI3K, Akt, VEGF, bFGF and IL-8 mRNA; western blotting was used to determine the expression levels of IGF-1, PI3K and Akt protein; and enzyme-linked immunosorbent assay (ELISA) was used to analyze the expression levels of VEGF, bFGF and IL-8 protein.

A combination of four effective components derived from Sheng-mai san attenuates hydrogen peroxide-induced injury in PC12 cells through inhibiting Akt and MAPK signaling pathways.

The present study was designed to investigate whether a combination of four effective components derived from Sheng-mai san (SMXZF; ginsenoside Rb1: ginsenoside Rg1: DT-13: Schizandrol A as 6 : 9 : 4 : 5) could attenuate hydrogen peroxide (H2O2)-induced injury in PC12 cells, focusing on the Akt and MAPK pathways . The PC12 cells were exposed to H2O2 (400 μmol·L(-1)) for 1 h in the presence or absence of SMXZF pre-treatment for 24 h. Cell viability was measured by MTT assay.

Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease.

Aim: To illuminate the molecular targets for schisandrin against cerebrovascular disease based on the combined methods of network pharmacology prediction and experimental verification.

Method: A protein database was established through constructing the drug-protein network from literature mining data. The protein-protein network was built through an in-depth exploration of the relationships between the proteins.

Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.

The previous published data on the association between the 8-oxo-guanine glycosylase-1 (OGG1) and apurinic/apyrimidinic-endonuclease-1 (APEX1/APE1) polymorphisms and lung cancer risk remained controversial. Several polymorphisms in the OGG1 and APEX1 gene have been described, including the commonly occurring Ser326Cys in OGG1 and Asp148Glu in APEX1. This meta-analysis of literatures was performed to derive a more precise estimation of the relationship.

Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,199 cases and 38,922 controls.

Many studies have reported the role of COMT Val158Met with breast cancer risk, but the results remained controversial. In addition, previous meta-analysis on COMT Val158Met showed conflicting results. Hence, we performed a meta-analysis to investigate the association between breast cancer and COMT Val158Met (30,199 cases and 38,922 controls) in different inheritance models.

[Determination of 15 volatile organic compound residues in cosmetics by headspace gas chromatography].

A headspace gas chromatography (HS-GC) method was developed for the rapid determination of multimixture of 15 residual volatile organic compounds in cosmetics. The experimental conditions of HS-GC such as headspace temperature, headspace time and the analytical conditions of GC were optimized. Cosmetic samples were extracted and cleaned-up by headspace at 60 degrees C for 30 min, determined by GC-flame ionization detector (FID) and quantified by external standard method.

Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis.

Colorectal cancer (CRC) arises as the consequence of progressive changes from normal epithelial cells through polyp to tumor, and thus is an useful model for studying metabolic shift. In the present study, we studied the metabolomic profiles using high analyte specific gas chromatography/mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) to attain a systems-level view of the shift in metabolism in cells progressing along the path to CRC. Colonic tissues including tumor, polyps and adjacent matched normal mucosa from 26 patients with sporadic CRC from freshly isolated resections were used for this study.

Quasi-Dammann grating with proportional intensity array spots.

A quasi-Dammann grating is proposed to generate array spots with proportional-intensity orders in the far field. To describe the performance of the grating, the uniformities of the array spots are redefined. A two-dimensional even-sampling encode scheme is adopted to design the quasi-Dammann grating.

[A method for determination of volatile organic compounds in drinking water by purge and trap in combination with gas chromatograph/mass spectrometry].

Objective: To establish a method of purge and trap in combination with gas chromatograph/mass spectrometry(P and T-GC/MS) for the rapid determination of minimum multi-mixture of volatile organic compounds (VOCs) in drinking water simultaneously.

Methods: The experimental conditions of P and T, such as desorption temperature, desorption time, the type of the trap and the analytical conditions of GC were optimized. 54 VOCs in drinking water were determined by P and T-GC/MS.

[Luminescence properties of rare earth ions in 2SrO.0.84 P2O5.0.16 B2O3: RE3+ (RE=Ce, Tb)].

The phosphors of 2SrO.0.84 P2O5.

[VUV spectral properties of (Y, Gd) Al3 (BO3)4: Tb].

(Y, Gd)A13 (BO3)4 doped with Ce and Tb were prepared by solid state reaction. The structure, VUV excitation properties, excitation were studied. (Y,Gd)Al3 (BO3)4 belongs to trigonal crystal system with thespace group of R32, and the crystal structure does not change as Tb3+ and Ce3+ ions are doped to the crystal lattice.

[Luminescence properties and spectral analysis of long phosphorescent phosphors: Ba(1 - x) Ca (x) Al2O4 : Eu2+, RE3+].

New long phosphorescent phosphors Ba(1 -x),Ca(x)Al2O4 : Eu2+, RE3+ (RE3+ = Dy3+, Nd3+) with tunable color emission have been prepared by solid state reaction. The luminescence properties of the samples are discussed and analyzed. The emission spectra show that the tuning range of the color emission of the phosphors is between 498 and 440 nm, which is determined by x, under the excitation of UV.