Study on the Role of Paclitaxel Nano-Drug Delivery System in Inhibiting Intimal Hyperplasia and Improving Vascular Remodeling in Abdominal Aortic Injury Model.

The surface-modified paclitaxel nanoparticles were prepared to observe its inhibitory effect on the intimal and mediator proliferation and the improvement of vascular remodeling after rabbit abdominal aortic injury. First, paclitaxel nanoparticles were prepared by ultrasonic emulsification solvent evaporation method. The surface of paclitaxel nanoparticles was modified by physical adsorption, the nanoparticles were characterized and the encapsulation efficiency was evaluated.

CDKN2B-AS1 Aggravates the Pathogenesis of Human Thoracic Aortic Dissection by Sponge to miR-320d.

In the present study, the role and molecular mechanism of long noncoding RNA CDKN2B-AS1 in human thoracic aortic dissection (TAD), a highly lethal cardiovascular disease, was investigated. The expression of CDKN2B-AS1 in human TAD and normal aortic tissues of donors were examined by quantitative real-time polymerase chain reaction. RNA pull-down assay and a series of luciferase reporter assays were performed to predict the relationships between CDKN2B-AS1, miR-320d, and STAT3.

Downregulating long non-coding RNA PVT1 expression inhibited the viability, migration and phenotypic switch of PDGF-BB-treated human aortic smooth muscle cells via targeting miR-27b-3p.

Long non-coding RNA Plasmacytoma Variant Translocation 1 (LncRNA PVT1) was involved in various human diseases, but its role in aortic dissection (AD) remained to be fully examined. In this study, the viability and migration of human aortic smooth muscle cells (HASMCs) were respectively measured by MTT assay and wound-healing assay. Relative phenotypic switch-related protein expressions were measured with quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot as needed.