Identification of Hub Genes and Physiological Effects of Overexpressing the Photosynthesis-Related Gene in Tomato under High-CO Conditions.

Changes in the atmospheric CO concentration influence plant growth and development by affecting the morphological structure and photosynthetic performance. Despite evidence for the macro-effects of elevated CO concentrations on plant morphology and yield in tomato, the gene regulatory network and key genes related to cross-regulation have not been reported. To identify the hub genes and metabolic pathways involved in the response of tomato to CO enrichment, weighted gene co-expression network analysis was conducted using gene expression profiles obtained by RNA sequencing.

Sialidase facilitates immune evasion by reducing M1 polarization, antigen presentation, and phagocytosis of infected macrophages.

Background: (), a major pathogen of periodontitis, can evade host immune defenses. Previously, we found that W83 sialidase gene mutant strain (ΔPG0352) was more easily cleared by macrophages. The aims of this study were to investigate the effects of sialidase in on the polarization, antigen presentation, and phagocytosis of infected macrophages and to clarify the mechanism of immune evasion.

Porphyromonas gingivalis msRNA P.G_45033 induces amyloid-β production by enhancing glycolysis and histone lactylation in macrophages.

Background: High expression of amyloid-β (Aβ) in periodontal tissue could contribute to exacerbating the development of both periodontitis and Alzheimer's disease (AD). Porphyromonas gingivalis (P. gingivalis) as a periodontal pathogen expresses msRNAs, which can regulate gene transcription in host cells.

Prediction of IDH mutation status of glioma based on terahertz spectral data.

Gliomas are the most common type of primary tumor in the central nervous system in adults. Isocitrate dehydrogenase (IDH) mutation status is an important molecular biomarker for adult diffuse gliomas. In this study, we were aiming to predict IDH mutation status based on terahertz time-domain spectroscopy technology.

Porphyromonas gingivalis survival skills: Immune evasion.

Periodontitis is a chronic inflammatory condition that destroys the tooth-supporting tissues and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis endangers the oral health of 70% of people throughout the world. Periodontitis is also related to various systemic diseases, such as diabetes mellitus, atherosclerosis, and rheumatoid arthritis, which not only has a great impact on population health status and the quality of life but also increases the social burden.

The sialidase inhibitor, DANA, reduces Porphyromonas gingivalis pathogenicity and exerts anti-inflammatory effects: An in vitro and in vivo experiment.

Background: Sialidase has an important role in the pathogenesis of periodontitis and Porphyromonas gingivalis is a sialidase-producing organism implicated in periodontitis development. The aim of this study was to evaluate the anti-virulence and anti-inflammatory properties of the sialidase inhibitor, 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA), in vitro and in vivo.

Methods: The effects of DANA on P.