Fundus Curvature as a Clinical Marker for Posterior Staphyloma Based on Widefield Optical Coherence Tomography.

Purpose: To investigate the ability to quantify fundus curvature and detect posterior staphyloma using widefield optical coherence tomography (OCT).

Design: Cross-sectional diagnostic evaluation.

Methods: This study reviewed 205 highly myopic eyes of 205 participants.

The safe lowest effective power of subthreshold micropulse laser treatment in Chinese patients with acute or chronic central serous chorioretinopathy.

Purpose: To assess the safe, lowest effective laser power of subthreshold micropulse laser (SML) for treating acute and chronic central serous chorioretinopathy (CSC) in Chinese patients.

Methods: Patients were distinguished with acute or chronic CSC based on focal or diffuse retinal pigment epithelium (RPE) leakage on fundus fluorescein angiography (FFA), with or without widespread RPE decompensation. Patients were categorized into five groups and treated with 577 nm yellow SML according to 50% titration power.

Regional assessment of choroidal vascularity index in patients with pre- and early-stage diabetic retinopathy using ultra-wide-field OCTA.

Purpose: To characterize the regional variations of choroidal vascularity index (CVI) in patients with diabetes mellitus (DM) using ultra-wide-field optical coherence tomography angiography (UWF-OCTA) and identify their correlations with the onset of diabetic retinopathy (DR).

Methods: This cross-sectional, monocular-sampling study recruited 141 participants from four age-matched groups: no DM (NDM), no DR with early DM (EDM) and late DM (LDM), and mild-moderate non-proliferative diabetic retinopathy (mNPDR). UWF-OCTA was employed for circular scans centered on the fovea.

An Artificial Universal Tactile Nociceptor Based on 2D Polymer Film Memristor Arrays with Tunable Resistance Switching Behaviors.

Nociceptor is an important receptor in the organism's sensory system; it can perceive harmful stimuli and send signals to the brain in order to protect the body in time. The injury degree of nociceptor can be divided into three stages: self-healing injury, treatable injury, and permanent injury. However, the current studies on nociceptor simulation are limited to the self-healing stage due to the limitation of the untunable resistance switching behavior of memristors.

Integrated Transcriptome Analysis of Long Noncoding RNA and mRNA in Developing and Aging Mouse Retina.

Mice have emerged as a widely employed model for investigating various retinal diseases. However, the availability of comprehensive datasets capturing the entire developmental and aging stages of the mouse retina, particularly during the elderly period, encompassing integrated lncRNA and mRNA expression profiles, is limited. In this study, we assembled a total of 18 retina samples from mice across 6 distinct stages of development and aging (5 days, 3 weeks, 6 weeks, 10 weeks, 6 months, and 15 months) to conduct integrated lncRNA and mRNA sequencing analysis.

Evaluation of an Artificial Intelligence System for the Detection of Diabetic Retinopathy in Chinese Community Healthcare Centers.

Objective: To evaluate the sensitivity and specificity of a Comprehensive Artificial Intelligence Retinal Expert (CARE) system for detecting diabetic retinopathy (DR) in a Chinese community population.

Methods: This was a cross-sectional, diagnostic study. Participants with a previous diagnosis of diabetes from three Chinese community healthcare centers were enrolled in the study.

Validation of the DIGIROP-birth model in a Chinese cohort.

Background: We aimed to validate the predictive performance of the DIGIROP-Birth model for identifying treatment-requiring retinopathy of prematurity (TR-ROP) in Chinese preterm infants to evaluate its generalizability across countries and races.

Methods: We retrospectively reviewed the medical records of preterm infants who were screened for retinopathy of prematurity (ROP) in a single Chinese hospital between June 2015 and August 2020. The predictive performance of the model for TR-ROP was assessed through the construction of a receiver-operating characteristic (ROC) curve and calculating the areas under the ROC curve (AUC), sensitivity, specificity, and positive and negative predictive values.

Universal artificial intelligence platform for collaborative management of cataracts.

Purpose: To establish and validate a universal artificial intelligence (AI) platform for collaborative management of cataracts involving multilevel clinical scenarios and explored an AI-based medical referral pattern to improve collaborative efficiency and resource coverage.

Methods: The training and validation datasets were derived from the Chinese Medical Alliance for Artificial Intelligence, covering multilevel healthcare facilities and capture modes. The datasets were labelled using a three-step strategy: (1) capture mode recognition; (2) cataract diagnosis as a normal lens, cataract or a postoperative eye and (3) detection of referable cataracts with respect to aetiology and severity.

Conversion of MoS to a Ternary MoSSe Alloy for High-Performance Sodium-Ion Batteries.

MoS has attracted tremendous attention as an anode for Na-ion batteries (NIBs) owing to its high specific capacity and layered graphite-like structure. Herein, MoS is converted to a ternary MoSSe alloy through the selenizing process in order to boost the electrochemical performance for Na-ion batteries. Conversion of MoS to MoSSe expands interlayer spacing, improves electronic conductivity, and creates more defects.

Vertically Oxygen-Incorporated MoS Nanosheets Coated on Carbon Fibers for Sodium-Ion Batteries.

Developing a high-performance anode with high reversible capacity, rate performance, and great cycling stability is highly important for sodium-ion batteries (SIBs). MoS has attracted extensive interest as the anode for SIBs. Herein, the vertically oxygen-incorporated MoS nanosheets/carbon fibers are constructed via a facile hydrothermal method and then by simple calcination in air.

Achieving a High-Performance Carbon Anode through the P-O Bond for Lithium-Ion Batteries.

Carbon materials with high initial Coulombic efficiency (ICE) and specific capacity in lithium-ion batteries are highly attractive. Herein, P-doped carbon has been prepared, and as an anode for lithium-ion batteries, it exhibits remarkably improved ICE and reversible capacity. P atoms are apt for the formation of the P-O bond in carbon with oxygen-containing groups.

Topographic profile of choroid in eyes after acute primary angle-closure.

Objective: To characterize and compare the topographic profile of choroid in eyes after acute primary angle-closure (APAC) and in normal controls.

Design, Setting, And Participants: A prospective observational study was conducted. Forty-four consecutive patients who had experienced unilateral APAC that was resolved by treatment were recruited.

Multiplex cytokine levels of aqueous humor in acute primary angle-closure patients: fellow eye comparison.

Background: The existing literature contains no information regarding inflammatory cytokine expression in unilateral acute primary angle-closure (APAC) affected eyes and fellow eyes with primary angle closure suspect (PACS). To measure levels of various inflammatory cytokines in the aqueous humor (AH) of APAC affected eyes and fellow eyes with a diagnosis of PACS (18 unilateral APAC eyes and 18 fellow eyes with PACS), and determine the underlying correlation between them.

Methods: The total levels of 12 cytokines including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), macrophage inflammatory protein (MIP)-1β, and vascular endothelial growth factor (VEGF) etc.

Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes.

Background: To report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT).

Methods: One hundred and forty-six healthy volunteers were consecutively recruited for this prospective observational study. Thickness of retina, RGC-related layers, and choroid in the standard early treatment of diabetic retinopathy study (ETDRS) grid were automatically measured using one SS-OCT (DRI OCT-1, Topcon, Japan).

Corneal Deformation Response in Patients With Primary Open-Angle Glaucoma and in Healthy Subjects Analyzed by Corvis ST.

Purpose: To compare corneal deformation response between patients with primary open-angle glaucoma (POAG) and healthy subjects. A prevalent case-control study was conducted, followed by an integrated meta-analysis.

Methods: Primary open-angle glaucoma was confirmed by presence of glaucomatous optic disc damage with corresponding visual field defect after excluding secondary causes.

Changes in retinal oxygen saturation, choroidal thickness, and retinal nerve fibre layer.

Objective: To investigate the changes of retinal oxygen saturation (Sat O2) concentrations, choroidal thickness (CT), and retinal nerve fibre layer (RNFL) in eyes with trabeculectomy-required acute primary angle closure (APAC).

Design: Prospective, longitudinal study.

Participants: Twenty-three eyes with trabeculectomy-required APAC were recruited.

Anterior and posterior ocular biometry in healthy Chinese subjects: data based on AS-OCT and SS-OCT.

Background: To measure the anterior and posterior ocular biometric characteristics concurrently and to determine the relationship between the iris and choroid in healthy Chinese subjects.

Methods: A total of 148 subjects (270 eyes) were enrolled in this cross-section study. The anterior and posterior ocular biometric characteristics were measured simultaneously by anterior segment optical coherence tomography (AS-OCT) and swept-source optical coherence tomography (SS-OCT).

Levels of angiogenesis-related vascular endothelial growth factor family in neovascular glaucoma eyes.

Purpose: This study aimed to evaluate the angiogenesis-related factors of the vascular endothelial growth factor (VEGF) family in the aqueous humour of patients with neovascular glaucoma (NVG).

Methods: This study involved 22 eyes of 22 patients with advanced NVG requiring antiglaucomatous surgery and 20 control subjects with cataracts. The NVG eyes received an intravitreal injection of ranibizumab (IVR) treatment before antiglaucomatous surgery.

Chemokine (C-C motif) ligand 2 and chemokine (C-C motif) ligand 7 in angle-closure glaucoma.

Purpose: To compare the concentrations of chemokine (C-C motif) ligand 2 (CCL2) and chemokine (C-C motif) ligand 7 (CCL7) in aqueous humour of eyes with acute primary angle-closure (APAC), primary angle-closure glaucoma (PACG) or with age-related cataract.

Methods: The prospective investigation included a study group of 56 patients (24 patients with APAC; 32 patients with PACG) undergoing glaucoma surgery and a control group of 21 patients undergoing routine cataract surgery. The interval between glaucoma attack and trabeculectomy was 19.

Aqueous humor concentration of VEGF and retinal oxygen saturation after unilateral acute primary angle closure.

Purpose: To measure the levels of vascular endothelial growth factor (VEGF) in aqueous humor in patients with unilateral acute primary angle closure (APAC) and retinal oxygen saturation (SO2 ) after trabeculectomy.

Methods: Twelve patients, with unilateral trabeculectomy-required APAC, were recruited as the study group. Aqueous humor samples were collected prospectively for every subject.

Enhanced depth imaging-optical coherence tomography of the choroid in moderate and severe primary angle-closure glaucoma.

Purpose: To compare the choroidal thickness (CT) in eyes with moderate and severe primary angle-closure glaucoma (PACG) with the eyes of healthy controls.

Methods: Fifty-nine patients (59 eyes) with PACG and 56 age-matched normal subjects underwent macular CT scanning using enhanced depth imaging-optical coherence tomography. The subjects with PACG were further classified as having moderate [-12 dB ≤ visual field mean deviation (VF-MD) ≤ -6 dB] or severe (VF-MD < -12 dB) glaucoma.

[Quality of life in patients with primary congenital glaucoma following antiglaucoma surgical management].

Objective: To evaluate the 23-item scale of Quality of Life (QOL) for patients with primary congenital glaucoma (PCG).

Methods: It was a cross-sectional study. The QOL scale specific for patients with PCG was firstly evaluated on 51 patients with PCG following antiglaucoma surgery at last followup visit (7.