Publications by authors named "Shaojie Mi"
Article Synopsis
- * This study identified 235 distinct methylation sites in response to ionizing radiation (IR) in HEK293T cells, with 38% being previously unknown, highlighting several differentially methylated RNA-binding proteins.
- * It also discovered 14 novel methylation sites in proteins related to DNA damage response and showed that the methylation of PARP1 at K23 is vital for repairing DNA lesions, suggesting that a deficiency in this modification makes cancer cells more susceptible to radiation and replication stress.
Long non-coding RNAs (lncRNAs) are emerging regulators of genomic stability and human disease. However, the molecular mechanisms by which nuclear lncRNAs directly contribute to DNA damage responses remain largely unknown. Using RNA antisense purification coupled with quantitative mass spectrometry (RAP-qMS), we found that the lncRNA BGL3 binds to PARP1 and BARD1, exhibiting unexpected roles in homologous recombination.
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