Selective Inhibition of P2Y and P2Y Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2-(1-Hydroxypentyl)-Benzoate, Puerarin and Salvianolic Acid B.

Aim: Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), puerarin and salvianolic acid B are three natural products or derivatives that can inhibit platelet aggregation. However, the mechanisms of dl-PHPB, puerarin and salvianolic acid B to inhibit platelet aggregation are still not clear.

Method: Here, 2-methylthioadenosine diphosphate (2-MeSADP) was used as an inducer to confirm the effects of three drugs on platelet aggregation and illustrate the corresponding mechanisms.

Toward 95.5% Efficient Red Emissive Carbon Dots: Oxidation State Enhancing Radiative Electron-Transition of Indole Fluorophore.

Red fluorescence carbon dots (CDs) are promising for diverse applications and have attracted tremendous research interest. However, it is still challenging to achieve red fluorescence CDs with high fluorescence quantum yields (QYs > 50%). Herein, three kinds of red fluorescence CDs with QYs of 53.

An automatic cough counting method and system construction for portable devices.

Introduction: Cough is a common symptom of respiratory diseases, and prolonged monitoring of cough can help assist doctors in making judgments about patients' conditions, among which cough frequency is an indicator that characterizes the state of the patient's lungs. Therefore, the aim of this paper is to design an automatic cough counting system to monitor the number of coughs per minute for a long period of time.

Methods: In this paper, a complete cough counting process is proposed, including denoising, segment extraction, eigenvalue calculation, recognition, and counting process; and a wearable automatic cough counting device containing acquisition and reception software.

Global transcriptional analysis for molecular responses of Alicyclobacillus acidoterrestris spores in drinking water after low- and medium-pressure ultraviolet irradiation.

Ultraviolet (UV) irradiation can effectively disinfect water contaminated with pathogens. However, the biological mechanisms of inactivation by different types of UV irradiation are unknown. The present study investigated the inactivation mechanisms of Alicyclobacillus acidoterrestris spores in water by low-pressure UV (LPUV) and medium-pressure UV (MPUV) using a quasi-collimated beam apparatus.

Seasonal variation and size distribution of aromatic acids in urban aerosols in Beijing, China.

Aromatic acids are an integral component of organic acids in the atmosphere, contributing to the formation of climate-altering brown carbon (BrC). To better understand the sources and formation processes of aromatic acids, we collected size-segregated particulate matter samples in urban Beijing from April 2017 to January 2018, which were analyzed using solvent-extraction followed by gas chromatography/mass spectrometry. Phthalic acid (o-PhA) had the greatest average annual concentration, followed by terephthalic acid (p-PhA), 4-hydroxybenzoic acid (4-OHBA), dehydroabietic acid (DA), syringic acid (SA), 3-hydroxybenzoic acid (3-OHBA), isophthalic acid (m-PhA), and vanillic acid (VA).

2-(4-Methylthiazol-5-yl) Ethyl Nitrate Hydrochloride Ameliorates Cognitive Impairment via Modulation of Oxidative Stress and Nuclear Factor Kappa B (NF-κB) Signaling Pathway in Chronic Cerebral Hypoperfusion-Associated Spontaneously Hypertensive Rats.

Hypertension reduces the bioavailability of vascular nitric oxide (NO) and contributes to the onset of vascular dementia (VaD). A loss of NO bioavailability increases inflammation and oxidative stress. 2-(4-Methylthiazol-5-yl) ethyl nitrate hydrochloride (W1302) is a novel nitric oxide donor (NOD) which is undergoing phase I clinical trials in China for the treatment of VaD.

RuPHOX-Ru Catalyzed Asymmetric Cascade Hydrogenation of 3-Substituted Chromones for the Synthesis of Corresponding Chiral Chromanols.

An efficient RuPHOX-Ru catalyzed asymmetric cascade hydrogenation of 3-substituted chromones has been achieved under mild reaction conditions, affording the corresponding chiral 3-substituted chromanols in high yields with excellent enantio- and diastereoselectivities (up to 99 % yield, >99 % ee and >20 : 1 dr). Control reactions and deuterium labelling experiments revealed that a dynamic kinetic resolution process occurs during the subsequent hydrogenation of the C=O double bond, which is responsible for the high performance of the asymmetric cascade hydrogenation. The resulting products allow for several transformations and it was shown that the protocol provides a practical and alternative strategy for the synthesis of chiral 3-substituted chromanols and their derivatives.

Numerical Simulation of Mass Transfer in Hollow Fiber Membrane Module for Membrane-Based Artificial Organs.

The mass transfer behavior in a hollow fiber membrane module of membrane-based artificial organs (such as artificial liver or artificial kidney) were studied by numerical simulation. A new computational fluid dynamics (CFD) method coupled with K-K equation and the tortuous capillary pore diffusion model (TCPDM) was proposed for the simulations. The urea clearance rate predicted by the use of the numerical model agrees well with the experimental data, which verifies the validity of our numerical model.

Discovery of 2-Ethoxy-5-isobutyramido--1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects.

Kv2.1 is involved in regulating neuronal excitability and neuronal cell apoptosis, and inhibiting Kv2.1 is a potential strategy to prevent cell death and achieve neuroprotection in ischemic stroke.

Investigating the pharmacological mechanism of Zhengyuan jiaonang for treating colorectal cancer via network pharmacology analysis and experimental verification.

Ethnopharmacological Relevance: Zhengyuan jiaonang (ZYJN) is a traditional Chinese patent medicine (CPM) used in China for adjuvant cancer therapy, which has been proved to have anti-fatigue effects.

Aim Of Study: The study aims to investigate the antitumor effects of ZYJN and its underlying mechanisms using subcutaneous transplant CT26 model.

Materials And Methods: Fingerprint analysis of ZYJN was performed using high performance liquid chromatography.

The ambient air quality standards, green innovation, and urban air quality: evidence from China.

As China's economy transitions, environmental issues have become a major concern. This study examines the impact of Ambient Air Quality Standards (AAQS) on urban air quality using panel data from 284 cities in China from 2006 to 2019. The study utilizes DID (Difference-in-Difference) models to analyze the regulatory effects of AAQS and its spatial spillover.

Chemical scanning of atomic oxygen at the gas-liquid interface of a NaCl solution via quantum mechanics/molecular mechanics molecular dynamics simulations.

Atmospheric pressure plasmas can serve as double phase reactors to produce plasma activated water for water treatment. However, the physical-chemical processes involving plasma-supplied atomic oxygen and reactive oxygen species in an aqueous solution remain unclear. In this work, quantum mechanics (QM)/molecular mechanics (MM) molecular dynamics simulations (MDs) have been performed to directly observe the chemical reactions occurring between atomic oxygen and a NaCl solution at the gas-liquid interface using a model containing 10,800 atoms.

PHPB Attenuated Cognitive Impairment in Type 2 Diabetic KK-Ay Mice by Modulating SIRT1/Insulin Signaling Pathway and Inhibiting Generation of AGEs.

Diabetes mellitus (DM) has been recognized as an increased risk factor for cognitive impairment, known as diabetic encephalopathy (DE). Hyperglycemia and insulin resistance are the main initiators of DE, which is related to the accumulation of advanced glycation end products (AGEs). Potassium 2-(1-hydroxypentyl)-benzoate (PHPB), a derivative of 3-n-butylphthalide (dl-NBP), has emerged various properties including improved mitochondrial function, antioxidant, anti-neuroinflammation, and neuroprotective effects.

Size distributions of molecular markers for biogenic secondary organic aerosol in urban Beijing.

To understand the source, formation, and seasonality of biogenic secondary organic aerosol (BSOA), a nine-stage cascade impactor was utilized to collect size-segregated particulate samples from April 2017 to January 2018 in Beijing, China. BSOA tracers derived from isoprene, monoterpene, and sesquiterpene were measured with gas chromatography-mass spectrometry. Isoprene and monoterpene SOA tracers exhibited significant seasonal variations, with a summer maximum and a winter minimum.

[A case of tsutsugamushi disease complicated by multiple organ dysfunction syndrome treated by extracorporeal membrane oxygenation].

Tsutsugamushi disease is an acute infectious disease caused by Rickettsia. Occasionally it has been reported in Macau, China. Critical cases are rare.

Carbon-based composites for rechargeable zinc-air batteries: A mini review.

Rechargeable zinc-air batteries (ZABs) have gained a significant amount of attention as next-generation energy conversion and storage devices owing to their high energy density and environmental friendliness, as well as their safety and low cost. The performance of ZABs is dominated by oxygen electrocatalysis, which includes the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER). Therefore, it is crucial to develop effective bifunctional oxygen electrocatalysts that are both highly active and stable.

Application of Multiprocessing Technology of Motion Video Image Based on Sensor Technology in Track and Field Sports.

To improve the accuracy of track and field sports feature recognition, this paper combines sensor technology to improve the motion video image multiprocessing technology and gives the basic principles of image registration. Moreover, this paper chooses a model based on projection transformation. When using a high-speed linear CCD, only the image information on the finish line is collected.

Design and Analysis of a Pneumatic Spring Testing System for Precision Manufacturing.

The vibration isolation effect of the pneumatic spring determines the precision of the manufacturing. In this paper, in order to detect the performance of a pneumatic spring, a multi frequency band testing system with different payload is designed and developed. First, the pneumatic spring structure is analyzed, and the stiffness of the pneumatic spring is obtained based on the ideal gas model, Kelvin-Voigt model, and finite element method.

Research on the Development of Digital Creative Sports Industry Based on Deep Learning.

The core of the digital entrepreneurial sports culture creative industry lies in innovation, which emphasizes the new impetus brought by the digital entrepreneurial sports culture to the social economy. The digital entrepreneurial sports cultural creative industry is rooted in the cultural creative industry. The digital entrepreneurial sports cultural creative industry is also an important part of the sports industry, and its development highly depends on the development of the sports industry.

The Research Progress of Electrical Impedance Tomography for Lung Monitoring.

Medical imaging can intuitively show people the internal structure, morphological information, and organ functions of the organism, which is one of the most important inspection methods in clinical medical diagnosis. Currently used medical imaging methods can only be applied to some diagnostic occasions after qualitative lesions have been generated, and the general imaging technology is usually accompanied by radiation and other conditions. However, electrical impedance tomography has the advantages of being noninvasive and non-radiative.

Effects of light and water disturbance on the growth of Microcystis aeruginosa and the release of algal toxins.

Eutrophication of water constitutes a serious threat to global water quality. Light intensity and water disturbance are important factors affecting the growth of algae and the release of algal toxins. In this study, algal growth indicators, algal enzyme systems, and algal toxin release in Microcystis aeruginosa under different light intensities and water disturbances were determined.

Effects of Activation Conditions on the Properties of Sludge-Based Activated Coke.

Sewage sludge and waste biomass are unavoidable byproducts of municipal and industrial processes. Both materials have significant carbon contents. Activated coke with a developed pore structure can be obtained after its physical activation.

Response of the Bacterial Community and Antibiotic Resistance in Overnight Stagnant Water from a Municipal Pipeline.

Although drinking water safety has raised considerable concern, to date, the hidden health risks in newly released overnight water from a municipal pipeline have seldom received attention. In this study, bacterial community composition and the response of antibiotic-resistant bacteria (ARB) to ciprofloxacin, azithromycin, tetracycline, penicillin, and cephalosporin in overnight stagnant water were analyzed. With increases in heterotrophic bacteria plate count (HPC) during water stagnation, the numbers of ARB and the ARB/HPC ratios for the five antibiotics in resident water were observed to increase, which illustrated that the prevalence of ARB rose in the pipe network water during stagnation time (ST).