Publications by authors named "Shaofei Fu"

Article Synopsis
  • - Dopamine (DA) is an important neurotransmitter in the brain that influences perception, cognition, and hormone secretion, making its monitoring crucial for diagnosing neurological disorders.
  • - The study developed a method that generates fluorescence specifically for DA detection by linking it to an HClO oxidation reaction, allowing for DA visualization in cellular models.
  • - This research is pioneering in using an organic fluorescent molecular probe to detect DA within living cells, enhancing the understanding of DA's role in various health conditions.
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Depression is a serious mental disease that causes grievous harm to human health and quality of life. The vesicular exocytosis of noradrenaline (NE), rather than its intrinsic intracellular concentration, is more associated with depression. Based on the reports on exocytosis of NE, it is reasonable to assume that the viscosity of cells has an important effect on the release of NE.

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Due to the serious harm of depression to human health and quality of life, an accurate diagnosis of depression is warranted. For the complex etiology of depression, a single biomarker diagnostic method often leads to misdiagnosis. As noradrenaline and HClO are closely related to depression, a "dual-locked" fluorescence probe R-NE-HClO for diagnosing of depression through the simultaneous detection of noradrenaline and HClO was designed and synthesized.

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Both imbalance of HS production and the change of viscosity in cells are associated with many diseases such as inflammation, Alzheimer's disease, and Parkinson's disease. Thus, the development of two-channel fluorescent probes for the detection of HS and viscosity is of great significance for the study of pathogenic mechanisms. Herein, we design a two-channel NIR fluorescent probe RHO-DCO-DNP, which was able to selectively respond to HS in one channel (λex = 580 nm, λem = 760 nm) and to viscosity in another channel (λex = 400 nm, λem = 585 nm).

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