Publications by authors named "Shaocheng Zeng"
Article Synopsis
- * Recent studies suggest that MDM2 affects the immune environment around tumors, and its dysregulation may hinder the effectiveness of immunotherapies like PD-1/PD-L1 inhibitors.
- * Combining MDM2 inhibitors with existing immunotherapies shows potential in improving treatment outcomes for tumors that overexpress or amplify MDM2.
Hippo-Yes-associated protein 1 (YAP1) plays an important role in gastric cancer (GC) progression; however, its regulatory network remains unclear. In this study, we identified Copine III (CPNE3) was identified as a novel direct target gene regulated by the YAP1/TEADs transcription factor complex. The downregulation of CPNE3 inhibited proliferation and invasion, and increased the chemosensitivity of GC cells, whereas the overexpression of CPNE3 had the opposite biological effects.
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- Fibroblast growth factors (FGFs) and their receptors (FGFRs) are important for how cells grow and how new blood vessels form. When these systems don't work properly, it can lead to cancer.
- Researchers are exploring the idea of using FGFR inhibitors (which block FGFR) together with immunotherapy (a type of treatment that helps the immune system fight cancer) to make treatments more effective.
- The study looks at how FGFs and FGFRs influence the environment around tumors and how combining FGFR inhibitors with immunotherapy could help patients with certain types of cancer respond better to treatment.
Background: Despite great success, immunotherapy still faces many challenges in practical applications. It was previously found that family with sequence similarity 110 member A (FAM110A) participate in the regulation of the cell cycle and plays an oncogenic role in pancreatic cancer. However, the prognostic value of FAM110A in pan-cancer and its involvement in immune response remain unclear.
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