Publications by authors named "Shaoqing Huang"
Pulmonary hamartomas are common. However, extrapulmonary hamartomas on the Visceral Pleura are very rare. We treated a patient with a pulmonary nodule at the left lower lobe by uniportal video-assisted thoracoscopic wedge resection, which showed a yellow nodule located on the visceral pleura.
View Article and Find Full Text PDFIntroduction: Hypoxia stress renders aquatic animals more susceptible to bacterial disease, yet the underlying mechanism remains elusive.
Methods: We conducted an acute hypoxia stress experiment to investigate the impact of stress on the immune response of via transcriptome analysis, RT-qPCR and Western blot.
Results: Our results showed that acute hypoxia stress disrupted the tissue architecture, and significantly changed the gene expression profiles in the hepatopancreas of shrimp.
Article Synopsis
- Closed chest drainage is crucial after certain lung surgeries to remove fluids and maintain lung function, with traditional systems being single, double, or triple-chamber types, each with unique pros and cons.
- Recent advancements include a patented micro air pump-integrated drainage bottle designed to allow patient mobility during therapy, which could enhance recovery times.
- The new device boasts both clinical applications and cost-effectiveness, particularly benefiting economically challenged areas, and has been developed through 3D printing techniques.
Article Synopsis
- The liver is the most common site for metastasis from gastrointestinal stromal tumors (GISTs), and the study aimed to assess how imatinib (IM) combined with hepatic resection (HR) or local treatments affects long-term survival compared to IM alone.
- Out of 238 patients studied with GIST liver metastases, those receiving IM combined with HR had significantly better overall survival rates (91.9%) compared to those on IM alone (61.1%) or those receiving IM with other local treatments (55.2%).
- The research concluded that combining IM with HR could enhance overall survival in selected patients, especially when achieving no evidence of disease through surgical intervention.
Objectives: To explore the auxiliary value of combining CT features with existing response evaluation criteria in the prediction of progressive disease (PD) in gastrointestinal stromal tumors (GIST) patients treated with sunitinib.
Material And Methods: Eighty-one patients with GISTs who received sunitinib were included in this retrospective multicenter study and divided into training and external validation cohorts. Progression at six months was determined as a reference standard.
Article Synopsis
- A study compared the effectiveness of increasing imatinib dosage versus switching to sunitinib for patients with gastrointestinal stromal tumors (GISTs) who did not respond to the standard 400 mg/day imatinib treatment.
- The results showed that patients who switched directly to sunitinib had a significantly longer progression-free survival (12 months) compared to those who escalated their imatinib dosage (5 months).
- However, when patients who switched to sunitinib were evaluated for time to sunitinib failure and overall survival, there were no significant differences between the two groups, suggesting the need for further research on which patients benefit most from increasing imatinib dosage.
Objectives: To investigate the ability of CT and endoscopic sonography (EUS) in predicting the malignant risk of 1-2-cm gastric gastrointestinal stromal tumors (gGISTs) and to clarify whether radiomics could be applied for risk stratification.
Methods: A total of 151 pathologically confirmed 1-2-cm gGISTs from seven institutions were identified by contrast-enhanced CT scans between January 2010 and March 2021. A detailed description of EUS morphological features was available for 73 gGISTs.
Background: Carney-Stratakis syndrome (CSS) is a rare dyad of paraganglioma (PGL)/pheochromocytoma (PHEO) and gastrointestinal stromal tumor (GIST). PGLs are neuroendocrine tumors of neural crest origin which are mostly found in the head, neck, and retroperitoneal space. GISTs are the most common mesenchymal tumors of the digestive tract, usually caused by mutations.
View Article and Find Full Text PDFBackground: Tyrosine kinase inhibitors (TKIs) are currently the main treatment choice for gastrointestinal stromal tumors (GISTs). However, the long-term use of TKIs can lead to drug resistance. There is no study or clinical report of combination therapies of TKIs that have been approved for marketing.
View Article and Find Full Text PDFArticle Synopsis
- Diagnosing rare pulmonary mycosis, particularly due to pathogens like Exophiala dermatitidis, is challenging due to limited understanding and the absence of specific detection markers.
- A case involving a 52-year-old man showed that traditional biopsy methods failed to identify the pathogen, prompting the use of combined tissue metagenomic next-generation sequencing (mNGS) which successfully identified Exophiala dermatitidis.
- The study suggests that integrating mNGS with conventional microbiological testing can enhance the diagnosis of rare fungal infections, highlighting the need for proper follow-up care.
Circular RNAs (circRNAs), which fall into the category of endogenous ncRNAs, are linked to disease progression of neoplastic diseases. Whereas, it remains uncharacterized regarding hsa_circ_0072309's function and implications in lung carcinoma (LC). Gene Expression Omnibus (GEO) database was utilized for identifying circRNAs with aberrantly expression in LC.
View Article and Find Full Text PDFArticle Synopsis
- Gastrointestinal stromal tumors (GIST) are the most common type of mesenchymal tumors in the gastrointestinal tract, typically treated with surgery and tyrosine kinase inhibitors (TKIs), though resistance to TKIs can occur over time.
- A case study is presented of a 47-year-old woman with primary gastric GIST and liver metastases, who initially responded to imatinib therapy but faced disease progression after discontinuing the drug for 10 months.
- Following a secondary mutation and treatment failure, she was switched to ripretinib, which showed positive results, highlighting the importance of mutational analysis and ctDNA monitoring for tailored treatment strategies.
Objective: The effects of continuing nursing care under cognitive behavioral intervention on the psychological state and living quality of patients with double J catheter after ureterolithiasis surgery were analyzed in this research.
Methods: The research subjects in this study were 142 patients who were discharged from our hospital with a double J tube after ureterolithiasis surgeries from June 2019 to June 2020. According to the patient care plan, the subjects were divided into the control group (n=71) and the observation group (n=71) and respectively treated with routine basic nursing measures and continuing nursing care under cognitive-behavior intervention.
[The clinical efficacy of hemoperfusion in treatment of drug poisoning].
Zhonghua Nei Ke Za Zhi
August 2004
Objective: To investigate the ability of hemoperfusion to remove some drugs or toxin from the body and its clinical efficacy.
Methods: Sixty-nine cases of poisoning due to tetramine or other drugs poisoning in our hospital between July 1990 and December 2003 were studied. Thirty-four patients among them received conventional treatment (including early gastric lavage, hepatoprotection, diuresis or respiratory support), and the remaining were given conventional treatment and hemoperfusion.
[Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
October 2002
Objective: To examine the therapeutic effect of combined use of obidoxime and atropine with artificial ventilation on respiratory muscle paralysis caused by omethoate poisoning in rats.
Methods: Rats were exposed to 2 times the dose of LD50 omethoate and treated with atropine (10 mg/kg) to counteract cholinergic symptoms. When the rats' respiratory frequency became slower and breathed with difficulty, the trachea intubation and artificial ventilation was carried out.
[Experimental treatment of respiratory failure caused by omethoate poisoning in rats].
Zhonghua Nei Ke Za Zhi
April 2002
Objective: To examine the therapeutic effect of combined use of pralidoxime-Cl and atropine with artificial ventilation on respiratory muscle paralysis caused by omethoate poisoning in rats.
Methods: Rats were administered with same doses of 2LD(50) omethoate and then treated with atropine (10 mg/kg) to resist effectively chlolinergic symptoms. When the rats had slow respiratory frequency and breathed with difficulty, the trachea was intubated and artificial ventilation was carried out (except for group A).
Article Synopsis
- The study aimed to investigate the effectiveness of vitamin B(6) combined with sodium dimercaptopropane sulfonate (Na-DMPS) as an antidote for acute poisoning by tetramethylene disulphotetramine (TETS) in animals.
- Experiments showed that administering vitamin B(6) with Na-DMPS shortly after TETS exposure significantly reduced convulsions and lowered the death rate in mice.
- The findings indicate that this combination could extend survival time and suggests potential clinical applications for treating TETS poisoning in humans.