Particle Coupling Mechanism inspired Adsorption Optimization in Autonomous in Vivo Computing.

While some commercial transceivers are available for capsule millirobots, no one has yet tackled the challenge of wireless communication between nanorobots inside the human body, which could be crucial for the control, and coordination of nanorobots. The Multi-agent system relies on information exchange by physical interactions or chemical secretions to perform complex tasks. Our previous work proposed a swarm coordination mechanism for tumor-target in an autonomous manner.

Tension-Relaxation In Vivo Computing Principle for Tumor Sensitization and Targeting.

By modeling the tumor sensitization and targeting (TST) as a natural computational process, we have proposed the framework of nanorobots-assisted in vivo computation. The externally manipulable nanorobots are steered to detect the tumor in the high-risk tissue, which is analogous to the process of searching for the optimal solution by the computing agents in the search space. To overcome the constraint of a nanorobotic platform that can only generate a uniform magnetic field to actuate the nanorobots, we have proposed the weak priority evolution strategy (WP-ES) in our previous works.

Nanorobots-Assisted Natural Computation for Multifocal Tumor Sensitization and Targeting.

We have proposed a new tumor sensitization and targeting (TST) framework, named in vivo computation, in our previous investigations. The problem of TST for an early and microscopic tumor is interpreted from the computational perspective with nanorobots being the "natural" computing agents, the high-risk tissue being the search space, the tumor targeted being the global optimal solution, and the tumor-triggered biological gradient field (BGF) providing the aided knowledge for fitness evaluation of nanorobots. This natural computation process can be seen as on-the-fly path planning for nanorobot swarms with an unknown target position, which is different from the traditional path planning methods.

In Vivo Computing Strategies for Tumor Sensitization and Targeting.

Several evolution strategies for in vivo computation are proposed with the aim of realizing tumor sensitization and targeting (TST) by externally manipulable nanoswimmers. In such targeting systems, nanoswimmers assembled by magnetic nanoparticles are externally manipulated to search for the tumor in the high-risk tissue by a rotating magnetic field produced by a coil system. This process can be interpreted as in vivo computation, where the tumor in the high-risk tissue corresponds to the global maximum or minimum of the in vivo optimization problem, the nanoswimmers are seen as the computational agents, the tumor-triggered biological gradient field (BGF) is used for fitness evaluation of the agents, and the high-risk tissue is the search space.

NGA-Inspired Nanorobots-Assisted Detection of Multifocal Cancer.

We propose a new framework of computing-inspired multifocal cancer detection procedure (MCDP). Under the rubric of MCDP, the tumor foci to be detected are regarded as solutions of the objective function, the tissue region around the cancer areas represents the parameter space, and the nanorobots loaded with contrast medium molecules for cancer detection correspond to the optimization agents. The process that the nanorobots detect tumors by swimming in the high-risk tissue region can be regarded as the process that the agents search for the solutions of an objective function in the parameter space with some constraints.

Perspective: Computational Nanobiosensing.

With the development of nanotechnology, externally manipulable or self-regulatable smart nanosystems can be utilized as effective tools for computational nanobiosensing, where natural computing strategies are exploited for knowledge-aided nanobiosensing.

Biosensing-by-Learning Direct Targeting Strategy for Enhanced Tumor Sensitization.

We propose a novel iterative-optimization-inspired direct targeting strategy (DTS) for smart nanosystems, which harness swarms of externally manipulable nanoswimmers assembled by magnetic nanoparticles (MNPs) for knowledge-aided tumor sensitization and targeting. We aim to demonstrate through computational experiments that the proposed DTS can significantly enhance the accumulation of MNPs in the tumor site, which serve as a contrast agent in various medical imaging modalities, by using the shortest possible physiological routes and with minimal systemic exposure. The epicenter of a tumor corresponds to the global maximum of an externally measurable objective function associated with an in vivo tumor-triggered biological gradient; the domain of the objective function is the tissue region at a high risk of malignancy; swarms of externally controllable magnetic nanoswimmers for tumor sensitization are modeled as the guess inputs.

Touchable Computing: Computing-Inspired Bio-Detection.

We propose a new computing-inspired bio-detection framework called touchable computing (TouchComp). Under the rubric of TouchComp, the best solution is the cancer to be detected, the parameter space is the tissue region at high risk of malignancy, and the agents are the nanorobots loaded with contrast medium molecules for tracking purpose. Subsequently, the cancer detection procedure (CDP) can be interpreted from the computational optimization perspective: a population of externally steerable agents (i.