Publications by authors named "Shaocheng Yang"
Background: Giant (with a diameter of at least 40 mm and a volume of at least 10 cm) pituitary adenomas (GPAs) are intricate tumors that pose considerable difficulty for surgical removal. While endoscopic transsphenoidal surgery (ETS) is a commonly employed technique for these destructive tumors, its effectiveness may be restricted in cases where invasion into multiple compartments is present, leading to limited resection.
Methods: A retrospective review was conducted on the clinical records of 94 patients diagnosed with GPAs who had undergone surgical resection from 2014 to 2022.
Therapeutic Targets of Bufalin on Renal Carcinoma and Mechanisms: Experimental Validation of Network Pharmacology Analysis.
Evid Based Complement Alternat Med
January 2022
Article Synopsis
- The study explored how bufalin affects renal cell carcinoma (RCC) using network pharmacology and experimental methods to identify potential therapeutic targets.
- Research involved analyzing data from PharmMapper and other databases to predict bufalin and RCC-related targets, followed by pathway enrichment analyses with KEGG and GO.
- In vitro experiments confirmed bufalin activates the AKT and MAPK signaling pathways, leading to the identification of 35 intersecting therapeutic targets and various associated biological functions and signaling pathways.
Aims: The basal forebrain (BF) plays an essential role in wakefulness and cognition. Two subtypes of BF gamma-aminobutyric acid (GABA) neurons, including somatostatin-expressing (GABA ) and parvalbumin-positive (GABA ) neurons, function differently in mediating the natural sleep-wake cycle. Since the loss of consciousness induced by general anesthesia and the natural sleep-wake cycle probably share similar mechanisms, it is important to clarify the accurate roles of these neurons in general anesthesia procedure.
View Article and Find Full Text PDFCholinergic neurons in the basal forebrain (BF) have long been considered to be the key neurons in the regulation of cortical and behavioral arousal, and cholinergic activation in the downstream region of the BF can arouse anesthetized rats. However, whether the activation of BF cholinergic neurons can induce behavior and electroencephalogram (EEG) recovery from anesthesia is unclear. In this study, based on a transgenic mouse line expressing ChAT-IRES-Cre, we applied a fiber photometry system combined with GCaMPs expression in the BF and found that both isoflurane and propofol inhibit the activity of BF cholinergic neurons, which is closely related to the consciousness transition.
View Article and Find Full Text PDF