Publications by authors named "Shaomao Zheng"
Idiopathic pulmonary fibrosis (IPF) is the most predominant type of idiopathic interstitial pneumonia and has an increasing incidence, poor prognosis, and unclear pathogenesis. In order to investigate the molecular mechanisms underlying IPF further, we performed single-cell RNA sequencing analysis on three healthy controls and five IPF lung tissue samples. The results revealed a significant shift in epithelial cells (ECs) phenotypes in IPF, which may be attributed to the differentiation of alveolar type 2 cells to basal cells.
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- Immune cells in the lungs play a role in idiopathic pulmonary fibrosis (IPF), but how different immune cell types contribute to this condition is still not well understood.
- A study using single-cell RNA sequencing revealed that CD8 T cells are more prevalent in IPF patients compared to those with non-fibrotic lungs, showing unique metabolic characteristics and signaling pathways related to fibrosis.
- The research suggests that CD8 T cells significantly impact the development of pulmonary fibrosis, which could help in creating targeted therapies for the condition.