A Randomized Controlled Trial of Chuanhutongfeng Mixture for the Treatment of Chronic Gouty Arthritis by Regulating miRNAs.

Background: We investigated whether Chuanhutongfeng mixture has actions on chronic gouty arthritis (CGA) by regulating miRNAs.

Methods: A total of 255 patients with CGA and 30 controls were enrolled. miRNA expression profiles and cluster analysis were preformed; RT-qPCR was used to detect miRNAs associated with CGA.

[Oxidative stress and endothelial dysfunction at different serum uric acid levels].

Objective: To investigate the state of oxidative stress in the subjects with different levels of serum uric acid and to explore the cause of endothelial dysfunction induced by hyperuricemia.

Methods: Male subjects with normal serum uric acid or hyperuricemia were enrolled in this study. According to the levels of serum uric acid, all the participants were divided into five groups.

[An analysis of islet beta-cell function in hyperuricemia].

Objective: To study the islet beta-cell function in patients with simple hyperuricemia (HUA) and to explore the relationship between the level of serum uric acid and insulin resistance.

Methods: The first and second phases of insulin secretion of beta-cell were observed after L-arginine stimulation test and oral glucose tolerance test (OGTT) in 56 hyperuricemic patients and 40 healthy controls.

Results: The peak value of insulin secretion in both groups was at the 2nd min and it began to decrease at the 4th min after L-arginine stimulation.

[Perform analyse on the predictive model of ischemic cardiovascular diseases in Qingdao].

Objective: To explore the clinical usage of the methods and tools of the 10-year's risk estimation of ischemic cardiovascular disease (ICVD) in Chinese.

Methods: The risk of ICVD in 2287 middle-aged Qingdao people was evaluated by the methods and tools of the 10-year's risk estimation of ICVD in Chinese, which was developed by Cardiovascular Institute, Chinese Academy of Medical Sciences.

Results: (1) 98.