Effects of ambient pressure on smoke propagation in inclined tunnel fires under natural ventilation.

This paper systematically studied the coupling effect of ambient pressure and tunnel slope on temperature distribution and smoke propagation in full-scale tunnel fires under natural ventilation by FDS. The downstream length (longitudinal length from fire source center to tunnel downstream exit) was also considered. The concept of "height difference of stack effect" was put forward when analyzing the mutual effect of tunnel slope and downstream length on smoke movement.

Study on R6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota-gut-brain axis.

The prevention, mitigation and treatment of depression has become a global issue that needs to be solved urgently. Sayram Ketteki, a traditional natural fermented yoghurt from the region with the world's fourth highest life expectancy, has been known as the "longevity secret", whose longevity and anti-depression factors are speculated to come from its rich microorganisms. Therefore, for the first time, we systematically studied in depth the microbes of Sayram Ketteki, screened a new edible probiotic strain, R6-3, and explored its anti-depression effect in chronic unpredictable mild stress (CUMS)-induced depression in mice.

Antifriction and Antiwear Effect of Lamellar ZrS2 Nanobelts as Lubricant Additives.

In this study, the tribological behavior of lamellar ZrS₂ nanobelts as lubricant additives was investigated under different concentrations, normal load, velocity, and temperature. The friction and wear tests were performed using a tribometer and with a reciprocating motion. The results indicate that the lamellar ZrS₂ nanobelt additives can effectively reduce the coefficient of friction and running-in time during the running-in period.

Tribological Behavior of Lamellar Molybdenum Trioxide as a Lubricant Additive.

In this study, the tribological behavior of lamellar MoO₃ as a lubricant additive was investigated under different concentrations, particle sizes, normal loads, velocity, and temperature. The friction and wear tests were performed using a tribometer and with a reciprocating motion. The results indicate that the friction-reducing ability and antiwear property of the base oil can be improved effectively with the addition of lamellar MoO₃.

Hippocampal β2‑microglobulin mediates sepsis‑induced cognitive impairment.

Acute brain dysfunction is a frequent complication in sepsis patients and is associated with long‑term neurocognitive consequences and increased mortality, yet the underlying mechanism remains unclear. Emerging evidence has suggested that β2‑microglobulin [a component of major histocompatibility complex (MHC) class I molecules] is involved in cognitive dysfunction in various neurological diseases. Therefore, the present study tested the hypothesis that β2‑microglobulin in the brain also mediates sepsis‑induced cognitive impairment.

Application of water@silica core-shell particles for suppressing gasoline pool fires.

A new type of dry powders with capsular structure was fabricated for fire suppression, in which the content of water approached 60%. The capsules with the size of 3-5μm consisted of liquid core and solid shell, where the core was water droplet and the shell was assembled silicon dioxide particles with surface hydrophobic modification. The shell of close-packed silica particles surrounding each water droplet provided the structural rigidity of the capsules and enabled their application as powder fire suppressants.

Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.

Sepsis-associated encephalopathy (SAE) is a common complication associated with poor prognosis in septic patients, but the underlying mechanism remains unclear. We hypothesized that disturbed neuregulin 1 (NRG1)-ErbB4 signaling in the parvalbumin interneurons was involved in sepsis-induced cognitive impairment in a mouse model of SAE. The SAE model was induced by cecal ligation/perforation (CLP).

Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis.

Some studies reported a significant association between polycystic ovary syndrome (PCOS) and risk of cardiovascular disease (CVD). However, the results are controversial. A systematic search was conducted in the PubMed, Science Direct, EMBASE, and Cochrane Library databases.

Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy.

Sepsis-associated encephalopathy (SAE) is a common complication in critically ill patients and is associated with a poor prognosis. However, the precise mechanisms underlying sepsis-induced cognitive impairment remain largely to be elucidated. The aim of the present study was to investigate whether indoleamine 2, 3-dioxygenase (IDO) activation-mediated neurotoxicity is involved in the pathophysiology of sepsis-induced cognitive impairment.

Characteristics of participants' and caregivers' influence on non-response in a cross-sectional study of dementia in an older population.

Objective: The issue of non-response in dementia epidemiological studies, which may result in the underestimation of the prevalence of dementia, has attracted little attention. We aimed to explore the causes and related factors of non-response in a dementia survey among Chinese veterans.

Methods: A two-phase, cross-sectional study investigated the prevalence of dementia and mild cognitive impairment in Chinese veterans aged ≥ 60 years.

Construction of the Chinese Veteran Clinical Research (CVCR) platform for the assessment of non-communicable diseases.

Background: Based on the excellent medical care and management system for Chinese veterans, as well as the detailed medical documentation available, we aim to construct a Chinese Veteran Clinical Research (CVCR) platform on non-communicable diseases (NCDs) and carry out studies of the primary disabling NCDs.

Methods: The Geriatric Neurology Department of Chinese People's Liberation Army General Hospital and veterans' hospitals serve as the leading and participating units in the platform construction. The fundamental constituents of the platform are veteran communities.