Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2 (EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) syndrome comprising cerebellar hypoplasia and motor dysfunction. How EFTUD2 deficiency contributes to these symptoms remains elusive. Here, we demonstrate that specific ablation of Eftud2 in cerebellar Purkinje cells (PCs) in mice results in severe ferroptosis, PC degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with MFDM.

Three-Dimensional Reconstruction and Visualization of Underwater Bridge Piers Using Sonar Imaging.

The quality of underwater bridge piers significantly impacts bridge safety and long-term usability. To address limitations in conventional inspection methods, this paper presents a sonar-based technique for the three-dimensional (3D) reconstruction and visualization of underwater bridge piers. Advanced MS1000 scanning sonar is employed to detect and image bridge piers.

Acute exposure of microwave impairs attention process by activating microglial inflammation.

Background: Attention provides the foundation for cognitions, which was shown to be affected by microwave (MW) radiation. With the ubiquitous of microwaves, public concerns regarding the impact of MW radiation on attention has hence been increased. Our study aims to investigate the potential effect and mechanism of acute microwave exposure on attention.

CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice.

Introduction: The insular cortex is involved in multiple physiological processes including working memory, pain, emotion, and interoceptive functions. Previous studies have indicated that the anterior insular cortex (aIC) also mediates interoceptive attention in humans. However, the exact cellular and physiological function of the aIC in the regulation of this process is still elusive.

Effects of Cavity Thickness and Mold Surface Roughness on the Polymer Flow during Micro Injection Molding.

In micro injection molding, the cavity thickness and surface roughness are the main effects factors of polymer flow in the die designing and affect the quality of molded products significantly. In this study, the effects of cavity thickness and roughness of cavity surface were investigated mainly on polymer flow during molding and on the roughness of molded products. The parts were molded in the cavities with the thickness from 0.

Effects of Cavity Thickness on the Replication of Micro Injection Molded Parts with Microstructure Array.

Parts with microstructure arrays have been widely used in biotechnologies and optical technologies, and their performances are affected by replication uniformity. The uniformity of the microstructure is still a challenge in micro-injection molded parts and is greatly affected by the cavity thickness and process parameters. In this study, the replication uniformity of microstructures is experimentally investigated.

Stress Monitoring of Concrete via Uniaxial Piezoelectric Sensor.

The uniaxial piezoelectric sensor was developed to overcome the problem of reflecting the output charge of the piezoelectric element as a combination of vectors in the three stress directions. The work performance of the uniaxial piezoelectric sensor under varying load patterns and load rates was investigated. The sensor was embedded in concrete to monitor stress, and its elastic modulus was used as the intermediate bridge to establish the correlation between the embedded sensor and the external sensor.

Rolling Bearing Fault Diagnosis Based on Successive Variational Mode Decomposition and the EP Index.

Rolling bearing is an important part guaranteeing the normal operation of rotating machinery, which is also prone to various damages due to severe running conditions. However, it is usually difficult to extract the weak fault characteristic information from rolling bearing vibration signals and to realize a rolling bearing fault diagnosis. Hence, this paper offers a rolling bearing fault diagnosis method based on successive variational mode decomposition (SVMD) and the energy concentration and position accuracy (EP) index.

Gearbox Fault Diagnosis Based on Improved Variational Mode Extraction.

Gearboxes are widely used in drive systems of rotating machinery. The health status of gearboxes considerably influences the normal and reliable operation of rotating machinery. When a gearbox experiences tooth failure, a vibration signal with impulse features is excited.

A Unified High-Order Semianalytical Model and Numerical Simulation for Bistable Polymer Composite Structures.

Bistable polymer composite structures are morphing shells that can change shape and maintain two stable configurations. At present, mainly two types of bistable polymer composite structures are being studied: cross-ply laminates and antisymmetric cylindrical shells. This paper proposes a unified semianalytical model based on the extensible deformation assumption and nonlinear theory of plates and shells to predict bistability.

Stable Characteristics Optimization of Anti-Symmetric Cylindrical Shell with Laminated Carbon Fiber Composite.

This paper proposes a multi-objective optimization model for anti-symmetric cylindrical shell in the bionic gripper structure. Here, the response surface method is used to establish multiple surrogate models of the anti-symmetric cylindrical shell, and the non-dominated sorting genetic algorithm-II (NSGA-II) is used to optimize the design space of the anti-symmetric cylindrical shell; the design points of the anti-symmetric cylindrical shell are verified by experimental methods. The optimization goals are that the first steady state transition load (the transition process of the bionic gripper structure from the open state to the closed state) of the anti-symmetric cylindrical shell is minimized, and the second steady state transition load (the transition process of the bionic gripper structure from the closed state to the open state) is the largest.

Reducing the Burn Marks on Injection-Molded Parts by External Gas-Assisted Injection Molding.

A burn mark is a sort of serious surface defect on injection-molded parts. In some cases, it can be difficult to reduce the burn marks by traditional methods. In this study, external gas-assisted injection molding (EGAIM) was introduced to reduce the burn marks, as EGAIM has been reported to reduce the holding pressure.

Experimental Study on the Axial Compression Performance of an Underwater Concrete Pier Strengthened by Self-Stressed Anti-Washout Concrete and Segments.

Compared with the conventional drainage strengthening techniques, the precast concrete segment assembly strengthening method (PCSAM) is regarded as a fast, more economical, and traffic-friendly underwater strengthening method for damaged bridge piers and piles, as the drainage procedure can be omitted. However, this method still has some disadvantages, such as strength loss of the filling material, debonding of the interface due to shrinkage of the filling material, poor connection effects, and poor durability of the segment sleeves. To solve these problems, the PCSAM is improved in this study by using self-stressed anti-washout concrete (SSAWC) as the filling material and by developing a lining concrete segment sleeve (LCSS) by referring to the design theory for shield lining segments.

Multiscale Modeling and Simulation of Polymer Blends in Injection Molding: A Review.

Modeling and simulation of the morphology evolution of immiscible polymer blends during injection molding is crucial for predicting and tailoring the products' performance. This paper reviews the state-of-the-art progress in the multiscale modeling and simulation of injection molding of polymer blends. Technological development of the injection molding simulation on a macroscale was surveyed in detail.

Pneumatically Controlled Reconfigurable Bistable Bionic Flower for Robotic Gripper.

Beyond their colorful appearances and versatile geometries, flowers can self-shape-morph by adapting to environmental changes. Nature-inspired artificial systems that mimic their natural counterparts in function, flexibility, and adaptation find an emerging application in mobile robotics. In this study, a novel reconfigurable bionic flower made of petal-shaped bistable carbon fiber-reinforced composites and actuated by soft pneumatic actuators is presented.

Warpage Prediction of RHCM Crystalline Parts Based on Multi-Layers.

Warpage is a typical defect for injection-molded parts, especially for crystalline parts molded by rapid heat cycle molding (RHCM). In this paper, a prediction method is proposed for predicting the warpage of crystalline parts molded by the RHCM process. Multi-layer models were established to predict warpage with the same thicknesses as the skin-core structures in the molded parts.

Pneumatically Actuated Soft Gripper with Bistable Structures.

This study presents the design and test of a novel self-adaptive soft gripper, integrating pneumatic actuators and bistable carbon-fiber reinforced polymer laminates. The morphology was designed using the distinct structural characteristics of bistable structures; and the stable gripping configuration of the gripper was maintained through the bistability without continuous pressure application. The sufficient compliance of bistable structures makes the gripper versatile and adaptable to gripping deformable objects.

A Novel Multiscale Methodology for Simulating Droplet Morphology Evolution during Injection Molding of Polymer Blends.

The morphology of polymer blends plays a critical role in determining the properties of the blends and performance of resulting injection-molded parts. However, it is currently impossible to predict the morphology evolution during injection molding and the final micro-structure of the molded parts, as the existing models for the morphology evolution of polymer blends are still limited to a few simple flow fields. To fill this gap, this paper proposed a novel model for droplet morphology evolution during the mold filling process of polymer blends by coupling the models on macro- and meso-scales.

Non-Uniform Curvature Model and Numerical Simulation for Anti-symmetric Cylindrical Bistable Polymer Composite Shells.

The bistability of anti-symmetric thin shallow cylindrical polymer composite shells, made of carbon fiber/epoxy resin, has already been investigated based on the uniform curvature and inextensible deformation assumptions by researchers in detail. In this paper, a non-uniform curvature model that considers the extensible deformations is proposed. Furthermore, a parametric modeling and automatic postprocessing plug-in component for the bistability analysis of polymer composite cylindrical shells is established by means of ABAQUS-software, by which the equilibrium configurations and the load-displacement curves during the snap process can be easily obtained.

Structural Health Monitoring System Based on FBG Sensing Technique for Chinese Ancient Timber Buildings.

Due to the long-term service, Chinese ancient timber buildings show varying degrees of wear. Thus, structural health monitoring (SHM) for these cultural and historical treasures is desperately needed to evaluate the service status. Although there are some FBG sensing-based SHM systems, they are not suitable for Chinese ancient timber buildings due to the differences in architectural types, structural loads, materials, and environment.

The effect of traumatic-like stress exposure on alterations in the temporal social behavior of a rodent population.

Though the relationship between traumatic stress and social behavior, which has been explored for years, is dynamic and largely estimated between dyads, little is known about the causal effects of traumatic stress exposure on the time-dependent dynamic alterations in the social behaviors on a large-group level. We thus investigated the effect of a single prolonged stress (SPS) exposure, a classical animal model that recapitulates posttraumatic stress disorder (PTSD)-like symptoms in rodents, on the spatiotemporal, social behavior changes within a large group of cohabiting rats. One-half of thirty-two Sprague-Dawley rats were assigned to the experimental group and subjected to SPS treatment administered two weeks after baseline social behavior recording; the other half served as the controls.

The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine.

Background: Negative affective states, e.g., anhedonia, may be linked to the long-lasting motivational processes associated with relapse.

A Conflict Model of Reward-seeking Behavior in Male Rats.

The present protocol describes a novel conflict task as a model of inhibitory control in rats. In this model, a natural rewarding stimulus (sexual stimulus) that represents a high-value reward, and the aversive stimuli (pins), are concurrently presented. The male rats have to climb or jump over the obstacle full of pins to approach and investigate the sexual partner.

The Mix Ratio Study of Self-Stressed Anti-Washout Underwater Concrete Used in Nondrainage Strengthening.

Anti-washout underwater concrete (AWC) is widely used in nondrainage strengthening; however, there still exist some problems with it, such as high strength loss and poor interfacial bond in practical engineering application. Based on the study of self-stressed concrete (SSC), a research on the mix ratio for the C30 self-stressed anti-washout underwater concrete (SSAWC) was carried out in this paper in hope of solving the above problems, specifically, by adding an expansive agent to the AWC. The parameters, such as strength, fluidity, anti-dispersity, and expansibility, were picked as target indices in determination of the mix ratio.