Publications by authors named "Shaoju Gu"
Article Synopsis
- - The Sirtuins family, specifically SIRT6, plays a crucial role in protecting myocardial cells from damage and aging caused by the chemotherapy drug doxorubicin (DOX), as evidenced by its ability to inhibit oxidative stress and apoptosis in these cells.
- - In laboratory tests, SIRT6 overexpression was shown to reduce aging markers and inflammatory factors linked to DOX exposure, while silencing SIRT6 worsened cardiomyocyte injury, indicating its protective effects against DOX-induced damage.
- - Furthermore, SIRT6 enhances fatty acid oxidation-related gene expression through interaction with PPARα, and in animal models, its overexpression restored normal heart function, highlighting its potential as a therapeutic target for preventing DOX
Kinesin superfamily member 15 knockdown inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma.
Korean J Physiol Pharmacol
September 2023
The aim of this study was to investigate the role of kinesin superfamily member 15 (KIF15) in nasopharyngeal carcinogenesis (NPC) and explore its underlying mechanisms. We employed various assays, including the CCK-8 assay, flow cytometry, the Transwell and scratch assay, Western blotting, and nude mice transplantation tumor, to investigate the impact of KIF15 on NPC. Our findings demonstrate that KIF15 plays a critical role in the proliferation, apoptosis, migration, and invasion of NPC cells.
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