Self-Immolative Photosensitizers for Self-Reported Cancer Phototheranostics.

Photosensitizers to precise target and change fluorescence upon light illumination could accurately self-report where and when the photosensitizers work, enabling us to visualize the therapeutic process and precisely regulate treatment outcomes, which is the unremitting pursuit of precision and personalized medicine. Here, we report self-immolative photosensitizers by adopting a strategy of light-manipulated oxidative cleavage of C═C bonds that can generate a burst of reactive oxygen species, to cleave to release self-reported red-emitting products and trigger nonapoptotic cell oncosis. Strong electron-withdrawing groups are found to effectively suppress the C═C bond cleavage and phototoxicity via studying the structure-activity relationship, allowing us to elaborate - that could temporarily inactivate the photosensitizer and quench the fluorescence by different glutathione (GSH)-responsive groups.

Comprehending scientific metaphors in the bilingual brain: Evidence from event-related potentials.

While the processing mechanisms of novel and conventional metaphors were widely investigated in previous monolingual studies, little attention has been devoted to how metaphoric utterances are processed by the bilingual brain as well as how scientific context might modulate such processes. Using event-related potentials (ERPs), this paper investigates the way in which scientific metaphors are electrophysiologically processed in Chinese (L1) and English (L2), with the aim of investigating the different mechanisms for understanding metaphorical language in first (L1) and second (L2) languages. By time-locking the N400 and later LPC time windows, the research show how meaning integration differs between L1 and L2 at different stages when comprehending figurative language.

Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis.

Breast cancer has been the most common cancer in women worldwide, and metastasis is the leading cause of death from breast cancer. Even though the study of breast cancer metastasis has been extensively carried out, the molecular mechanism is still not fully understood, and diagnosis and prognosis need to be improved. Breast cancer metastasis is a complicated process involving multiple physiological changes, and lung, brain, bone and liver are the main metastatic targets.

Bilingual Processing Mechanisms of Scientific Metaphors and Conventional Metaphors: Evidence a Contrastive Event-Related Potentials Study.

To study the different mechanisms of understanding figurative language in a speaker's native language (L1) and their second language (L2), this study investigated how scientific metaphors in Chinese (L1) and English (L2) are electrophysiologically processed event-related potential experimentation. Compared with the metaphors from daily life or in literary works, scientific metaphors tend to involve both a more complicated context structure and a distinct knowledge-inferencing process. During the N400 time window (300-500 ms), English scientific metaphors elicited more negative N400s than Chinese ones at the parietal region.

Hemispheric Processing of Chinese Scientific Metaphors: Evidence Hemifield Presentation.

The role of the two hemispheres in processing metaphoric language is controversial. In order to complement current debates, the current divided visual field (DVF) study introduced scientific metaphors as novel metaphors, presenting orientation mapping from the specific and familiar domains to the abstract and unfamiliar domains, to examine hemispheric asymmetry in metaphoric processing. Twenty-four Chinese native speakers from science disciplines took part in the experiment.

The epidemiology of acute occupational hand injuries treated in emergency departments in Foshan City, South China.

Background: Despite the magnitude of occupational hand injuries, there are no authoritative guidelines for hand injury prevention, and little research has been done to investigate the epidemiology of acute occupational hand injuries in South China or other developing areas. In this study, the epidemiology of acute occupational hand injuries treated in emergency departments (EDs) in Foshan City, South China, was examined and data were supplied to assist with preventive strategies in similar developing regions.

Methods: A multicenter study was prospectively designed and conducted in 5 large hospital EDs in Foshan City from July 2010 to June 2011.